Motif ID: PROX1

Z-value: 0.653


Transcription factors associated with PROX1:

Gene SymbolEntrez IDGene Name
PROX1 ENSG00000117707.11 PROX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PROX1hg19_v2_chr1_+_214163033_2141630730.222.9e-01Click!


Activity profile for motif PROX1.

activity profile for motif PROX1


Sorted Z-values histogram for motif PROX1

Sorted Z-values for motif PROX1



Network of associatons between targets according to the STRING database.



First level regulatory network of PROX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_22918021 3.226 ENST00000288666.5
 RPS4Y2
ribosomal protein S4, Y-linked 2
chr20_-_7921090 1.640 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_35992270 0.861 ENST00000394602.2
ENST00000355574.2
 SLC26A8

solute carrier family 26 (anion exchanger), member 8

chr5_-_156569850 0.835 ENST00000524219.1
 HAVCR2
hepatitis A virus cellular receptor 2
chr17_+_42081914 0.668 ENST00000293404.3
ENST00000589767.1
 NAGS

N-acetylglutamate synthase

chr18_+_2571510 0.581 ENST00000261597.4
ENST00000575515.1
 NDC80

NDC80 kinetochore complex component

chr15_-_91537723 0.538 ENST00000394249.3
ENST00000559811.1
ENST00000442656.2
ENST00000557905.1
ENST00000361919.3
 PRC1




protein regulator of cytokinesis 1




chr10_+_14920843 0.507 ENST00000433779.1
ENST00000378325.3
ENST00000354919.6
ENST00000313519.5
ENST00000420416.1
 SUV39H2




suppressor of variegation 3-9 homolog 2 (Drosophila)




chr10_-_121296045 0.492 ENST00000392865.1
 RGS10
regulator of G-protein signaling 10
chr5_-_157002775 0.480 ENST00000257527.4
 ADAM19
ADAM metallopeptidase domain 19
chr7_+_48128316 0.478 ENST00000341253.4
 UPP1
uridine phosphorylase 1
chr1_-_202311088 0.474 ENST00000367274.4
 UBE2T
ubiquitin-conjugating enzyme E2T (putative)
chr7_+_48128194 0.466 ENST00000416681.1
ENST00000331803.4
ENST00000432131.1
 UPP1


uridine phosphorylase 1


chr2_+_128403439 0.455 ENST00000544369.1
 GPR17
G protein-coupled receptor 17
chr2_+_128403720 0.449 ENST00000272644.3
 GPR17
G protein-coupled receptor 17
chr20_+_30028322 0.423 ENST00000376309.3
 DEFB123
defensin, beta 123
chr2_+_97001491 0.405 ENST00000240423.4
ENST00000427946.1
ENST00000435975.1
ENST00000456906.1
ENST00000455200.1
 NCAPH




non-SMC condensin I complex, subunit H




chr16_+_50300427 0.381 ENST00000394697.2
ENST00000566433.2
ENST00000538642.1
 ADCY7


adenylate cyclase 7


chr9_+_34990219 0.380 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
 DNAJB5


DnaJ (Hsp40) homolog, subfamily B, member 5


chr9_+_132096166 0.376 ENST00000436710.1
 RP11-65J3.1
RP11-65J3.1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.6 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 0.9 GO:0006218 uridine catabolic process(GO:0006218)
0.1 0.9 GO:0019532 oxalate transport(GO:0019532)
0.3 0.8 GO:0002856 natural killer cell tolerance induction(GO:0002519) regulation of tolerance induction dependent upon immune response(GO:0002652) negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.0 0.8 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 0.7 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.6 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.6 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.6 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 0.5 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.1 0.5 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 0.5 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.5 GO:0000022 mitotic spindle elongation(GO:0000022)
0.1 0.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.4 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.2 0.6 GO:0035841 new growing cell tip(GO:0035841)
0.1 0.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942) Ndc80 complex(GO:0031262)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)
0.1 0.4 GO:0000799 nuclear condensin complex(GO:0000799)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0045179 apical cortex(GO:0045179)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.1 GO:0009368 endopeptidase Clp complex(GO:0009368)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0019843 rRNA binding(GO:0019843)
0.5 1.6 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 1.1 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.2 0.9 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.1 0.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.5 GO:1904047 S-adenosyl-L-methionine binding(GO:1904047)
0.0 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.4 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.4 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 0.3 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.3 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0032395 MHC class II receptor activity(GO:0032395)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.9 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism