Motif ID: PRRX1_ALX4_PHOX2A
Z-value: 0.740
Transcription factors associated with PRRX1_ALX4_PHOX2A:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ALX4 | ENSG00000052850.5 | ALX4 |
| PHOX2A | ENSG00000165462.5 | PHOX2A |
| PRRX1 | ENSG00000116132.7 | PRRX1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PHOX2A | hg19_v2_chr11_-_71955210_71955227, hg19_v2_chr11_-_71952236_71952319 | 0.67 | 3.3e-04 | Click! |
| ALX4 | hg19_v2_chr11_-_44331679_44331716 | 0.27 | 2.0e-01 | Click! |
| PRRX1 | hg19_v2_chr1_+_170633047_170633084 | 0.14 | 5.1e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 123 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.1 | 2.2 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.4 | 1.9 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.0 | 1.7 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.1 | 1.6 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.1 | 1.5 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 1.4 | GO:0071498 | cellular response to fluid shear stress(GO:0071498) |
| 0.0 | 1.4 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.0 | 1.4 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 1.3 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.3 | 1.2 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.2 | 1.2 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.4 | 1.1 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 1.1 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.0 | 1.1 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.2 | 1.0 | GO:0036324 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.1 | 1.0 | GO:1900425 | negative regulation of defense response to bacterium(GO:1900425) |
| 0.0 | 1.0 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 0.9 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.3 | 0.8 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 52 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 1.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 1.2 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.1 | 1.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 1.0 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.1 | 1.0 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.1 | 0.9 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.3 | 0.8 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 0.8 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 0.8 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 0.7 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 0.7 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 0.7 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 0.7 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 0.6 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.1 | 0.6 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.6 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 92 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.1 | 2.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.3 | 2.2 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 2.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 2.0 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 1.9 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 1.7 | GO:0005549 | odorant binding(GO:0005549) |
| 0.0 | 1.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.2 | 1.4 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.1 | 1.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 1.2 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 1.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.4 | 1.1 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.0 | 1.1 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.2 | 1.0 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.1 | 1.0 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.0 | 1.0 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.9 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 0.8 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.0 | 0.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 21 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.2 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 1.9 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.2 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.1 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.1 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.1 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.9 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.9 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.8 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.7 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.7 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.6 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.6 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.5 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.4 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.3 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.0 | 0.3 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.2 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 39 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 1.7 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.6 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 1.6 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.4 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 1.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.2 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.0 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.9 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.9 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 0.8 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.8 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.8 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.7 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.6 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.6 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.6 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.6 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.5 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
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