Motif ID: PTF1A

Z-value: 0.609


Transcription factors associated with PTF1A:

Gene SymbolEntrez IDGene Name
PTF1A ENSG00000168267.5 PTF1A



Activity profile for motif PTF1A.

activity profile for motif PTF1A


Sorted Z-values histogram for motif PTF1A

Sorted Z-values for motif PTF1A



Network of associatons between targets according to the STRING database.



First level regulatory network of PTF1A

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_9129598 0.912 ENST00000535586.1
 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr15_-_89764929 0.757 ENST00000268125.5
 RLBP1
retinaldehyde binding protein 1
chr11_-_111794446 0.677 ENST00000527950.1
 CRYAB
crystallin, alpha B
chr19_-_46526304 0.611 ENST00000008938.4
 PGLYRP1
peptidoglycan recognition protein 1
chr12_+_109826524 0.559 ENST00000431443.2
 MYO1H
myosin IH
chr21_+_44073916 0.512 ENST00000349112.3
ENST00000398224.3
 PDE9A

phosphodiesterase 9A

chr8_-_22089845 0.491 ENST00000454243.2
 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr21_+_44073860 0.476 ENST00000335512.4
ENST00000539837.1
ENST00000291539.6
ENST00000380328.2
ENST00000398232.3
ENST00000398234.3
ENST00000398236.3
ENST00000328862.6
ENST00000335440.6
ENST00000398225.3
ENST00000398229.3
ENST00000398227.3
 PDE9A











phosphodiesterase 9A











chr8_-_22089533 0.469 ENST00000321613.3
 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr2_+_120187465 0.460 ENST00000409826.1
ENST00000417645.1
 TMEM37

transmembrane protein 37

chr6_-_46620522 0.436 ENST00000275016.2
 CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr22_-_50050986 0.397 ENST00000405854.1
 C22orf34
chromosome 22 open reading frame 34
chr1_-_45956800 0.395 ENST00000538496.1
 TESK2
testis-specific kinase 2
chr3_-_193272874 0.394 ENST00000342695.4
 ATP13A4
ATPase type 13A4
chr22_-_50051151 0.376 ENST00000400023.1
ENST00000444628.1
 C22orf34

chromosome 22 open reading frame 34

chr20_+_44637526 0.370 ENST00000372330.3
 MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr7_+_150688166 0.355 ENST00000461406.1
 NOS3
nitric oxide synthase 3 (endothelial cell)
chr5_+_140557371 0.341 ENST00000239444.2
 PCDHB8
protocadherin beta 8
chr1_-_204654826 0.325 ENST00000367177.3
 LRRN2
leucine rich repeat neuronal 2
chr4_+_40198527 0.316 ENST00000381799.5
 RHOH
ras homolog family member H

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.2 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.1 1.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.8 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.7 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.2 0.6 GO:0032824 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.0 0.5 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.5 GO:0035988 chondrocyte proliferation(GO:0035988)
0.1 0.4 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740) smooth muscle hyperplasia(GO:0014806)
0.1 0.4 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.4 GO:2001268 positive regulation of keratinocyte migration(GO:0051549) negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0 0.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.3 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.2 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.2 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.2 GO:0030070 insulin processing(GO:0030070)
0.0 0.2 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.7 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.0 GO:0016935 glycine-gated chloride channel complex(GO:0016935)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 1.0 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.8 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 0.6 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.3 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.2 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.1 0.2 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.2 GO:0016499 orexin receptor activity(GO:0016499)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.3 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.4 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels