Motif ID: RAD21_SMC3

Z-value: 1.474

Transcription factors associated with RAD21_SMC3:

Gene SymbolEntrez IDGene Name
RAD21 ENSG00000164754.8 RAD21
SMC3 ENSG00000108055.9 SMC3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMC3hg19_v2_chr10_+_112327425_112327516-0.582.7e-03Click!
RAD21hg19_v2_chr8_-_117886955_1178871050.029.3e-01Click!


Activity profile for motif RAD21_SMC3.

activity profile for motif RAD21_SMC3


Sorted Z-values histogram for motif RAD21_SMC3

Sorted Z-values for motif RAD21_SMC3



Network of associatons between targets according to the STRING database.



First level regulatory network of RAD21_SMC3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_114737472 10.346 ENST00000420161.1
 AC110769.3
AC110769.3
chr15_+_45722727 6.490 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
 C15orf48


chromosome 15 open reading frame 48


chr5_-_136834982 5.815 ENST00000510689.1
ENST00000394945.1
 SPOCK1

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

chr5_+_148521381 5.085 ENST00000504238.1
 ABLIM3
actin binding LIM protein family, member 3
chr5_+_148521046 4.580 ENST00000326685.7
ENST00000356541.3
ENST00000309868.7
 ABLIM3


actin binding LIM protein family, member 3


chr5_+_148521136 4.497 ENST00000506113.1
 ABLIM3
actin binding LIM protein family, member 3
chr19_-_19051927 3.574 ENST00000600077.1
 HOMER3
homer homolog 3 (Drosophila)
chr2_+_114737146 3.493 ENST00000412690.1
 AC010982.1
AC010982.1
chr14_-_75079026 3.452 ENST00000261978.4
 LTBP2
latent transforming growth factor beta binding protein 2
chr5_-_139726181 3.405 ENST00000507104.1
ENST00000230990.6
 HBEGF

heparin-binding EGF-like growth factor

chr7_+_302918 3.282 ENST00000599994.1
 AC187652.1
Protein LOC100996433
chr11_+_118826999 3.229 ENST00000264031.2
 UPK2
uroplakin 2
chr19_-_19051993 3.161 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
 HOMER3



homer homolog 3 (Drosophila)



chr9_-_22009241 3.159 ENST00000380142.4
 CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr18_-_21166841 3.123 ENST00000269228.5
 NPC1
Niemann-Pick disease, type C1
chr9_+_131182697 3.119 ENST00000372838.4
ENST00000411852.1
 CERCAM

cerebral endothelial cell adhesion molecule

chr10_-_76995675 3.067 ENST00000469299.1
 COMTD1
catechol-O-methyltransferase domain containing 1
chr16_+_66638685 3.060 ENST00000565003.1
 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr19_-_55652290 3.047 ENST00000589745.1
 TNNT1
troponin T type 1 (skeletal, slow)
chr10_-_76995769 2.887 ENST00000372538.3
 COMTD1
catechol-O-methyltransferase domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 226 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.7 GO:0030032 lamellipodium assembly(GO:0030032)
1.1 9.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.3 6.8 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 6.5 GO:0010506 regulation of autophagy(GO:0010506)
0.1 5.9 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.6 5.7 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.3 5.7 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.6 4.7 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.4 3.7 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.2 3.7 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 3.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 3.6 GO:0097435 fibril organization(GO:0097435)
0.6 3.5 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 3.3 GO:0001502 cartilage condensation(GO:0001502)
0.8 3.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 3.2 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.4 3.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 3.0 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 2.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.4 2.7 GO:2001137 positive regulation of endocytic recycling(GO:2001137)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 9.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 9.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.1 7.3 GO:0045178 basal part of cell(GO:0045178)
0.2 6.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 6.0 GO:0043025 neuronal cell body(GO:0043025)
0.5 5.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 5.7 GO:0005861 troponin complex(GO:0005861)
0.0 4.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 4.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 4.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.9 GO:0031012 extracellular matrix(GO:0031012)
0.1 3.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.7 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 3.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.6 3.0 GO:0097149 centralspindlin complex(GO:0097149)
0.0 3.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.8 GO:0031674 I band(GO:0031674)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 9.7 GO:0003779 actin binding(GO:0003779)
0.1 9.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 9.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4 6.6 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 6.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 6.0 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 5.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 5.7 GO:0031014 troponin T binding(GO:0031014)
0.5 4.8 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 4.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 4.1 GO:0008201 heparin binding(GO:0008201)
0.1 3.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.8 3.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 3.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.0 3.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 2.9 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.4 2.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 7.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 6.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.9 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 5.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 5.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.6 PID_LKB1_PATHWAY LKB1 signaling events
0.1 4.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.8 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 3.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 2.0 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.4 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.3 PID_NECTIN_PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.4 14.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 4.0 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 3.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 3.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 3.4 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 3.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 3.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 3.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.6 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 1.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.7 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC