Motif ID: RARG

Z-value: 1.450


Transcription factors associated with RARG:

Gene SymbolEntrez IDGene Name
RARG ENSG00000172819.12 RARG

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RARGhg19_v2_chr12_-_53625958_536260360.915.9e-10Click!


Activity profile for motif RARG.

activity profile for motif RARG


Sorted Z-values histogram for motif RARG

Sorted Z-values for motif RARG



Network of associatons between targets according to the STRING database.



First level regulatory network of RARG

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_50340996 6.875 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
 HYAL1





hyaluronoglucosaminidase 1





chr19_-_51472222 6.585 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr19_-_51466681 6.264 ENST00000456750.2
 KLK6
kallikrein-related peptidase 6
chr5_+_33936491 6.130 ENST00000330120.3
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr8_-_23261589 6.000 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
 LOXL2



lysyl oxidase-like 2



chr2_-_31637560 5.832 ENST00000379416.3
 XDH
xanthine dehydrogenase
chr19_-_51472031 5.716 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51487282 5.295 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
 KLK7


kallikrein-related peptidase 7


chr9_+_33795533 5.213 ENST00000379405.3
 PRSS3
protease, serine, 3
chr1_+_150522222 4.912 ENST00000369039.5
 ADAMTSL4
ADAMTS-like 4
chr2_+_234104079 4.888 ENST00000417661.1
 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr17_+_7942424 4.762 ENST00000573359.1
 ALOX15B
arachidonate 15-lipoxygenase, type B
chr19_-_51504852 4.676 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
 KLK8



kallikrein-related peptidase 8



chr8_-_144651024 4.569 ENST00000524906.1
ENST00000532862.1
ENST00000534459.1
 MROH6


maestro heat-like repeat family member 6


chr4_-_111119804 4.542 ENST00000394607.3
ENST00000302274.3
 ELOVL6

ELOVL fatty acid elongase 6

chr2_-_31440377 4.321 ENST00000444918.2
ENST00000403897.3
 CAPN14

calpain 14

chr7_-_107642348 3.808 ENST00000393561.1
 LAMB1
laminin, beta 1
chr5_+_147691979 3.713 ENST00000274565.4
 SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr19_-_51568324 3.657 ENST00000595547.1
ENST00000335422.3
ENST00000595793.1
ENST00000596955.1
 KLK13



kallikrein-related peptidase 13



chr15_-_75017711 3.519 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
 CYP1A1





cytochrome P450, family 1, subfamily A, polypeptide 1






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 585 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 19.2 GO:0016540 protein autoprocessing(GO:0016540)
2.2 8.7 GO:0006218 uridine catabolic process(GO:0006218)
1.4 8.5 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 7.7 GO:0070268 cornification(GO:0070268)
0.7 7.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 7.3 GO:0030574 collagen catabolic process(GO:0030574)
1.0 7.2 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
1.7 6.9 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.2 6.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.5 5.8 GO:0046110 xanthine metabolic process(GO:0046110)
0.6 5.8 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.6 5.8 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.5 5.8 GO:0007144 female meiosis I(GO:0007144)
0.2 5.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.4 5.5 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.2 5.5 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
1.7 5.2 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
1.3 5.2 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 5.0 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
1.6 4.9 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 227 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 9.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 8.7 GO:0030141 secretory granule(GO:0030141)
1.2 8.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 7.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 7.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 7.3 GO:0005604 basement membrane(GO:0005604)
0.1 7.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 6.7 GO:0031965 nuclear membrane(GO:0031965)
0.1 6.3 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 6.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 6.1 GO:0070161 anchoring junction(GO:0070161)
1.0 6.0 GO:0005927 muscle tendon junction(GO:0005927)
0.2 5.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 5.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 5.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 4.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 4.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 4.4 GO:0045095 keratin filament(GO:0045095)
0.0 4.4 GO:0072686 mitotic spindle(GO:0072686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 389 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 42.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 11.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 9.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.7 8.7 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.1 8.5 GO:0005178 integrin binding(GO:0005178)
0.1 8.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
2.0 8.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.7 7.5 GO:0019237 centromeric DNA binding(GO:0019237)
2.4 7.2 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.1 6.8 GO:0008307 structural constituent of muscle(GO:0008307)
1.2 6.1 GO:0004966 galanin receptor activity(GO:0004966)
0.1 6.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.6 5.8 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.6 5.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 5.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
1.1 5.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 5.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 5.5 GO:0004383 guanylate cyclase activity(GO:0004383)
1.7 5.2 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.8 4.9 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 28.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 21.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.2 15.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 9.3 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.2 9.2 NABA_COLLAGENS Genes encoding collagen proteins
0.2 8.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.3 7.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 7.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 6.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 5.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 4.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 4.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 4.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 3.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 3.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.1 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 11.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.6 11.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 10.9 REACTOME_KINESINS Genes involved in Kinesins
0.5 8.3 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 7.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 7.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 6.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 6.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 6.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.1 6.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 5.7 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 5.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.2 4.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 4.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 4.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 3.7 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 3.7 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 3.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA