Motif ID: RCOR1_MTA3

Z-value: 0.900

Transcription factors associated with RCOR1_MTA3:

Gene SymbolEntrez IDGene Name
MTA3 ENSG00000057935.9 MTA3
RCOR1 ENSG00000089902.8 RCOR1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RCOR1hg19_v2_chr14_+_103058948_103059005-0.368.8e-02Click!
MTA3hg19_v2_chr2_+_42795745_42795824,
hg19_v2_chr2_+_42795651_42795676,
hg19_v2_chr2_+_42795839_42795887		-0.116.2e-01Click!


Activity profile for motif RCOR1_MTA3.

activity profile for motif RCOR1_MTA3


Sorted Z-values histogram for motif RCOR1_MTA3

Sorted Z-values for motif RCOR1_MTA3



Network of associatons between targets according to the STRING database.



First level regulatory network of RCOR1_MTA3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_168155730 1.697 ENST00000502330.1
ENST00000357154.3
 SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr6_-_33048483 1.537 ENST00000419277.1
 HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr2_+_102608306 1.513 ENST00000332549.3
 IL1R2
interleukin 1 receptor, type II
chr14_-_21994525 1.507 ENST00000538754.1
 SALL2
spalt-like transcription factor 2
chr7_-_123174610 1.487 ENST00000324698.6
ENST00000434450.1
 IQUB

IQ motif and ubiquitin domain containing

chr19_-_55677999 1.462 ENST00000532817.1
ENST00000527223.2
ENST00000391720.4
 DNAAF3


dynein, axonemal, assembly factor 3


chr4_-_168155700 1.460 ENST00000357545.4
ENST00000512648.1
 SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr5_+_148651409 1.443 ENST00000296721.4
 AFAP1L1
actin filament associated protein 1-like 1
chr5_-_1524015 1.437 ENST00000283415.3
 LPCAT1
lysophosphatidylcholine acyltransferase 1
chr19_+_35630628 1.432 ENST00000588715.1
ENST00000588607.1
 FXYD1

FXYD domain containing ion transport regulator 1

chr19_+_35630926 1.411 ENST00000588081.1
ENST00000589121.1
 FXYD1

FXYD domain containing ion transport regulator 1

chr4_-_168155417 1.367 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
 SPOCK3


sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3


chr7_-_93519471 1.363 ENST00000451238.1
 TFPI2
tissue factor pathway inhibitor 2
chr10_+_35415851 1.351 ENST00000374726.3
 CREM
cAMP responsive element modulator
chr13_+_96204961 1.333 ENST00000299339.2
 CLDN10
claudin 10
chr19_-_55691472 1.333 ENST00000537500.1
 SYT5
synaptotagmin V
chr19_-_55677920 1.308 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
 DNAAF3


dynein, axonemal, assembly factor 3


chr1_+_111889212 1.308 ENST00000369737.4
 PIFO
primary cilia formation
chr3_-_158450475 1.288 ENST00000237696.5
 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr4_-_168155169 1.271 ENST00000534949.1
ENST00000535728.1
 SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,402 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 GO:0060271 cilium morphogenesis(GO:0060271)
0.2 9.5 GO:0042073 intraciliary transport(GO:0042073)
0.3 8.8 GO:0044458 motile cilium assembly(GO:0044458)
0.1 8.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.3 7.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 7.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 6.5 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.2 6.4 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 5.7 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 5.3 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 5.3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 5.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.7 4.4 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.3 4.4 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 3.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 3.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 3.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.3 3.0 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.2 3.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.5 2.9 GO:0030421 defecation(GO:0030421)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 451 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.4 GO:0036064 ciliary basal body(GO:0036064)
0.1 9.2 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.1 8.1 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.4 7.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 6.0 GO:0001650 fibrillar center(GO:0001650)
0.3 5.7 GO:0036038 MKS complex(GO:0036038)
0.1 5.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 5.2 GO:0030496 midbody(GO:0030496)
0.2 5.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 5.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 5.0 GO:0015030 Cajal body(GO:0015030)
0.1 4.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 4.4 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.1 4.1 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 3.9 GO:0005795 Golgi stack(GO:0005795)
0.2 3.5 GO:0001520 outer dense fiber(GO:0001520)
0.2 3.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 3.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.7 3.3 GO:1990769 proximal neuron projection(GO:1990769)
0.0 3.3 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 776 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 7.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 7.7 GO:0043130 ubiquitin binding(GO:0043130)
0.3 7.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 6.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 5.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.3 4.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 4.4 GO:0031005 filamin binding(GO:0031005)
0.3 4.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 4.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 4.1 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.1 3.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 3.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 3.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 3.7 GO:0042393 histone binding(GO:0042393)
0.2 3.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 3.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.3 3.4 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.1 3.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 3.0 GO:0019206 nucleoside kinase activity(GO:0019206)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.2 PID_PLK1_PATHWAY PLK1 signaling events
0.1 7.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 6.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 6.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 6.1 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 5.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 5.1 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 4.4 PID_MYC_PATHWAY C-MYC pathway
0.0 4.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 4.1 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 3.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 3.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 2.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 7.8 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.3 7.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 7.4 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 6.4 REACTOME_KINESINS Genes involved in Kinesins
0.2 5.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 5.3 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 5.2 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.2 5.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 4.8 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 4.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 4.8 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 4.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 4.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 3.9 REACTOME_GLOBAL_GENOMIC_NER_GG_NER Genes involved in Global Genomic NER (GG-NER)
0.1 3.9 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 3.9 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.1 3.4 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 3.3 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 3.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling