Motif ID: REL

Z-value: 1.179


Transcription factors associated with REL:

Gene SymbolEntrez IDGene Name
REL ENSG00000162924.9 REL

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RELhg19_v2_chr2_+_61108650_611086870.396.0e-02Click!


Activity profile for motif REL.

activity profile for motif REL


Sorted Z-values histogram for motif REL

Sorted Z-values for motif REL



Network of associatons between targets according to the STRING database.



First level regulatory network of REL

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51471381 4.837 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51471362 4.701 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr2_-_113594279 3.310 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr2_+_228678550 3.236 ENST00000409189.3
ENST00000358813.4
 CCL20

chemokine (C-C motif) ligand 20

chr19_-_51472031 3.048 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr18_+_21452964 2.954 ENST00000587184.1
 LAMA3
laminin, alpha 3
chr7_+_107301065 2.890 ENST00000265715.3
 SLC26A4
solute carrier family 26 (anion exchanger), member 4
chr18_+_21529811 2.753 ENST00000588004.1
 LAMA3
laminin, alpha 3
chr4_-_74864386 2.582 ENST00000296027.4
 CXCL5
chemokine (C-X-C motif) ligand 5
chr12_-_95009837 2.345 ENST00000551457.1
 TMCC3
transmembrane and coiled-coil domain family 3
chr18_+_21452804 2.319 ENST00000269217.6
 LAMA3
laminin, alpha 3
chr11_-_58345569 2.283 ENST00000528954.1
ENST00000528489.1
 LPXN

leupaxin

chr9_-_136344197 2.217 ENST00000414172.1
ENST00000371897.4
 SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chrX_-_153599578 2.142 ENST00000360319.4
ENST00000344736.4
 FLNA

filamin A, alpha

chr12_-_76425368 2.052 ENST00000602540.1
 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr2_+_102314161 2.023 ENST00000425019.1
 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr19_+_41725088 1.951 ENST00000301178.4
 AXL
AXL receptor tyrosine kinase
chr18_+_33877654 1.861 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
 FHOD3



formin homology 2 domain containing 3



chr12_+_53491220 1.822 ENST00000548547.1
ENST00000301464.3
 IGFBP6

insulin-like growth factor binding protein 6

chr19_-_50143452 1.795 ENST00000246792.3
 RRAS
related RAS viral (r-ras) oncogene homolog

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.1 GO:0016540 protein autoprocessing(GO:0016540)
0.3 8.7 GO:0031581 hemidesmosome assembly(GO:0031581)
1.1 3.3 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
1.1 3.2 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 3.1 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.3 2.9 GO:0015705 iodide transport(GO:0015705)
0.1 2.9 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.3 2.6 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.2 2.6 GO:0051639 actin filament network formation(GO:0051639)
0.7 2.2 GO:0045210 FasL biosynthetic process(GO:0045210)
0.1 2.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 2.2 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.5 2.1 GO:0044805 late nucleophagy(GO:0044805)
0.4 2.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.3 2.1 GO:2000669 positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669)
0.0 2.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.4 1.8 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.2 1.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2 1.8 GO:1903243 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.0 1.8 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.4 GO:0030141 secretory granule(GO:0030141)
1.1 8.7 GO:0005610 laminin-5 complex(GO:0005610)
0.1 3.4 GO:0002102 podosome(GO:0002102)
0.0 3.4 GO:0031526 brush border membrane(GO:0031526)
0.2 3.1 GO:0008091 spectrin(GO:0008091)
0.0 2.3 GO:0000421 autophagosome membrane(GO:0000421)
0.7 2.1 GO:0031523 Myb complex(GO:0031523)
0.1 2.1 GO:0033643 host cell part(GO:0033643)
0.0 1.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.4 1.8 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.2 1.8 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 1.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.4 GO:0000145 exocyst(GO:0000145)
0.1 1.3 GO:0031209 SCAR complex(GO:0031209)
0.3 1.2 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 1.1 GO:0005685 U1 snRNP(GO:0005685)
0.0 1.0 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 1.0 GO:0001533 cornified envelope(GO:0001533)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 0.8 GO:1990682 CSF1-CSF1R complex(GO:1990682)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
1.1 3.2 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.3 3.1 GO:0042731 PH domain binding(GO:0042731)
0.6 3.0 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.6 2.9 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 2.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.5 2.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 2.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 2.0 GO:0004111 creatine kinase activity(GO:0004111)
0.2 1.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.8 GO:0019003 GDP binding(GO:0019003)
0.1 1.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 1.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.5 GO:0048185 activin binding(GO:0048185)
0.1 1.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.4 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 1.2 GO:0017049 GTP-Rho binding(GO:0017049)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.4 8.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 7.3 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 5.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.8 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 3.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.3 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 2.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.2 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.1 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 0.7 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID_ATF2_PATHWAY ATF-2 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.9 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 4.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.9 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 3.9 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 3.8 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 3.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 2.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 2.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.2 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.0 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.9 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.8 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling