Motif ID: REST

Z-value: 0.989


Transcription factors associated with REST:

Gene SymbolEntrez IDGene Name
REST ENSG00000084093.11 REST

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.086.9e-01Click!


Activity profile for motif REST.

activity profile for motif REST


Sorted Z-values histogram for motif REST

Sorted Z-values for motif REST



Network of associatons between targets according to the STRING database.



First level regulatory network of REST

PNG image of the network

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Top targets:


Showing 1 to 20 of 125 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_33936491 4.083 ENST00000330120.3
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr19_-_51845378 2.066 ENST00000335624.4
 VSIG10L
V-set and immunoglobulin domain containing 10 like
chr8_-_91095099 1.811 ENST00000265431.3
 CALB1
calbindin 1, 28kDa
chr20_+_62327996 1.765 ENST00000369996.1
 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr4_+_8582287 1.488 ENST00000382487.4
 GPR78
G protein-coupled receptor 78
chr12_+_71833756 1.376 ENST00000536515.1
ENST00000540815.2
 LGR5

leucine-rich repeat containing G protein-coupled receptor 5

chr9_+_135457530 1.310 ENST00000263610.2
 BARHL1
BarH-like homeobox 1
chr10_+_99609996 1.286 ENST00000370602.1
 GOLGA7B
golgin A7 family, member B
chr6_+_35773070 1.193 ENST00000373853.1
ENST00000360215.1
 LHFPL5

lipoma HMGIC fusion partner-like 5

chr10_-_79398250 0.939 ENST00000286627.5
 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr7_+_154862028 0.905 ENST00000287907.2
 HTR5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
chr17_+_30813576 0.839 ENST00000313401.3
 CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr2_+_115199876 0.795 ENST00000436732.1
ENST00000410059.1
 DPP10

dipeptidyl-peptidase 10 (non-functional)

chr12_-_29936731 0.784 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
 TMTC1


transmembrane and tetratricopeptide repeat containing 1


chr5_-_151304337 0.771 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
 GLRA1


glycine receptor, alpha 1


chr20_+_30555805 0.763 ENST00000562532.2
 XKR7
XK, Kell blood group complex subunit-related family, member 7
chr3_-_42743006 0.725 ENST00000310417.5
 HHATL
hedgehog acyltransferase-like
chr14_+_93389425 0.721 ENST00000216492.5
ENST00000334654.4
 CHGA

chromogranin A (parathyroid secretory protein 1)

chr15_-_72612470 0.712 ENST00000287202.5
 CELF6
CUGBP, Elav-like family member 6
chr3_+_9745510 0.703 ENST00000383831.3
 CPNE9
copine family member IX

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 1.8 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 1.8 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 1.6 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 1.5 GO:0060088 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) auditory receptor cell stereocilium organization(GO:0060088)
0.0 1.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.4 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 1.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3 1.1 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 1.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 1.1 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.1 1.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 1.0 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 0.9 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.3 0.8 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.8 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.8 GO:0008218 bioluminescence(GO:0008218)
0.0 0.8 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.8 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0043195 terminal bouton(GO:0043195)
0.0 1.9 GO:0005901 caveola(GO:0005901)
0.3 1.5 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 1.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.2 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 0.8 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.7 GO:0033010 paranodal junction(GO:0033010)
0.0 0.7 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.4 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.1 0.3 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.3 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.1 GO:0004966 galanin receptor activity(GO:0004966)
0.4 1.8 GO:0005499 vitamin D binding(GO:0005499)
0.0 1.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 1.6 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 1.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 1.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 1.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.0 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 1.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.9 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.3 0.8 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.2 0.6 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.1 0.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.6 GO:0008430 selenium binding(GO:0008430)
0.0 0.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.2 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 0.9 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling