Motif ID: RFX3_RFX2
Z-value: 16.260
Transcription factors associated with RFX3_RFX2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| RFX2 | ENSG00000087903.8 | RFX2 |
| RFX3 | ENSG00000080298.11 | RFX3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX2 | hg19_v2_chr19_-_6110474_6110551 | 0.99 | 3.9e-19 | Click! |
| RFX3 | hg19_v2_chr9_-_3525968_3526016 | 0.98 | 3.6e-16 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 34.4 | 103.2 | GO:0002514 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) |
| 22.5 | 90.1 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 21.8 | 239.9 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 21.1 | 675.2 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 15.4 | 92.4 | GO:0010734 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 15.2 | 743.2 | GO:0035082 | axoneme assembly(GO:0035082) |
| 11.4 | 34.3 | GO:0050902 | leukocyte adhesive activation(GO:0050902) |
| 10.3 | 30.8 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 8.8 | 193.5 | GO:0003341 | cilium movement(GO:0003341) |
| 8.6 | 77.4 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 6.5 | 19.5 | GO:0006174 | dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571) |
| 6.1 | 24.3 | GO:1901895 | negative regulation of calcium-transporting ATPase activity(GO:1901895) |
| 6.0 | 102.5 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 5.8 | 291.7 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 5.4 | 43.2 | GO:1903751 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 5.3 | 21.3 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 4.9 | 44.5 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 4.9 | 29.1 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 4.8 | 14.3 | GO:0060279 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 4.1 | 45.4 | GO:0042073 | intraciliary transport(GO:0042073) |
| 4.1 | 78.0 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 4.0 | 47.7 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 3.8 | 22.7 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 3.6 | 135.4 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 3.1 | 27.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 3.0 | 47.3 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 2.9 | 23.4 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 2.9 | 34.8 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 2.8 | 17.0 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 2.8 | 16.9 | GO:0001757 | somite specification(GO:0001757) |
| 2.8 | 86.7 | GO:0002021 | response to dietary excess(GO:0002021) |
| 2.6 | 122.1 | GO:0048741 | skeletal muscle fiber development(GO:0048741) |
| 2.6 | 15.6 | GO:0031392 | regulation of prostaglandin biosynthetic process(GO:0031392) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) |
| 2.6 | 113.1 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 2.4 | 19.6 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 2.4 | 29.3 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 2.4 | 17.1 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 2.4 | 9.7 | GO:0070426 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 2.4 | 4.8 | GO:0098917 | retrograde trans-synaptic signaling(GO:0098917) |
| 2.4 | 16.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 2.3 | 246.1 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 2.3 | 6.8 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
| 2.2 | 8.9 | GO:1902361 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 2.2 | 17.4 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 2.2 | 19.4 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 2.1 | 29.9 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 2.1 | 12.5 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion(GO:1903748) |
| 2.0 | 8.1 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 2.0 | 8.1 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 2.0 | 8.0 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 2.0 | 55.5 | GO:0034389 | lipid particle organization(GO:0034389) |
| 1.9 | 58.9 | GO:0007141 | male meiosis I(GO:0007141) |
| 1.9 | 7.5 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
| 1.8 | 25.1 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 1.7 | 27.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 1.7 | 33.5 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 1.7 | 8.4 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 1.6 | 3.3 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 1.6 | 35.4 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 1.6 | 22.3 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 1.5 | 4.6 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 1.5 | 104.9 | GO:0021795 | cerebral cortex cell migration(GO:0021795) |
| 1.5 | 14.8 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 1.5 | 5.9 | GO:1902613 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 1.5 | 33.5 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 1.4 | 26.9 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 1.4 | 4.1 | GO:0090071 | negative regulation of ribosome biogenesis(GO:0090071) |
| 1.3 | 16.9 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 1.3 | 159.5 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 1.2 | 278.9 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 1.1 | 22.3 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 1.1 | 3.3 | GO:0035552 | oxidative single-stranded DNA demethylation(GO:0035552) |
| 1.1 | 60.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 1.0 | 27.6 | GO:0021591 | ventricular system development(GO:0021591) |
| 0.9 | 8.2 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.9 | 25.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.9 | 87.9 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.9 | 8.5 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.8 | 7.9 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.8 | 32.0 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
| 0.8 | 17.0 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.8 | 24.5 | GO:0043949 | regulation of cAMP-mediated signaling(GO:0043949) |
| 0.8 | 7.6 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.8 | 3.0 | GO:0060849 | radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.7 | 2.2 | GO:0072334 | UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334) |
| 0.7 | 2.9 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.7 | 35.7 | GO:0007405 | neuroblast proliferation(GO:0007405) |
| 0.7 | 3.6 | GO:1904764 | regulation of fibril organization(GO:1902903) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 0.7 | 0.7 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
| 0.7 | 27.3 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.7 | 0.7 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
| 0.7 | 4.6 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.6 | 20.6 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.6 | 1.9 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 0.6 | 12.1 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.6 | 6.0 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.6 | 85.5 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.6 | 17.6 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.6 | 7.0 | GO:0015886 | heme transport(GO:0015886) |
| 0.6 | 5.2 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.6 | 2.9 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.6 | 27.0 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.6 | 7.3 | GO:0001302 | replicative cell aging(GO:0001302) |
| 0.5 | 2.2 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.5 | 71.2 | GO:0007286 | spermatid development(GO:0007286) |
| 0.5 | 6.5 | GO:0010838 | positive regulation of keratinocyte proliferation(GO:0010838) |
| 0.5 | 5.7 | GO:0032782 | bile acid secretion(GO:0032782) |
| 0.5 | 13.8 | GO:0001975 | response to amphetamine(GO:0001975) |
| 0.5 | 7.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.5 | 13.8 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.5 | 33.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.5 | 15.2 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.5 | 6.1 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.5 | 11.3 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.4 | 35.4 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.4 | 13.7 | GO:0002437 | inflammatory response to antigenic stimulus(GO:0002437) |
| 0.4 | 53.5 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.4 | 6.9 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.4 | 20.4 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.4 | 5.3 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.4 | 8.6 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.3 | 6.4 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.3 | 41.3 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.3 | 3.2 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.3 | 35.2 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.3 | 3.9 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.3 | 2.1 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.3 | 2.9 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
| 0.3 | 7.3 | GO:0035357 | peroxisome proliferator activated receptor signaling pathway(GO:0035357) |
| 0.3 | 5.2 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.3 | 16.5 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.3 | 1.6 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.3 | 5.2 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.3 | 9.4 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.3 | 1.5 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.3 | 4.8 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.2 | 2.5 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.2 | 9.7 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.2 | 7.2 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.2 | 6.1 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.2 | 1.4 | GO:0033183 | negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) |
| 0.2 | 5.4 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.2 | 70.0 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.2 | 3.5 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
| 0.2 | 8.5 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.2 | 1.9 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.2 | 2.9 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.2 | 3.2 | GO:0006004 | fucose metabolic process(GO:0006004) |
| 0.1 | 64.7 | GO:0007283 | spermatogenesis(GO:0007283) |
| 0.1 | 8.2 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 2.5 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.1 | 0.5 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 0.1 | 3.3 | GO:0048147 | negative regulation of fibroblast proliferation(GO:0048147) |
| 0.1 | 3.6 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 1.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.1 | 4.2 | GO:0008038 | neuron recognition(GO:0008038) |
| 0.1 | 2.4 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 2.8 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 8.0 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.1 | 2.0 | GO:0071028 | nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028) |
| 0.1 | 0.7 | GO:0006361 | transcription from RNA polymerase I promoter(GO:0006360) transcription initiation from RNA polymerase I promoter(GO:0006361) transcription elongation from RNA polymerase I promoter(GO:0006362) termination of RNA polymerase I transcription(GO:0006363) |
| 0.1 | 0.4 | GO:0036491 | regulation of translation in response to endoplasmic reticulum stress(GO:0036490) regulation of translation initiation in response to endoplasmic reticulum stress(GO:0036491) eiF2alpha phosphorylation in response to endoplasmic reticulum stress(GO:0036492) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 0.1 | 52.5 | GO:0031344 | regulation of cell projection organization(GO:0031344) |
| 0.1 | 17.6 | GO:0045444 | fat cell differentiation(GO:0045444) |
| 0.1 | 10.8 | GO:1901796 | regulation of signal transduction by p53 class mediator(GO:1901796) |
| 0.1 | 0.6 | GO:0046325 | negative regulation of glucose import(GO:0046325) |
| 0.1 | 0.9 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.1 | 12.2 | GO:0008285 | negative regulation of cell proliferation(GO:0008285) |
| 0.1 | 2.0 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
| 0.1 | 2.3 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.1 | 2.2 | GO:0042407 | inner mitochondrial membrane organization(GO:0007007) cristae formation(GO:0042407) |
| 0.1 | 1.7 | GO:0035902 | response to immobilization stress(GO:0035902) |
| 0.1 | 0.6 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.1 | 2.6 | GO:0016925 | protein sumoylation(GO:0016925) |
| 0.1 | 4.1 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.1 | 0.3 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.0 | 1.3 | GO:0034067 | protein localization to Golgi apparatus(GO:0034067) |
| 0.0 | 0.5 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.0 | 1.3 | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) |
| 0.0 | 1.1 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 0.1 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.0 | 1.1 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.0 | 1.0 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.0 | 0.3 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 1.3 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.0 | 1.1 | GO:0035773 | insulin secretion involved in cellular response to glucose stimulus(GO:0035773) |
| 0.0 | 1.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.6 | GO:0045454 | cell redox homeostasis(GO:0045454) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 46.0 | 137.9 | GO:0001534 | radial spoke(GO:0001534) |
| 43.3 | 303.4 | GO:0002177 | manchette(GO:0002177) |
| 34.6 | 414.8 | GO:0072687 | meiotic spindle(GO:0072687) |
| 24.8 | 123.8 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 23.1 | 92.5 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 18.8 | 56.3 | GO:1990716 | axonemal central apparatus(GO:1990716) |
| 11.8 | 58.9 | GO:0097123 | cyclin A1-CDK2 complex(GO:0097123) |
| 11.2 | 112.3 | GO:0097427 | microtubule bundle(GO:0097427) |
| 10.9 | 314.9 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 10.0 | 39.8 | GO:0016939 | kinesin II complex(GO:0016939) |
| 9.6 | 182.8 | GO:0036038 | MKS complex(GO:0036038) |
| 8.9 | 44.5 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 8.1 | 24.2 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 7.7 | 84.9 | GO:0034464 | BBSome(GO:0034464) |
| 7.1 | 792.7 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 6.6 | 192.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 5.9 | 17.6 | GO:0043291 | RAVE complex(GO:0043291) |
| 4.4 | 21.8 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 4.1 | 95.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 3.4 | 30.6 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 3.1 | 166.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 3.1 | 36.8 | GO:0001520 | outer dense fiber(GO:0001520) |
| 2.8 | 39.3 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 2.4 | 2.4 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 2.2 | 188.6 | GO:0036126 | sperm flagellum(GO:0036126) |
| 2.2 | 134.7 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 2.1 | 21.3 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 2.1 | 16.9 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 2.0 | 18.3 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 1.9 | 135.4 | GO:0002102 | podosome(GO:0002102) |
| 1.8 | 15.9 | GO:0097542 | ciliary tip(GO:0097542) |
| 1.6 | 128.2 | GO:0036064 | ciliary basal body(GO:0036064) |
| 1.5 | 10.8 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 1.5 | 7.5 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 1.4 | 40.2 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 1.3 | 8.8 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 1.1 | 89.4 | GO:0005814 | centriole(GO:0005814) |
| 1.1 | 20.5 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 1.1 | 362.0 | GO:0005929 | cilium(GO:0005929) |
| 1.0 | 8.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 1.0 | 15.2 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.9 | 17.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.9 | 19.3 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.9 | 68.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.9 | 13.2 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.8 | 10.8 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.8 | 5.3 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.7 | 74.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.6 | 51.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.6 | 1.3 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 0.6 | 6.0 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.6 | 4.8 | GO:0043196 | varicosity(GO:0043196) |
| 0.6 | 17.1 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.5 | 239.8 | GO:0005874 | microtubule(GO:0005874) |
| 0.5 | 8.0 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.5 | 90.9 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.5 | 5.2 | GO:0005655 | nucleolar ribonuclease P complex(GO:0005655) |
| 0.5 | 5.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.5 | 3.6 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.5 | 21.5 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.5 | 3.3 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.4 | 21.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.4 | 1.6 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.4 | 58.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.4 | 6.8 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.4 | 1.9 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.4 | 56.2 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.4 | 24.0 | GO:0005901 | caveola(GO:0005901) |
| 0.3 | 109.0 | GO:0005813 | centrosome(GO:0005813) |
| 0.3 | 4.1 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.3 | 5.7 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.3 | 29.5 | GO:1902911 | protein kinase complex(GO:1902911) |
| 0.3 | 16.1 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.3 | 5.1 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.2 | 8.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 170.4 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.2 | 2.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.2 | 23.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 0.7 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.1 | 1.7 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.1 | 2.9 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 2.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 8.2 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 8.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 1.3 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.1 | 6.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 5.1 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 1.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 12.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 0.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 38.2 | GO:0044431 | Golgi apparatus part(GO:0044431) |
| 0.0 | 3.4 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 2.4 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.9 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 1.9 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.8 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 0.5 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.0 | 0.8 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 37.9 | 37.9 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 12.8 | 38.4 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 12.6 | 278.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 12.2 | 12.2 | GO:0005119 | smoothened binding(GO:0005119) |
| 8.3 | 33.2 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 7.1 | 92.5 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 5.6 | 50.2 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 5.2 | 15.6 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 5.2 | 31.0 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 4.9 | 136.8 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 4.8 | 28.5 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 4.4 | 178.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 3.9 | 27.6 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
| 3.7 | 14.8 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 3.5 | 28.2 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 3.4 | 94.0 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 3.1 | 43.2 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 3.0 | 78.0 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 2.8 | 28.1 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 2.8 | 16.8 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 2.8 | 13.8 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 2.7 | 34.8 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 2.5 | 12.6 | GO:1990189 | peptide-serine-N-acetyltransferase activity(GO:1990189) |
| 2.5 | 12.5 | GO:0002046 | opsin binding(GO:0002046) |
| 2.5 | 32.5 | GO:0034452 | dynactin binding(GO:0034452) |
| 2.5 | 57.3 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 2.5 | 22.3 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 2.4 | 16.9 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 2.3 | 25.8 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 2.3 | 6.9 | GO:0003943 | N-acetylgalactosamine-4-sulfatase activity(GO:0003943) |
| 2.3 | 6.8 | GO:0047322 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405) |
| 2.1 | 10.3 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 1.8 | 50.7 | GO:0070840 | dynein complex binding(GO:0070840) |
| 1.7 | 136.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 1.7 | 31.0 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 1.6 | 93.8 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 1.5 | 5.9 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 1.5 | 26.5 | GO:0070513 | death domain binding(GO:0070513) |
| 1.4 | 24.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 1.3 | 344.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 1.3 | 11.4 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 1.3 | 7.5 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
| 1.2 | 8.5 | GO:0004673 | phosphorelay sensor kinase activity(GO:0000155) protein histidine kinase activity(GO:0004673) |
| 1.2 | 62.4 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 1.2 | 33.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 1.1 | 30.4 | GO:0005112 | Notch binding(GO:0005112) |
| 1.1 | 8.9 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.1 | 3.3 | GO:0035514 | DNA demethylase activity(GO:0035514) |
| 1.1 | 60.6 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 1.0 | 39.5 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.9 | 40.2 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.9 | 14.9 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.8 | 25.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.8 | 2.5 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.8 | 29.9 | GO:0001637 | G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950) |
| 0.8 | 34.3 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.8 | 2.3 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.7 | 2.2 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.7 | 28.3 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.7 | 47.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.7 | 77.3 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.7 | 3.6 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.7 | 19.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.7 | 2.0 | GO:0034353 | RNA pyrophosphohydrolase activity(GO:0034353) |
| 0.6 | 7.0 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.6 | 29.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.6 | 4.7 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.6 | 75.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.6 | 6.1 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.5 | 9.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.5 | 13.3 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.5 | 5.4 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.5 | 15.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.5 | 18.3 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.5 | 2.3 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.5 | 4.6 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.4 | 8.1 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.4 | 31.6 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.4 | 408.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.4 | 8.2 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.3 | 30.0 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 0.3 | 4.1 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.3 | 1.4 | GO:0032408 | MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408) |
| 0.3 | 5.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.3 | 2.5 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.3 | 0.6 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 0.3 | 3.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.3 | 2.9 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.3 | 134.6 | GO:0005525 | GTP binding(GO:0005525) |
| 0.3 | 4.3 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.3 | 4.8 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.3 | 1.6 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.3 | 27.2 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.3 | 6.0 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.2 | 1.9 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.2 | 14.6 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.2 | 9.5 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.2 | 7.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.2 | 1.0 | GO:0016417 | S-acyltransferase activity(GO:0016417) |
| 0.2 | 114.0 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.2 | 5.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 6.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 12.2 | GO:0016279 | protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.1 | 31.2 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 60.4 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.1 | 14.3 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 19.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 66.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 22.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.1 | 38.3 | GO:0004857 | enzyme inhibitor activity(GO:0004857) |
| 0.1 | 2.3 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 12.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 3.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 5.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 1.5 | GO:0003774 | motor activity(GO:0003774) |
| 0.1 | 2.2 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 7.1 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 0.5 | GO:0015526 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.1 | 1.0 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 1.0 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.1 | 0.6 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.0 | 766.8 | GO:0003674 | molecular_function(GO:0003674) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 51.0 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.6 | 29.5 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.6 | 24.9 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.5 | 35.9 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.5 | 39.1 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.4 | 43.3 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.4 | 19.4 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.3 | 5.9 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.3 | 24.0 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.3 | 17.8 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.2 | 10.8 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.2 | 16.3 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.2 | 6.1 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 30.7 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.1 | 4.7 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.1 | 2.0 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 3.5 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 8.1 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 7.3 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 7.1 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.1 | 2.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 4.4 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 1.3 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.1 | 16.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.1 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 2.2 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 4.1 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 3.6 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.9 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.2 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.6 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.7 | PID_BMP_PATHWAY | BMP receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 58.9 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.8 | 66.6 | REACTOME_KINESINS | Genes involved in Kinesins |
| 1.6 | 29.6 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 1.5 | 29.9 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 1.2 | 24.9 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 1.1 | 29.1 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 1.0 | 17.4 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.0 | 14.3 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.7 | 7.6 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.6 | 34.8 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.6 | 15.9 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.5 | 34.3 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.4 | 39.4 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.4 | 6.0 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.3 | 8.6 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.3 | 9.5 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.3 | 6.8 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.2 | 8.1 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 8.5 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 1.6 | REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY | Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| 0.2 | 3.4 | REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.2 | 5.2 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 6.7 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 14.0 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 6.1 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 6.1 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 5.7 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 8.2 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.2 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 5.1 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 0.7 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 2.9 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 2.8 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.3 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 1.2 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.5 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.0 | 3.6 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 7.9 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 5.7 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.6 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.3 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 1.8 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 4.6 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 1.2 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 2.7 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.4 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
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