Motif ID: RFX3_RFX2

Z-value: 16.260

Transcription factors associated with RFX3_RFX2:

Gene SymbolEntrez IDGene Name
RFX2 ENSG00000087903.8 RFX2
RFX3 ENSG00000080298.11 RFX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RFX2hg19_v2_chr19_-_6110474_61105510.993.9e-19Click!
RFX3hg19_v2_chr9_-_3525968_35260160.983.6e-16Click!


Activity profile for motif RFX3_RFX2.

activity profile for motif RFX3_RFX2


Sorted Z-values histogram for motif RFX3_RFX2

Sorted Z-values for motif RFX3_RFX2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX3_RFX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_-_43916433 212.143 ENST00000291536.3
 RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr21_-_43916296 202.607 ENST00000398352.3
 RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr1_-_109656439 176.549 ENST00000369949.4
 C1orf194
chromosome 1 open reading frame 194
chr1_-_159869912 132.240 ENST00000368099.4
 CCDC19
coiled-coil domain containing 19
chr16_-_67427389 120.512 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
 TPPP3


tubulin polymerization-promoting protein family member 3


chr1_+_151682909 119.642 ENST00000326413.3
ENST00000442233.2
 RIIAD1
AL589765.1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
Uncharacterized protein; cDNA FLJ36032 fis, clone TESTI2017069
chr22_+_23487513 111.673 ENST00000263116.2
ENST00000341989.4
 RAB36

RAB36, member RAS oncogene family

chr17_-_6735035 107.897 ENST00000338694.2
 TEKT1
tektin 1
chr17_-_6735012 107.533 ENST00000535086.1
 TEKT1
tektin 1
chr15_+_71184931 105.183 ENST00000560369.1
ENST00000260382.5
 LRRC49

leucine rich repeat containing 49

chr15_+_71185148 104.958 ENST00000443425.2
ENST00000560755.1
 LRRC49

leucine rich repeat containing 49

chr2_+_228736321 104.810 ENST00000309931.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr17_-_74137374 103.205 ENST00000322957.6
 FOXJ1
forkhead box J1
chr1_+_38022572 99.713 ENST00000541606.1
 DNALI1
dynein, axonemal, light intermediate chain 1
chr6_+_43612750 98.256 ENST00000372165.4
ENST00000372163.4
 RSPH9

radial spoke head 9 homolog (Chlamydomonas)

chr3_-_197676740 94.286 ENST00000452735.1
ENST00000453254.1
ENST00000455191.1
 IQCG


IQ motif containing G


chr1_-_169396666 92.948 ENST00000456107.1
ENST00000367805.3
 CCDC181

coiled-coil domain containing 181

chr2_+_228736335 92.752 ENST00000440997.1
ENST00000545118.1
 DAW1

dynein assembly factor with WDR repeat domains 1

chr3_-_50383096 91.956 ENST00000442887.1
ENST00000360165.3
 ZMYND10

zinc finger, MYND-type containing 10

chr11_+_111385497 91.352 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
 C11orf88


chromosome 11 open reading frame 88



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 189 entries
Log-likelihood per target Total log-likelihoodTermDescription
15.2 743.2 GO:0035082 axoneme assembly(GO:0035082)
21.1 675.2 GO:0044458 motile cilium assembly(GO:0044458)
5.8 291.7 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
1.2 278.9 GO:0060271 cilium morphogenesis(GO:0060271)
2.3 246.1 GO:0007368 determination of left/right symmetry(GO:0007368)
21.8 239.9 GO:0060294 cilium movement involved in cell motility(GO:0060294)
8.8 193.5 GO:0003341 cilium movement(GO:0003341)
1.3 159.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
3.6 135.4 GO:0071801 regulation of podosome assembly(GO:0071801)
2.6 122.1 GO:0048741 skeletal muscle fiber development(GO:0048741)
2.6 113.1 GO:0001578 microtubule bundle formation(GO:0001578)
1.5 104.9 GO:0021795 cerebral cortex cell migration(GO:0021795)
34.4 103.2 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
6.0 102.5 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
15.4 92.4 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
22.5 90.1 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.9 87.9 GO:0032418 lysosome localization(GO:0032418)
2.8 86.7 GO:0002021 response to dietary excess(GO:0002021)
0.6 85.5 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
4.1 78.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.1 792.7 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
34.6 414.8 GO:0072687 meiotic spindle(GO:0072687)
1.1 362.0 GO:0005929 cilium(GO:0005929)
10.9 314.9 GO:0030992 intraciliary transport particle B(GO:0030992)
43.3 303.4 GO:0002177 manchette(GO:0002177)
0.5 239.8 GO:0005874 microtubule(GO:0005874)
6.6 192.4 GO:0034451 centriolar satellite(GO:0034451)
2.2 188.6 GO:0036126 sperm flagellum(GO:0036126)
9.6 182.8 GO:0036038 MKS complex(GO:0036038)
0.2 170.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
3.1 166.3 GO:0009925 basal plasma membrane(GO:0009925)
46.0 137.9 GO:0001534 radial spoke(GO:0001534)
1.9 135.4 GO:0002102 podosome(GO:0002102)
2.2 134.7 GO:0005801 cis-Golgi network(GO:0005801)
1.6 128.2 GO:0036064 ciliary basal body(GO:0036064)
24.8 123.8 GO:0005879 axonemal microtubule(GO:0005879)
11.2 112.3 GO:0097427 microtubule bundle(GO:0097427)
0.3 109.0 GO:0005813 centrosome(GO:0005813)
4.1 95.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
23.1 92.5 GO:0097224 sperm connecting piece(GO:0097224)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 766.8 GO:0003674 molecular_function(GO:0003674)
0.4 408.8 GO:0005509 calcium ion binding(GO:0005509)
1.3 344.9 GO:0008017 microtubule binding(GO:0008017)
12.6 278.2 GO:0045504 dynein heavy chain binding(GO:0045504)
4.4 178.7 GO:0043015 gamma-tubulin binding(GO:0043015)
4.9 136.8 GO:0017160 Ral GTPase binding(GO:0017160)
1.7 136.3 GO:0003777 microtubule motor activity(GO:0003777)
0.3 134.6 GO:0005525 GTP binding(GO:0005525)
0.2 114.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
3.4 94.0 GO:0045505 dynein intermediate chain binding(GO:0045505)
1.6 93.8 GO:0030544 Hsp70 protein binding(GO:0030544)
7.1 92.5 GO:0032027 myosin light chain binding(GO:0032027)
3.0 78.0 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.7 77.3 GO:0051087 chaperone binding(GO:0051087)
0.6 75.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 66.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.2 62.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
1.1 60.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 60.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
2.5 57.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 51.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 43.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.5 39.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.5 35.9 PID_PLK1_PATHWAY PLK1 signaling events
0.2 30.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.6 29.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.6 24.9 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3 24.0 PID_TNF_PATHWAY TNF receptor signaling pathway
0.4 19.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.3 17.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 16.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 16.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 10.8 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 8.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 7.3 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 7.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 6.1 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 5.9 PID_ALK2_PATHWAY ALK2 signaling events
0.1 4.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 4.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 66.6 REACTOME_KINESINS Genes involved in Kinesins
2.2 58.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 39.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.6 34.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.5 34.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.5 29.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
1.6 29.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
1.1 29.1 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
1.2 24.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
1.0 17.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.6 15.9 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
1.0 14.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 14.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 9.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.3 8.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 8.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 8.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 8.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 7.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.7 7.6 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol