Motif ID: RFX5

Z-value: 1.526


Transcription factors associated with RFX5:

Gene SymbolEntrez IDGene Name
RFX5 ENSG00000143390.13 RFX5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319710_1513198330.452.9e-02Click!


Activity profile for motif RFX5.

activity profile for motif RFX5


Sorted Z-values histogram for motif RFX5

Sorted Z-values for motif RFX5



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_32557610 16.163 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_-_32498046 13.645 ENST00000374975.3
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr5_-_149792295 13.539 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
 CD74



CD74 molecule, major histocompatibility complex, class II invariant chain



chr6_-_32920794 8.809 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
 HLA-DMA


XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha


Uncharacterized protein
chr6_+_33043703 8.117 ENST00000418931.2
ENST00000535465.1
 HLA-DPB1

major histocompatibility complex, class II, DP beta 1

chr6_+_32821924 7.540 ENST00000374859.2
ENST00000453265.2
 PSMB9

proteasome (prosome, macropain) subunit, beta type, 9

chr11_+_111385497 7.536 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
 C11orf88


chromosome 11 open reading frame 88


chr10_+_82116529 6.203 ENST00000411538.1
ENST00000256039.2
 DYDC2

DPY30 domain containing 2

chr1_+_85527987 5.543 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
 WDR63


WD repeat domain 63


chr6_-_32634425 4.876 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
 HLA-DQB1



major histocompatibility complex, class II, DQ beta 1



chr6_+_32812568 4.874 ENST00000414474.1
 PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr17_-_19266045 4.537 ENST00000395616.3
 B9D1
B9 protein domain 1
chr6_-_32731299 4.298 ENST00000435145.2
ENST00000437316.2
 HLA-DQB2

major histocompatibility complex, class II, DQ beta 2

chr8_+_101170257 4.293 ENST00000251809.3
 SPAG1
sperm associated antigen 1
chr1_+_36549676 4.100 ENST00000207457.3
 TEKT2
tektin 2 (testicular)
chr6_-_32908792 4.015 ENST00000418107.2
 HLA-DMB
major histocompatibility complex, class II, DM beta
chrX_+_125953746 3.754 ENST00000371125.3
 CXorf64
chromosome X open reading frame 64
chr10_-_82116497 3.255 ENST00000372204.3
 DYDC1
DPY30 domain containing 1
chr17_-_19265855 3.254 ENST00000440841.1
ENST00000395615.1
ENST00000461069.2
 B9D1


B9 protein domain 1


chr10_-_82116505 3.099 ENST00000372202.1
ENST00000421924.2
ENST00000453477.1
 DYDC1


DPY30 domain containing 1


chr17_-_19265982 3.031 ENST00000268841.6
ENST00000261499.4
ENST00000575478.1
 B9D1


B9 protein domain 1


chr3_-_27410847 2.662 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
 NEK10


NIMA-related kinase 10


chr19_+_10527449 2.510 ENST00000592685.1
ENST00000380702.2
 PDE4A

phosphodiesterase 4A, cAMP-specific

chr1_-_27339317 2.423 ENST00000289166.5
 FAM46B
family with sequence similarity 46, member B
chr10_-_82116467 2.378 ENST00000454362.1
 DYDC1
DPY30 domain containing 1
chr11_+_45868957 2.251 ENST00000443527.2
 CRY2
cryptochrome 2 (photolyase-like)
chr11_-_118436606 2.020 ENST00000530872.1
 IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr6_-_32812420 2.003 ENST00000374881.2
 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr11_-_118436707 1.852 ENST00000264020.2
ENST00000264021.3
 IFT46

intraflagellar transport 46 homolog (Chlamydomonas)

chr6_+_26440700 1.714 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
 BTN3A3









butyrophilin, subfamily 3, member A3









chr19_+_10563567 1.518 ENST00000344979.3
 PDE4A
phosphodiesterase 4A, cAMP-specific
chr12_-_110841462 1.452 ENST00000455511.3
ENST00000450008.2
 ANAPC7

anaphase promoting complex subunit 7

chr1_+_46049706 1.300 ENST00000527470.1
ENST00000525515.1
ENST00000537798.1
ENST00000402363.3
ENST00000528238.1
ENST00000350030.3
ENST00000470768.1
ENST00000372052.4
ENST00000351223.3
 NASP








nuclear autoantigenic sperm protein (histone-binding)








chr11_-_6640585 1.281 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
 TPP1



tripeptidyl peptidase I



chr13_-_30424821 1.256 ENST00000380680.4
 UBL3
ubiquitin-like 3
chr6_+_26365443 1.202 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
 BTN3A2





butyrophilin, subfamily 3, member A2





chr1_+_150254936 1.156 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
 C1orf51


chromosome 1 open reading frame 51


chr6_-_32731243 1.122 ENST00000427449.1
ENST00000411527.1
 HLA-DQB2

major histocompatibility complex, class II, DQ beta 2

chr16_+_67381263 1.031 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
 LRRC36


leucine rich repeat containing 36


chr22_+_31518938 1.012 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
 INPP5J






inositol polyphosphate-5-phosphatase J






chr11_-_85430088 0.965 ENST00000533057.1
ENST00000533892.1
 SYTL2

synaptotagmin-like 2

chr4_-_83719884 0.962 ENST00000282709.4
ENST00000273908.4
 SCD5

stearoyl-CoA desaturase 5

chr16_+_67381289 0.906 ENST00000435835.3
 LRRC36
leucine rich repeat containing 36
chr6_+_26383318 0.796 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
 BTN2A2








butyrophilin, subfamily 2, member A2








chr11_-_72433346 0.762 ENST00000334211.8
 ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_+_26383404 0.698 ENST00000416795.2
ENST00000494184.1
 BTN2A2

butyrophilin, subfamily 2, member A2

chr6_+_26458152 0.693 ENST00000312541.5
 BTN2A1
butyrophilin, subfamily 2, member A1
chr6_-_32908765 0.642 ENST00000416244.2
 HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_-_24667180 0.617 ENST00000545995.1
 TDP2
tyrosyl-DNA phosphodiesterase 2
chr2_-_242088850 0.578 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
 PASK





PAS domain containing serine/threonine kinase





chr15_+_45003675 0.525 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
 B2M


beta-2-microglobulin


chr8_-_99306564 0.513 ENST00000430223.2
 NIPAL2
NIPA-like domain containing 2
chr6_-_24666819 0.479 ENST00000341060.3
 TDP2
tyrosyl-DNA phosphodiesterase 2
chr8_-_99306611 0.383 ENST00000341166.3
 NIPAL2
NIPA-like domain containing 2
chr1_+_249132462 0.382 ENST00000306562.3
 ZNF672
zinc finger protein 672
chr5_-_55412774 0.369 ENST00000434982.2
 ANKRD55
ankyrin repeat domain 55
chr6_-_30181133 0.351 ENST00000454678.2
ENST00000434785.1
 TRIM26

tripartite motif containing 26

chrX_+_19362011 0.328 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
 PDHA1







pyruvate dehydrogenase (lipoamide) alpha 1







chr6_-_30181156 0.322 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
 TRIM26


tripartite motif containing 26


chr3_+_43328004 0.317 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
 SNRK



SNF related kinase



chr17_+_38137073 0.251 ENST00000541736.1
 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr20_+_42875887 0.248 ENST00000342560.5
 GDAP1L1
ganglioside induced differentiation associated protein 1-like 1
chr10_+_14880287 0.220 ENST00000437161.2
 HSPA14
heat shock 70kDa protein 14
chr10_+_14880157 0.197 ENST00000378372.3
 HSPA14
heat shock 70kDa protein 14
chr20_+_42875935 0.160 ENST00000438466.1
ENST00000372952.3
ENST00000537864.1
ENST00000445952.1
 GDAP1L1



ganglioside induced differentiation associated protein 1-like 1



chr16_-_74808710 0.153 ENST00000219368.3
ENST00000544337.1
 FA2H

fatty acid 2-hydroxylase

chr2_-_105030466 0.149 ENST00000449772.1
 AC068535.3
AC068535.3
chr17_+_30348024 0.110 ENST00000327564.7
ENST00000584368.1
ENST00000394713.3
ENST00000341671.7
 LRRC37B



leucine rich repeat containing 37B



chr5_+_79615790 0.020 ENST00000296739.4
 SPZ1
spermatogenic leucine zipper 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 29.6 GO:0002399 MHC class II protein complex assembly(GO:0002399)
2.7 13.5 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.1 14.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.8 2.3 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.3 1.0 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3 4.1 GO:0036159 inner dynein arm assembly(GO:0036159)
0.2 31.5 GO:0031295 T cell costimulation(GO:0031295)
0.2 4.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.2 0.8 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.2 0.5 GO:1903989 positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.2 7.5 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.1 1.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 14.0 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 10.8 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.1 4.0 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.1 0.4 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 1.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 0.6 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 3.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 1.0 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 2.7 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 1.2 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.9 GO:0015693 magnesium ion transport(GO:0015693)
0.0 1.0 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 1.3 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 5.5 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.2 GO:0048733 peripheral nervous system myelin maintenance(GO:0032287) sebaceous gland development(GO:0048733)
0.0 1.7 GO:0002456 T cell mediated immunity(GO:0002456)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 73.8 GO:0042613 MHC class II protein complex(GO:0042613)
1.6 14.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.7 14.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.6 10.8 GO:0036038 MKS complex(GO:0036038)
0.1 3.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.5 GO:0031905 early endosome lumen(GO:0031905)
0.1 5.5 GO:0030286 dynein complex(GO:0030286)
0.0 1.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 4.1 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 4.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.5 GO:1902911 protein kinase complex(GO:1902911)
0.0 2.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 13.5 GO:0042289 MHC class II protein binding(GO:0042289)
1.2 10.8 GO:0008158 hedgehog receptor activity(GO:0008158)
1.1 42.6 GO:0042605 peptide antigen binding(GO:0042605)
0.8 4.0 GO:0032395 MHC class II receptor activity(GO:0032395)
0.6 14.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.5 13.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.5 14.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 1.1 GO:0070260 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
0.3 5.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 1.3 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.2 1.0 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1 2.3 GO:0009881 photoreceptor activity(GO:0009881)
0.1 1.0 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 4.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.3 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.8 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 3.9 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.1 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 37.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 14.0 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 25.6 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 0.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.5 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 2.3 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)