Motif ID: RFX7_RFX4_RFX1

Z-value: 11.337

Transcription factors associated with RFX7_RFX4_RFX1:

Gene SymbolEntrez IDGene Name
RFX1 ENSG00000132005.4 RFX1
RFX4 ENSG00000111783.8 RFX4
RFX7 ENSG00000181827.10 RFX7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RFX7hg19_v2_chr15_-_56535464_56535521-0.462.5e-02Click!
RFX1hg19_v2_chr19_-_14117074_14117141-0.252.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of RFX7_RFX4_RFX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_55888186 195.079 ENST00000291934.3
TMEM190
transmembrane protein 190
chr1_-_109655355 105.649 ENST00000369945.3
C1orf194
chromosome 1 open reading frame 194
chr1_-_109655377 105.217 ENST00000369948.3
C1orf194
chromosome 1 open reading frame 194
chr1_-_161337662 101.218 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr10_+_23216944 83.831 ENST00000298032.5
ENST00000409983.3
ENST00000409049.3
ARMC3


armadillo repeat containing 3


chr9_-_138391692 83.734 ENST00000429260.2
C9orf116
chromosome 9 open reading frame 116
chr10_+_23217006 81.721 ENST00000376528.4
ENST00000447081.1
ARMC3

armadillo repeat containing 3

chr10_-_25305011 77.147 ENST00000331161.4
ENST00000376363.1
ENKUR

enkurin, TRPC channel interacting protein

chr16_+_80574854 76.088 ENST00000305904.6
ENST00000568035.1
DYNLRB2

dynein, light chain, roadblock-type 2

chr6_+_163148973 74.336 ENST00000366888.2
PACRG
PARK2 co-regulated
chr20_+_56725952 69.610 ENST00000371168.3
C20orf85
chromosome 20 open reading frame 85
chr22_-_23484246 67.944 ENST00000216036.4
RTDR1
rhabdoid tumor deletion region gene 1
chr21_-_43916433 67.928 ENST00000291536.3
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr22_+_23487513 66.916 ENST00000263116.2
ENST00000341989.4
RAB36

RAB36, member RAS oncogene family

chr1_+_36549676 65.869 ENST00000207457.3
TEKT2
tektin 2 (testicular)
chr1_+_85527987 64.779 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63


WD repeat domain 63


chr21_-_43916296 64.060 ENST00000398352.3
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr9_-_34381536 61.682 ENST00000379126.3
ENST00000379127.1
ENST00000379133.3
C9orf24


chromosome 9 open reading frame 24


chr9_-_34381511 61.037 ENST00000379124.1
C9orf24
chromosome 9 open reading frame 24
chr22_-_50970919 59.379 ENST00000329363.4
ENST00000437588.1
ODF3B

outer dense fiber of sperm tails 3B


Gene overrepresentation in biological_process category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.8 300.8 GO:0035082 axoneme assembly(GO:0035082)
4.3 286.1 GO:0042073 intraciliary transport(GO:0042073)
11.5 241.8 GO:0036158 outer dynein arm assembly(GO:0036158)
0.5 186.0 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
1.3 162.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.7 158.1 GO:0060271 cilium morphogenesis(GO:0060271)
32.8 131.1 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
8.9 124.3 GO:0006348 chromatin silencing at telomere(GO:0006348)
7.9 110.6 GO:0003351 epithelial cilium movement(GO:0003351)
5.3 105.9 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
14.1 98.8 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
5.1 91.8 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
14.4 86.5 GO:0036159 inner dynein arm assembly(GO:0036159)
0.5 77.0 GO:0007286 spermatid development(GO:0007286)
0.6 65.8 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
16.3 65.2 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
3.3 61.9 GO:0003341 cilium movement(GO:0003341)
14.9 59.8 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
1.0 57.2 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.3 53.1 GO:0007018 microtubule-based movement(GO:0007018)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 297.9 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
12.3 234.5 GO:0036038 MKS complex(GO:0036038)
19.8 218.1 GO:0036157 outer dynein arm(GO:0036157)
39.0 195.1 GO:0002079 inner acrosomal membrane(GO:0002079)
0.6 150.5 GO:0005929 cilium(GO:0005929)
5.0 144.8 GO:0030992 intraciliary transport particle B(GO:0030992)
2.4 134.2 GO:0036126 sperm flagellum(GO:0036126)
6.2 130.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
10.7 128.9 GO:0072687 meiotic spindle(GO:0072687)
2.0 110.5 GO:0009925 basal plasma membrane(GO:0009925)
13.5 94.6 GO:0002177 manchette(GO:0002177)
4.1 85.5 GO:0042613 MHC class II protein complex(GO:0042613)
1.8 76.3 GO:0030286 dynein complex(GO:0030286)
4.1 74.3 GO:0097225 sperm midpiece(GO:0097225)
1.0 72.2 GO:0036064 ciliary basal body(GO:0036064)
2.6 69.8 GO:0097228 sperm principal piece(GO:0097228)
0.1 64.3 GO:0005813 centrosome(GO:0005813)
1.0 61.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
11.6 57.8 GO:0005879 axonemal microtubule(GO:0005879)
1.4 57.2 GO:0031514 motile cilium(GO:0031514)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.4 228.6 GO:0045504 dynein heavy chain binding(GO:0045504)
2.4 196.6 GO:0043621 protein self-association(GO:0043621)
0.3 153.6 GO:0005525 GTP binding(GO:0005525)
5.4 149.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
2.8 147.2 GO:0048487 beta-tubulin binding(GO:0048487)
5.4 130.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
11.8 105.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
3.7 91.8 GO:0031005 filamin binding(GO:0031005)
0.3 82.7 GO:0008017 microtubule binding(GO:0008017)
5.6 78.6 GO:0032395 MHC class II receptor activity(GO:0032395)
3.1 74.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 69.1 GO:0017124 SH3 domain binding(GO:0017124)
5.7 56.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.7 52.6 GO:0003777 microtubule motor activity(GO:0003777)
0.1 49.3 GO:0005509 calcium ion binding(GO:0005509)
6.8 47.5 GO:0004127 cytidylate kinase activity(GO:0004127)
4.8 33.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.7 29.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.6 28.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.6 26.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 92.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
1.0 51.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 30.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.4 28.6 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.3 19.2 PID_PLK1_PATHWAY PLK1 signaling events
0.2 14.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.7 6.6 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.1 6.0 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 5.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.4 5.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 5.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 4.9 PID_E2F_PATHWAY E2F transcription factor network
0.2 4.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.0 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 3.9 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.4 3.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.1 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 2.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.1 PID_P73PATHWAY p73 transcription factor network
0.1 1.8 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 41.5 REACTOME_KINESINS Genes involved in Kinesins
0.4 34.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
1.1 28.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.4 25.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.0 22.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 16.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.3 9.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.5 9.0 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.3 7.1 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 5.4 REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.1 5.3 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 4.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 4.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 4.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 3.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 3.7 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 2.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.8 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 2.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases