Motif ID: RFX7_RFX4_RFX1
Z-value: 11.337



Transcription factors associated with RFX7_RFX4_RFX1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
RFX1 | ENSG00000132005.4 | RFX1 |
RFX4 | ENSG00000111783.8 | RFX4 |
RFX7 | ENSG00000181827.10 | RFX7 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
RFX7 | hg19_v2_chr15_-_56535464_56535521 | -0.46 | 2.5e-02 | Click! |
RFX1 | hg19_v2_chr19_-_14117074_14117141 | -0.25 | 2.4e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 201 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
8.8 | 300.8 | GO:0035082 | axoneme assembly(GO:0035082) |
4.3 | 286.1 | GO:0042073 | intraciliary transport(GO:0042073) |
11.5 | 241.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
0.5 | 186.0 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
1.3 | 162.2 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
0.7 | 158.1 | GO:0060271 | cilium morphogenesis(GO:0060271) |
32.8 | 131.1 | GO:0090299 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
8.9 | 124.3 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
7.9 | 110.6 | GO:0003351 | epithelial cilium movement(GO:0003351) |
5.3 | 105.9 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
14.1 | 98.8 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
5.1 | 91.8 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
14.4 | 86.5 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
0.5 | 77.0 | GO:0007286 | spermatid development(GO:0007286) |
0.6 | 65.8 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
16.3 | 65.2 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
3.3 | 61.9 | GO:0003341 | cilium movement(GO:0003341) |
14.9 | 59.8 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
1.0 | 57.2 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
0.3 | 53.1 | GO:0007018 | microtubule-based movement(GO:0007018) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 115 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.5 | 297.9 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
12.3 | 234.5 | GO:0036038 | MKS complex(GO:0036038) |
19.8 | 218.1 | GO:0036157 | outer dynein arm(GO:0036157) |
39.0 | 195.1 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
0.6 | 150.5 | GO:0005929 | cilium(GO:0005929) |
5.0 | 144.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
2.4 | 134.2 | GO:0036126 | sperm flagellum(GO:0036126) |
6.2 | 130.8 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
10.7 | 128.9 | GO:0072687 | meiotic spindle(GO:0072687) |
2.0 | 110.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
13.5 | 94.6 | GO:0002177 | manchette(GO:0002177) |
4.1 | 85.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
1.8 | 76.3 | GO:0030286 | dynein complex(GO:0030286) |
4.1 | 74.3 | GO:0097225 | sperm midpiece(GO:0097225) |
1.0 | 72.2 | GO:0036064 | ciliary basal body(GO:0036064) |
2.6 | 69.8 | GO:0097228 | sperm principal piece(GO:0097228) |
0.1 | 64.3 | GO:0005813 | centrosome(GO:0005813) |
1.0 | 61.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
11.6 | 57.8 | GO:0005879 | axonemal microtubule(GO:0005879) |
1.4 | 57.2 | GO:0031514 | motile cilium(GO:0031514) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 136 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
10.4 | 228.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
2.4 | 196.6 | GO:0043621 | protein self-association(GO:0043621) |
0.3 | 153.6 | GO:0005525 | GTP binding(GO:0005525) |
5.4 | 149.9 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
2.8 | 147.2 | GO:0048487 | beta-tubulin binding(GO:0048487) |
5.4 | 130.8 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
11.8 | 105.9 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
3.7 | 91.8 | GO:0031005 | filamin binding(GO:0031005) |
0.3 | 82.7 | GO:0008017 | microtubule binding(GO:0008017) |
5.6 | 78.6 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
3.1 | 74.8 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.3 | 69.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
5.7 | 56.5 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
0.7 | 52.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.1 | 49.3 | GO:0005509 | calcium ion binding(GO:0005509) |
6.8 | 47.5 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
4.8 | 33.8 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
0.7 | 29.7 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
0.6 | 28.9 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
0.6 | 26.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 26 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 92.6 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
1.0 | 51.9 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
0.1 | 30.7 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
0.4 | 28.6 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
0.3 | 19.2 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.2 | 14.4 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
0.7 | 6.6 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
0.1 | 6.0 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
0.1 | 5.8 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.4 | 5.7 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.2 | 5.6 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 4.9 | PID_E2F_PATHWAY | E2F transcription factor network |
0.2 | 4.6 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.1 | 4.0 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
0.1 | 3.9 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.4 | 3.8 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.1 | 3.1 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.1 | 2.1 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
0.0 | 2.1 | PID_P73PATHWAY | p73 transcription factor network |
0.1 | 1.8 | PID_IL3_PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 36 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 41.5 | REACTOME_KINESINS | Genes involved in Kinesins |
0.4 | 34.3 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
1.1 | 28.6 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.4 | 25.4 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
1.0 | 22.6 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.3 | 16.8 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
0.3 | 9.7 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
0.5 | 9.0 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
0.3 | 7.1 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
0.1 | 5.4 | REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
0.1 | 5.3 | REACTOME_IRON_UPTAKE_AND_TRANSPORT | Genes involved in Iron uptake and transport |
0.1 | 4.8 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
0.1 | 4.8 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.1 | 4.8 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.2 | 4.5 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.3 | 3.8 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
0.2 | 3.7 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
0.0 | 2.9 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.1 | 2.8 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
0.0 | 2.5 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |