Motif ID: RFX7_RFX4_RFX1
Z-value: 11.337
Transcription factors associated with RFX7_RFX4_RFX1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| RFX1 | ENSG00000132005.4 | RFX1 |
| RFX4 | ENSG00000111783.8 | RFX4 |
| RFX7 | ENSG00000181827.10 | RFX7 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX7 | hg19_v2_chr15_-_56535464_56535521 | -0.46 | 2.5e-02 | Click! |
| RFX1 | hg19_v2_chr19_-_14117074_14117141 | -0.25 | 2.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 32.8 | 131.1 | GO:0090299 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 16.3 | 65.2 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 14.9 | 59.8 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 14.4 | 86.5 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 14.1 | 98.8 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 11.5 | 241.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 9.6 | 28.7 | GO:0050902 | leukocyte adhesive activation(GO:0050902) |
| 8.9 | 124.3 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 8.8 | 300.8 | GO:0035082 | axoneme assembly(GO:0035082) |
| 7.9 | 110.6 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 6.6 | 19.7 | GO:0006174 | dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571) |
| 5.3 | 105.9 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 5.1 | 91.8 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 5.0 | 15.1 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 4.9 | 14.6 | GO:0032203 | telomere formation via telomerase(GO:0032203) |
| 4.5 | 40.8 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 4.4 | 26.4 | GO:0032185 | regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185) glomerular visceral epithelial cell migration(GO:0090521) |
| 4.3 | 4.3 | GO:0018307 | enzyme active site formation(GO:0018307) |
| 4.3 | 286.1 | GO:0042073 | intraciliary transport(GO:0042073) |
| 3.6 | 14.2 | GO:0018094 | protein polyglycylation(GO:0018094) |
| 3.5 | 10.4 | GO:1903568 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 3.3 | 16.7 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 3.3 | 61.9 | GO:0003341 | cilium movement(GO:0003341) |
| 3.1 | 9.4 | GO:0018057 | peptidyl-lysine oxidation(GO:0018057) |
| 3.0 | 14.8 | GO:0061009 | common bile duct development(GO:0061009) |
| 2.9 | 20.0 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 2.5 | 12.3 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 2.4 | 33.8 | GO:0006108 | malate metabolic process(GO:0006108) |
| 2.2 | 38.0 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 2.2 | 35.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 2.1 | 17.0 | GO:1903751 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 2.0 | 18.1 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 2.0 | 4.0 | GO:0023021 | termination of signal transduction(GO:0023021) |
| 2.0 | 7.8 | GO:2001178 | mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178) |
| 1.9 | 5.6 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 1.6 | 3.3 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) |
| 1.5 | 4.6 | GO:0006788 | heme oxidation(GO:0006788) smooth muscle hyperplasia(GO:0014806) negative regulation of mast cell cytokine production(GO:0032764) |
| 1.3 | 162.2 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 1.2 | 3.7 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 1.2 | 20.8 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 1.2 | 12.0 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 1.2 | 7.1 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 1.2 | 4.7 | GO:2000729 | positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729) |
| 1.1 | 43.3 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 1.1 | 6.6 | GO:0043305 | negative regulation of mast cell degranulation(GO:0043305) |
| 1.0 | 3.1 | GO:1904395 | retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 1.0 | 1.0 | GO:0045875 | negative regulation of sister chromatid cohesion(GO:0045875) |
| 1.0 | 3.1 | GO:1902214 | negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) regulation of interleukin-4-mediated signaling pathway(GO:1902214) |
| 1.0 | 28.6 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 1.0 | 57.2 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 1.0 | 21.4 | GO:0003334 | keratinocyte development(GO:0003334) |
| 1.0 | 19.3 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.9 | 11.4 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.9 | 1.9 | GO:0009212 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) |
| 0.9 | 3.5 | GO:0061511 | centriole elongation(GO:0061511) |
| 0.8 | 2.5 | GO:0031247 | actin rod assembly(GO:0031247) |
| 0.8 | 6.6 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.8 | 3.3 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.8 | 19.9 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.8 | 6.3 | GO:0070092 | negative regulation of glycogen biosynthetic process(GO:0045719) regulation of glucagon secretion(GO:0070092) |
| 0.8 | 1.6 | GO:0072717 | cellular response to actinomycin D(GO:0072717) |
| 0.8 | 2.3 | GO:0021888 | hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) |
| 0.7 | 2.2 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 0.7 | 7.1 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.7 | 9.9 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.7 | 158.1 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.7 | 2.0 | GO:1902869 | commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898) negative regulation of photoreceptor cell differentiation(GO:0046533) regulation of amacrine cell differentiation(GO:1902869) |
| 0.6 | 1.3 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 0.6 | 2.5 | GO:0003094 | glomerular filtration(GO:0003094) renal filtration(GO:0097205) |
| 0.6 | 8.2 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.6 | 3.8 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.6 | 10.0 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.6 | 3.7 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.6 | 2.5 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 0.6 | 7.8 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.6 | 6.5 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.6 | 1.8 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 0.6 | 2.3 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.6 | 9.8 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.6 | 65.8 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.6 | 1.7 | GO:2001160 | histone H3-K79 methylation(GO:0034729) regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162) |
| 0.5 | 37.7 | GO:0021795 | cerebral cortex cell migration(GO:0021795) |
| 0.5 | 186.0 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.5 | 1.1 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 0.5 | 3.8 | GO:0030242 | pexophagy(GO:0030242) |
| 0.5 | 15.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.5 | 77.0 | GO:0007286 | spermatid development(GO:0007286) |
| 0.5 | 8.1 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.5 | 37.0 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.5 | 0.9 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.4 | 2.2 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.4 | 5.3 | GO:0032990 | cell part morphogenesis(GO:0032990) |
| 0.4 | 9.9 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.4 | 2.1 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.4 | 1.6 | GO:0035553 | oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.4 | 3.9 | GO:1902116 | negative regulation of organelle assembly(GO:1902116) |
| 0.4 | 2.9 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.4 | 2.5 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) |
| 0.3 | 2.1 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.3 | 8.1 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.3 | 1.8 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.3 | 3.0 | GO:0010833 | telomere maintenance via telomere lengthening(GO:0010833) |
| 0.3 | 6.0 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.3 | 2.8 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.3 | 1.1 | GO:1902361 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 0.3 | 7.4 | GO:0002021 | response to dietary excess(GO:0002021) |
| 0.3 | 2.1 | GO:0046520 | sphingoid biosynthetic process(GO:0046520) |
| 0.3 | 53.1 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.3 | 1.6 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.3 | 1.3 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
| 0.3 | 1.5 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) |
| 0.3 | 1.0 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.2 | 3.5 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.2 | 1.7 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.2 | 4.4 | GO:2000059 | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059) |
| 0.2 | 21.2 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 0.2 | 6.9 | GO:0043949 | regulation of cAMP-mediated signaling(GO:0043949) |
| 0.2 | 5.4 | GO:0019216 | regulation of lipid metabolic process(GO:0019216) |
| 0.2 | 36.7 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.2 | 2.0 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.2 | 1.7 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.2 | 6.0 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.2 | 0.9 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.2 | 1.1 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.2 | 1.7 | GO:0042797 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 0.2 | 27.0 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.2 | 0.8 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 0.2 | 1.0 | GO:0006293 | nucleotide-excision repair, preincision complex stabilization(GO:0006293) |
| 0.2 | 1.0 | GO:1904431 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) positive regulation of t-circle formation(GO:1904431) |
| 0.2 | 0.4 | GO:1905232 | cellular response to L-glutamate(GO:1905232) |
| 0.2 | 7.0 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.2 | 1.7 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.2 | 0.9 | GO:2000172 | regulation of branching morphogenesis of a nerve(GO:2000172) |
| 0.2 | 0.9 | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) |
| 0.2 | 1.2 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.2 | 1.0 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.2 | 11.4 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.2 | 0.3 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.2 | 1.1 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.2 | 1.1 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 2.4 | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241) |
| 0.1 | 1.8 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.1 | 4.7 | GO:0010165 | response to X-ray(GO:0010165) |
| 0.1 | 3.4 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.1 | 1.3 | GO:0000492 | box C/D snoRNP assembly(GO:0000492) |
| 0.1 | 1.2 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.1 | 2.8 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.1 | 12.0 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.1 | 3.7 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.1 | 4.9 | GO:0042407 | cristae formation(GO:0042407) |
| 0.1 | 0.7 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 1.4 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.1 | 1.2 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
| 0.1 | 0.5 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.1 | 0.4 | GO:0010836 | base-excision repair, DNA ligation(GO:0006288) negative regulation of protein ADP-ribosylation(GO:0010836) regulation of single strand break repair(GO:1903516) |
| 0.1 | 1.4 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.1 | 2.6 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.1 | 9.7 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.1 | 3.2 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 0.1 | 12.2 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.1 | 2.5 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.1 | 1.5 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 6.0 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.1 | 2.8 | GO:0006631 | fatty acid metabolic process(GO:0006631) |
| 0.1 | 8.4 | GO:0001942 | hair follicle development(GO:0001942) |
| 0.1 | 2.0 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 0.4 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.1 | 0.3 | GO:0098707 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.1 | 2.3 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.1 | 0.3 | GO:0090385 | phagosome-lysosome fusion(GO:0090385) |
| 0.1 | 4.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 0.4 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.1 | 0.8 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
| 0.1 | 40.3 | GO:0031344 | regulation of cell projection organization(GO:0031344) |
| 0.1 | 1.0 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.1 | 0.2 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.0 | 4.3 | GO:0051492 | regulation of stress fiber assembly(GO:0051492) |
| 0.0 | 0.3 | GO:0032380 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 0.0 | 2.0 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 0.3 | GO:0051571 | positive regulation of histone H3-K4 methylation(GO:0051571) |
| 0.0 | 0.5 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.0 | 1.5 | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.0 | 1.1 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 1.0 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 0.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.1 | GO:0043686 | co-translational protein modification(GO:0043686) |
| 0.0 | 0.2 | GO:1903299 | regulation of glucokinase activity(GO:0033131) regulation of hexokinase activity(GO:1903299) |
| 0.0 | 1.6 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.0 | 1.5 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.0 | 1.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.4 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 1.8 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.7 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 2.4 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.0 | 0.4 | GO:0030207 | chondroitin sulfate catabolic process(GO:0030207) |
| 0.0 | 0.2 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.0 | 0.2 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.2 | GO:0015698 | inorganic anion transport(GO:0015698) |
| 0.0 | 0.5 | GO:0045026 | plasma membrane fusion(GO:0045026) |
| 0.0 | 0.1 | GO:0036111 | very long-chain fatty-acyl-CoA metabolic process(GO:0036111) |
| 0.0 | 0.1 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 39.0 | 195.1 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 19.8 | 218.1 | GO:0036157 | outer dynein arm(GO:0036157) |
| 15.9 | 47.8 | GO:0001534 | radial spoke(GO:0001534) |
| 13.5 | 94.6 | GO:0002177 | manchette(GO:0002177) |
| 12.3 | 234.5 | GO:0036038 | MKS complex(GO:0036038) |
| 11.6 | 57.8 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 10.7 | 128.9 | GO:0072687 | meiotic spindle(GO:0072687) |
| 6.7 | 20.1 | GO:1990716 | axonemal central apparatus(GO:1990716) |
| 6.2 | 130.8 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 5.6 | 5.6 | GO:0030990 | intraciliary transport particle(GO:0030990) |
| 5.4 | 16.2 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 5.0 | 144.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 4.4 | 44.5 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 4.1 | 74.3 | GO:0097225 | sperm midpiece(GO:0097225) |
| 4.1 | 41.3 | GO:0044447 | axoneme part(GO:0044447) |
| 4.1 | 85.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 4.0 | 20.0 | GO:0098536 | deuterosome(GO:0098536) |
| 3.9 | 15.7 | GO:0016939 | kinesin II complex(GO:0016939) |
| 3.7 | 29.7 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 3.5 | 297.9 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 2.6 | 69.8 | GO:0097228 | sperm principal piece(GO:0097228) |
| 2.4 | 134.2 | GO:0036126 | sperm flagellum(GO:0036126) |
| 2.4 | 21.2 | GO:0034464 | BBSome(GO:0034464) |
| 2.2 | 37.6 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 2.0 | 110.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 1.8 | 76.3 | GO:0030286 | dynein complex(GO:0030286) |
| 1.4 | 57.2 | GO:0031514 | motile cilium(GO:0031514) |
| 1.0 | 61.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 1.0 | 72.2 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.9 | 6.5 | GO:0000836 | Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.8 | 22.9 | GO:0097546 | ciliary base(GO:0097546) |
| 0.8 | 6.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.7 | 2.1 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.7 | 41.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.6 | 10.8 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.6 | 17.0 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.6 | 4.9 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.6 | 14.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.6 | 150.5 | GO:0005929 | cilium(GO:0005929) |
| 0.5 | 6.5 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.5 | 2.5 | GO:0070695 | FHF complex(GO:0070695) |
| 0.5 | 2.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.4 | 2.2 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.4 | 1.7 | GO:0055087 | Ski complex(GO:0055087) |
| 0.4 | 2.3 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.4 | 14.6 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.4 | 0.7 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.3 | 1.0 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.3 | 1.5 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.3 | 3.8 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 0.3 | 2.1 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.3 | 3.7 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.3 | 6.0 | GO:1902911 | protein kinase complex(GO:1902911) |
| 0.3 | 17.7 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 1.2 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.2 | 1.7 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.2 | 2.6 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.2 | 1.9 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.2 | 2.5 | GO:0070938 | contractile ring(GO:0070938) |
| 0.2 | 1.7 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.2 | 1.2 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.2 | 2.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.2 | 1.4 | GO:0070522 | ERCC4-ERCC1 complex(GO:0070522) |
| 0.2 | 7.7 | GO:0030496 | midbody(GO:0030496) |
| 0.2 | 4.0 | GO:0042599 | lamellar body(GO:0042599) |
| 0.2 | 7.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 1.9 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 0.6 | GO:0031085 | BLOC-3 complex(GO:0031085) |
| 0.1 | 6.6 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 64.3 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 1.3 | GO:0070761 | PCAF complex(GO:0000125) pre-snoRNP complex(GO:0070761) |
| 0.1 | 1.8 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 22.5 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 1.3 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 8.2 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.1 | 16.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 1.0 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 4.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 2.9 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 5.8 | GO:0097610 | cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610) |
| 0.1 | 7.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 2.1 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 2.7 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.1 | 1.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 2.0 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.1 | 0.3 | GO:0032021 | NELF complex(GO:0032021) |
| 0.1 | 2.3 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.1 | 7.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 3.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.4 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 5.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 6.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 2.1 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 2.0 | GO:1902555 | endoribonuclease complex(GO:1902555) |
| 0.0 | 1.1 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 38.1 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 1.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.4 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 5.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 0.5 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 3.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 5.7 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 3.4 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 21.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 3.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.7 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.0 | 1.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.1 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.0 | 3.2 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.3 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 1.4 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 0.9 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.0 | 0.4 | GO:0045171 | intercellular bridge(GO:0045171) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.8 | 105.9 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 10.4 | 228.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 8.3 | 24.9 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 6.8 | 47.5 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
| 5.7 | 56.5 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 5.6 | 78.6 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 5.4 | 130.8 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 5.4 | 149.9 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 5.0 | 15.1 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 4.8 | 33.8 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 3.7 | 91.8 | GO:0031005 | filamin binding(GO:0031005) |
| 3.3 | 10.0 | GO:0070991 | medium-chain-acyl-CoA dehydrogenase activity(GO:0070991) |
| 3.3 | 9.9 | GO:0033858 | N-acetylgalactosamine kinase activity(GO:0033858) |
| 3.1 | 74.8 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 2.8 | 147.2 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 2.7 | 16.3 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 2.4 | 196.6 | GO:0043621 | protein self-association(GO:0043621) |
| 2.4 | 14.2 | GO:0070735 | protein-glycine ligase activity(GO:0070735) |
| 1.9 | 9.4 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 1.8 | 9.0 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 1.5 | 4.6 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 1.2 | 11.8 | GO:0031433 | telethonin binding(GO:0031433) |
| 1.1 | 6.8 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 1.1 | 5.6 | GO:0016215 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 1.1 | 6.5 | GO:0039552 | RIG-I binding(GO:0039552) |
| 1.1 | 3.2 | GO:0071566 | UFM1 activating enzyme activity(GO:0071566) |
| 1.0 | 3.1 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 1.0 | 17.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 1.0 | 7.0 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.9 | 5.4 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.8 | 3.1 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.7 | 4.3 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.7 | 29.7 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.7 | 52.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.7 | 16.0 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.6 | 28.9 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.6 | 26.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.6 | 2.8 | GO:0004905 | type I interferon receptor activity(GO:0004905) |
| 0.5 | 7.0 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.5 | 2.5 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 0.5 | 7.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.5 | 15.3 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.5 | 18.6 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.5 | 2.3 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.5 | 1.4 | GO:0003943 | N-acetylgalactosamine-4-sulfatase activity(GO:0003943) |
| 0.4 | 1.7 | GO:0004948 | calcitonin receptor activity(GO:0004948) calcitonin receptor binding(GO:0031716) |
| 0.4 | 2.1 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.4 | 19.4 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.4 | 1.6 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.4 | 2.0 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.4 | 1.5 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.4 | 6.0 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.4 | 14.6 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.4 | 9.8 | GO:0005112 | Notch binding(GO:0005112) |
| 0.4 | 2.5 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.4 | 1.1 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) phosphatidylserine decarboxylase activity(GO:0004609) L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 0.4 | 2.1 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.3 | 1.7 | GO:0008422 | glucosylceramidase activity(GO:0004348) beta-glucosidase activity(GO:0008422) |
| 0.3 | 6.5 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.3 | 69.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.3 | 12.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.3 | 17.7 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.3 | 82.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.3 | 3.7 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.3 | 0.9 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.3 | 153.6 | GO:0005525 | GTP binding(GO:0005525) |
| 0.3 | 7.8 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.3 | 8.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 5.1 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.3 | 6.9 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.3 | 1.6 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.3 | 1.0 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.2 | 10.3 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.2 | 14.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 2.0 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.2 | 5.6 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.2 | 1.4 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.2 | 8.3 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.2 | 7.7 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.2 | 4.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.2 | 4.7 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.2 | 1.7 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.2 | 10.0 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.2 | 3.0 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.2 | 2.8 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
| 0.2 | 2.8 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.2 | 1.8 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.2 | 2.1 | GO:0019871 | potassium channel inhibitor activity(GO:0019870) sodium channel inhibitor activity(GO:0019871) |
| 0.2 | 19.9 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.2 | 2.5 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 1.4 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 1.1 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 2.6 | GO:0015929 | hexosaminidase activity(GO:0015929) |
| 0.1 | 5.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 1.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 3.1 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.1 | 0.9 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 9.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 21.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 1.2 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 0.8 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.1 | 1.7 | GO:0017136 | NAD-dependent histone deacetylase activity(GO:0017136) |
| 0.1 | 12.0 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.1 | 18.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 0.3 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.1 | 1.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 18.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 0.3 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.1 | 2.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 1.6 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.1 | 4.8 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.1 | 6.9 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.1 | 49.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 5.7 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 1.3 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.0 | 1.2 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 5.7 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 2.3 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.9 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 1.0 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 20.0 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 17.1 | GO:0004857 | enzyme inhibitor activity(GO:0004857) |
| 0.0 | 0.2 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.0 | 1.1 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 1.1 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 2.3 | GO:0051287 | NAD binding(GO:0051287) |
| 0.0 | 0.3 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 3.0 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 0.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 1.1 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.0 | 0.9 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 1.0 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.3 | GO:0034483 | heparan sulfate sulfotransferase activity(GO:0034483) |
| 0.0 | 1.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.1 | GO:0044594 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594) |
| 0.0 | 0.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 92.6 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 1.0 | 51.9 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.7 | 6.6 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.4 | 28.6 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.4 | 3.8 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.4 | 5.7 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.3 | 19.2 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.2 | 4.6 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 5.6 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.2 | 14.4 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.1 | 1.5 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 4.0 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.1 | 30.7 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.1 | 5.8 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.1 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 6.0 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 3.9 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 2.1 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 1.8 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 4.9 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 1.6 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.8 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 2.1 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 1.0 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.8 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.3 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 41.5 | REACTOME_KINESINS | Genes involved in Kinesins |
| 1.1 | 28.6 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 1.0 | 22.6 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 9.0 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.4 | 25.4 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.4 | 34.3 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.3 | 3.8 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.3 | 7.1 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.3 | 16.8 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.3 | 9.7 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 0.4 | REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway |
| 0.2 | 3.7 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.2 | 4.5 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.1 | 4.8 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.1 | 4.8 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 1.5 | REACTOME_REGULATION_OF_INSULIN_SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.1 | 2.1 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 5.3 | REACTOME_IRON_UPTAKE_AND_TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 2.0 | REACTOME_MICRORNA_MIRNA_BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 0.9 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 2.8 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 1.2 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 4.8 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 5.4 | REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.1 | 1.9 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 0.1 | REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK | Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK |
| 0.1 | 1.0 | REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.1 | 1.5 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 2.2 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 2.5 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.1 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 1.2 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 1.8 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 2.2 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 2.9 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS | Genes involved in Synthesis of bile acids and bile salts |
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