Motif ID: RHOXF1

Z-value: 0.939


Transcription factors associated with RHOXF1:

Gene SymbolEntrez IDGene Name
RHOXF1 ENSG00000101883.4 RHOXF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RHOXF1hg19_v2_chrX_-_119249819_1192498470.087.2e-01Click!


Activity profile for motif RHOXF1.

activity profile for motif RHOXF1


Sorted Z-values histogram for motif RHOXF1

Sorted Z-values for motif RHOXF1



Network of associatons between targets according to the STRING database.



First level regulatory network of RHOXF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_54764346 4.500 ENST00000297313.3
ENST00000344277.6
 RGS20

regulator of G-protein signaling 20

chr12_+_8975061 3.189 ENST00000299698.7
 A2ML1
alpha-2-macroglobulin-like 1
chr6_+_151646800 3.015 ENST00000354675.6
 AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_7654057 2.794 ENST00000537121.1
 ADCY2
adenylate cyclase 2 (brain)
chr22_+_31488433 2.720 ENST00000455608.1
 SMTN
smoothelin
chrX_+_135251783 2.594 ENST00000394153.2
 FHL1
four and a half LIM domains 1
chr17_-_38859996 2.566 ENST00000264651.2
 KRT24
keratin 24
chr15_-_90039805 2.344 ENST00000544600.1
ENST00000268122.4
 RHCG

Rh family, C glycoprotein

chr6_+_151561506 2.340 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chr8_-_125577940 2.247 ENST00000519168.1
ENST00000395508.2
 MTSS1

metastasis suppressor 1

chr16_-_30122717 2.183 ENST00000566613.1
 GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr4_+_69313145 2.182 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chrX_+_135251835 2.161 ENST00000456445.1
 FHL1
four and a half LIM domains 1
chr6_+_151561085 1.977 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr6_+_47666275 1.750 ENST00000327753.3
ENST00000283303.2
 GPR115

G protein-coupled receptor 115

chr1_-_153113927 1.746 ENST00000368752.4
 SPRR2B
small proline-rich protein 2B
chr19_+_10397621 1.630 ENST00000380770.3
 ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397648 1.602 ENST00000340992.4
ENST00000393717.2
 ICAM4

intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

chr5_-_39219705 1.580 ENST00000351578.6
 FYB
FYN binding protein
chrX_+_99899180 1.580 ENST00000373004.3
 SRPX2
sushi-repeat containing protein, X-linked 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 432 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.3 GO:0070268 cornification(GO:0070268)
0.1 6.6 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.4 5.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.5 3.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.5 3.0 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 2.8 GO:0006936 muscle contraction(GO:0006936)
0.2 2.7 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 2.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 2.7 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 2.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 2.4 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.8 2.3 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.4 2.2 GO:0030035 microspike assembly(GO:0030035)
0.1 2.2 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.3 2.1 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.2 2.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.2 2.1 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 2.1 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.4 2.0 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.5 1.9 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.3 GO:0005925 focal adhesion(GO:0005925)
0.2 10.8 GO:0001533 cornified envelope(GO:0001533)
0.0 6.3 GO:0005882 intermediate filament(GO:0005882)
0.3 4.1 GO:0030478 actin cap(GO:0030478)
0.6 3.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 3.2 GO:0005604 basement membrane(GO:0005604)
0.2 3.1 GO:0008091 spectrin(GO:0008091)
0.1 3.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 2.5 GO:0001726 ruffle(GO:0001726)
0.1 2.3 GO:0042627 chylomicron(GO:0042627)
0.0 2.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.1 GO:0031674 I band(GO:0031674)
0.2 2.0 GO:0070552 BRISC complex(GO:0070552)
0.0 1.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.5 1.5 GO:0005588 collagen type V trimer(GO:0005588)
0.4 1.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.5 GO:0005610 laminin-5 complex(GO:0005610)
0.1 1.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 260 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 7.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 6.2 GO:0044325 ion channel binding(GO:0044325)
0.1 4.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 4.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 4.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 3.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.3 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 3.2 GO:0030506 ankyrin binding(GO:0030506)
0.5 3.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 2.5 GO:0017124 SH3 domain binding(GO:0017124)
0.2 2.4 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 2.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.3 2.1 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 2.1 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.2 2.1 GO:0042731 PH domain binding(GO:0042731)
0.1 2.1 GO:0003785 actin monomer binding(GO:0003785)
0.4 2.0 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.8 GO:0008199 ferric iron binding(GO:0008199)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 6.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 4.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 3.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 3.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 2.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.6 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.6 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.4 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.4 PID_BCR_5PATHWAY BCR signaling pathway
0.1 1.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.1 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 1.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 5.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 5.2 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 4.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 2.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 2.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 2.4 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 2.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.2 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.1 1.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.5 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.4 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.4 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 1.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.3 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 1.2 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis