Motif ID: RORC

Z-value: 0.389


Transcription factors associated with RORC:

Gene SymbolEntrez IDGene Name
RORC ENSG00000143365.12 RORC

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151798546_1517985900.321.2e-01Click!


Activity profile for motif RORC.

activity profile for motif RORC


Sorted Z-values histogram for motif RORC

Sorted Z-values for motif RORC



Network of associatons between targets according to the STRING database.



First level regulatory network of RORC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_4671352 0.577 ENST00000542744.1
 DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr12_+_7167980 0.405 ENST00000360817.5
ENST00000402681.3
 C1S

complement component 1, s subcomponent

chr8_+_71485681 0.384 ENST00000391684.1
 AC120194.1
AC120194.1
chr17_-_46623441 0.336 ENST00000330070.4
 HOXB2
homeobox B2
chr12_+_93963590 0.250 ENST00000340600.2
 SOCS2
suppressor of cytokine signaling 2
chr19_+_38924316 0.249 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
 RYR1


ryanodine receptor 1 (skeletal)


chr12_+_93964158 0.246 ENST00000549206.1
 SOCS2
suppressor of cytokine signaling 2
chrX_-_102531717 0.240 ENST00000372680.1
 TCEAL5
transcription elongation factor A (SII)-like 5
chr1_+_104198377 0.238 ENST00000370083.4
 AMY1A
amylase, alpha 1A (salivary)
chr3_-_45957088 0.223 ENST00000539217.1
 LZTFL1
leucine zipper transcription factor-like 1
chr3_-_45957534 0.186 ENST00000536047.1
 LZTFL1
leucine zipper transcription factor-like 1
chr19_-_49140609 0.178 ENST00000601104.1
 DBP
D site of albumin promoter (albumin D-box) binding protein
chr19_-_10450287 0.161 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
 ICAM3



intercellular adhesion molecule 3



chr16_-_1821496 0.157 ENST00000564628.1
ENST00000563498.1
 NME3

NME/NM23 nucleoside diphosphate kinase 3

chrX_-_43832711 0.146 ENST00000378062.5
 NDP
Norrie disease (pseudoglioma)
chr9_-_110251836 0.138 ENST00000374672.4
 KLF4
Kruppel-like factor 4 (gut)
chr19_-_49140692 0.132 ENST00000222122.5
 DBP
D site of albumin promoter (albumin D-box) binding protein
chr3_+_160559931 0.125 ENST00000464260.1
ENST00000295839.9
 PPM1L

protein phosphatase, Mg2+/Mn2+ dependent, 1L

chr20_-_23433494 0.121 ENST00000377007.3
 CST11
cystatin 11
chr10_-_21435488 0.121 ENST00000534331.1
ENST00000529198.1
ENST00000377118.4
 C10orf113


chromosome 10 open reading frame 113


chr10_-_121296045 0.120 ENST00000392865.1
 RGS10
regulator of G-protein signaling 10
chr7_-_128415844 0.120 ENST00000249389.2
 OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr14_-_23451845 0.116 ENST00000262713.2
 AJUBA
ajuba LIM protein
chr6_-_46922659 0.111 ENST00000265417.7
 GPR116
G protein-coupled receptor 116
chr12_+_56414795 0.105 ENST00000431367.2
 IKZF4
IKAROS family zinc finger 4 (Eos)
chr20_+_37209820 0.103 ENST00000537425.1
ENST00000373348.3
ENST00000416116.1
 ADIG


adipogenin


chr1_-_240906911 0.096 ENST00000431139.2
 RP11-80B9.4
RP11-80B9.4
chr12_-_54652060 0.088 ENST00000552562.1
 CBX5
chromobox homolog 5
chr7_+_112063192 0.086 ENST00000005558.4
 IFRD1
interferon-related developmental regulator 1
chr19_+_1269324 0.078 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
 CIRBP










cold inducible RNA binding protein










chr7_+_20687017 0.077 ENST00000258738.6
 ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr16_-_69385681 0.072 ENST00000288025.3
 TMED6
transmembrane emp24 protein transport domain containing 6
chr12_-_39734783 0.071 ENST00000552961.1
 KIF21A
kinesin family member 21A
chr20_-_33732952 0.070 ENST00000541621.1
 EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr3_-_65583561 0.069 ENST00000460329.2
 MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr1_+_26869597 0.068 ENST00000530003.1
 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr7_-_141541221 0.068 ENST00000350549.3
ENST00000438520.1
 PRSS37

protease, serine, 37

chr2_+_148778570 0.066 ENST00000407073.1
 MBD5
methyl-CpG binding domain protein 5
chr7_-_43965937 0.064 ENST00000455877.1
ENST00000223341.7
ENST00000447717.3
ENST00000426198.1
 URGCP



upregulator of cell proliferation



chr4_+_85504075 0.056 ENST00000295887.5
 CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr1_-_145826450 0.051 ENST00000462900.2
 GPR89A
G protein-coupled receptor 89A
chr1_-_153522562 0.046 ENST00000368714.1
 S100A4
S100 calcium binding protein A4
chr6_+_43738444 0.045 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
 VEGFA








vascular endothelial growth factor A








chr14_-_23451467 0.045 ENST00000361265.4
ENST00000555074.1
 AJUBA
RP11-298I3.5
ajuba LIM protein
RP11-298I3.5
chr17_-_37764128 0.045 ENST00000302584.4
 NEUROD2
neuronal differentiation 2
chr14_+_21785693 0.042 ENST00000382933.4
ENST00000557351.1
 RPGRIP1

retinitis pigmentosa GTPase regulator interacting protein 1

chr2_+_160590469 0.041 ENST00000409591.1
 MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr8_-_95449155 0.040 ENST00000481490.2
 FSBP
fibrinogen silencer binding protein
chr1_+_114447763 0.039 ENST00000369563.3
 DCLRE1B
DNA cross-link repair 1B
chr3_+_185303962 0.038 ENST00000296257.5
 SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr1_-_217311090 0.037 ENST00000493603.1
ENST00000366940.2
 ESRRG

estrogen-related receptor gamma

chr19_-_8567478 0.035 ENST00000255612.3
 PRAM1
PML-RARA regulated adaptor molecule 1
chr1_-_62190793 0.034 ENST00000371177.2
ENST00000606498.1
 TM2D1

TM2 domain containing 1

chr11_+_65292884 0.031 ENST00000527009.1
 SCYL1
SCY1-like 1 (S. cerevisiae)
chr16_+_1832902 0.031 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
 NUBP2





nucleotide binding protein 2





chr4_+_140586922 0.029 ENST00000265498.1
ENST00000506797.1
 MGST2

microsomal glutathione S-transferase 2

chr1_-_149908710 0.029 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
 MTMR11


myotubularin related protein 11


chr19_+_12780512 0.029 ENST00000242796.4
 WDR83
WD repeat domain 83
chr1_-_185286461 0.027 ENST00000367498.3
 IVNS1ABP
influenza virus NS1A binding protein
chr2_+_119699864 0.026 ENST00000541757.1
ENST00000412481.1
 MARCO

macrophage receptor with collagenous structure

chr16_+_24266874 0.026 ENST00000005284.3
 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr6_-_111927062 0.025 ENST00000359831.4
 TRAF3IP2
TRAF3 interacting protein 2
chr18_-_23671139 0.025 ENST00000579061.1
ENST00000542420.2
 SS18

synovial sarcoma translocation, chromosome 18

chr2_-_148778323 0.022 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
 ORC4



origin recognition complex, subunit 4



chr17_-_48785216 0.021 ENST00000285243.6
 ANKRD40
ankyrin repeat domain 40
chr13_+_109248500 0.019 ENST00000356711.2
 MYO16
myosin XVI
chr2_+_119699742 0.014 ENST00000327097.4
 MARCO
macrophage receptor with collagenous structure
chr6_+_44094627 0.014 ENST00000259746.9
 TMEM63B
transmembrane protein 63B
chr10_-_103578162 0.012 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
 MGEA5


meningioma expressed antigen 5 (hyaluronidase)


chr10_-_105845674 0.010 ENST00000353479.5
ENST00000369733.3
 COL17A1

collagen, type XVII, alpha 1

chr16_+_30937213 0.007 ENST00000427128.1
 FBXL19
F-box and leucine-rich repeat protein 19
chr7_+_20686946 0.005 ENST00000443026.2
ENST00000406935.1
 ABCB5

ATP-binding cassette, sub-family B (MDR/TAP), member 5

chr2_+_162016827 0.004 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
 TANK


TRAF family member-associated NFKB activator


chr16_+_16326352 0.004 ENST00000399336.4
ENST00000263012.6
ENST00000538468.1
 NOMO3


NODAL modulator 3


chr5_+_177557997 0.003 ENST00000313386.4
ENST00000515098.1
ENST00000542098.1
ENST00000502814.1
ENST00000507457.1
ENST00000508647.1
 RMND5B





required for meiotic nuclear division 5 homolog B (S. cerevisiae)





chr1_+_205197304 0.002 ENST00000358024.3
 TMCC2
transmembrane and coiled-coil domain family 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.3 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.1 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.0 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0007518 myoblast fate determination(GO:0007518)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.2 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.0 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.0 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1990425 ryanodine receptor complex(GO:1990425)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.2 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.2 GO:0016160 amylase activity(GO:0016160)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.5 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling