Motif ID: RREB1

Z-value: 1.249


Transcription factors associated with RREB1:

Gene SymbolEntrez IDGene Name
RREB1 ENSG00000124782.15 RREB1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RREB1hg19_v2_chr6_+_7107830_71079930.368.0e-02Click!


Activity profile for motif RREB1.

activity profile for motif RREB1


Sorted Z-values histogram for motif RREB1

Sorted Z-values for motif RREB1



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51471362 5.802 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr19_-_51471381 5.696 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51456198 4.240 ENST00000594846.1
 KLK5
kallikrein-related peptidase 5
chr19_-_51456344 4.212 ENST00000336334.3
ENST00000593428.1
 KLK5

kallikrein-related peptidase 5

chr19_-_51456321 4.204 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5
chr6_+_151646800 3.367 ENST00000354675.6
 AKAP12
A kinase (PRKA) anchor protein 12
chr12_+_96588279 3.116 ENST00000552142.1
 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr18_-_21242774 3.112 ENST00000322980.9
 ANKRD29
ankyrin repeat domain 29
chr4_+_75230853 2.656 ENST00000244869.2
 EREG
epiregulin
chr18_-_21242833 2.358 ENST00000586087.1
ENST00000592179.1
 ANKRD29

ankyrin repeat domain 29

chr19_-_19051927 2.246 ENST00000600077.1
 HOMER3
homer homolog 3 (Drosophila)
chr2_+_234104079 2.208 ENST00000417661.1
 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr16_-_4588762 2.193 ENST00000562334.1
ENST00000562579.1
ENST00000567695.1
ENST00000563507.1
 CDIP1



cell death-inducing p53 target 1



chr16_-_4588822 2.059 ENST00000564828.1
 CDIP1
cell death-inducing p53 target 1
chr19_-_19051993 1.999 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
 HOMER3



homer homolog 3 (Drosophila)



chr5_+_150591678 1.864 ENST00000523466.1
 GM2A
GM2 ganglioside activator
chr1_-_17307173 1.775 ENST00000438542.1
ENST00000375535.3
 MFAP2

microfibrillar-associated protein 2

chr16_+_447209 1.753 ENST00000382940.4
ENST00000219479.2
 NME4

NME/NM23 nucleoside diphosphate kinase 4

chr16_+_447226 1.748 ENST00000433358.1
 NME4
NME/NM23 nucleoside diphosphate kinase 4
chr16_+_58533951 1.720 ENST00000566192.1
ENST00000565088.1
ENST00000568640.1
ENST00000563978.1
ENST00000569923.1
ENST00000356752.4
ENST00000563799.1
ENST00000562999.1
ENST00000570248.1
ENST00000562731.1
ENST00000568424.1
 NDRG4










NDRG family member 4











Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 12.7 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.5 11.5 GO:0016540 protein autoprocessing(GO:0016540)
0.1 5.5 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.3 4.5 GO:0006183 GTP biosynthetic process(GO:0006183)
0.2 4.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.2 3.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 3.2 GO:0031424 keratinization(GO:0031424)
0.3 2.8 GO:0070141 response to UV-A(GO:0070141)
0.9 2.7 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.7 2.2 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.3 2.1 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 2.1 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.2 1.9 GO:0006689 ganglioside catabolic process(GO:0006689)
0.2 1.8 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 1.7 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 1.7 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.2 1.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.5 1.5 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076)
0.1 1.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 1.5 GO:0043320 natural killer cell degranulation(GO:0043320)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.7 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 10.7 GO:0030141 secretory granule(GO:0030141)
0.0 6.1 GO:0005882 intermediate filament(GO:0005882)
0.7 5.8 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.0 4.2 GO:0045178 basal part of cell(GO:0045178)
0.0 3.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 2.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 2.2 GO:0070876 SOSS complex(GO:0070876)
0.5 1.9 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 1.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 1.5 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 1.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 1.4 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.4 GO:0030673 axolemma(GO:0030673)
0.4 1.3 GO:0055028 cortical microtubule(GO:0055028)
0.1 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.3 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 4.2 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
1.2 3.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.4 3.5 GO:1901612 cardiolipin binding(GO:1901612)
0.2 3.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.4 2.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2 2.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 2.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.9 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 1.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 1.7 GO:1990254 keratin filament binding(GO:1990254)
0.1 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.5 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.4 GO:0030507 spectrin binding(GO:0030507)
0.0 1.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 1.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 1.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 4.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 3.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 2.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 0.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.8 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.8 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.8 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.7 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.6 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 3.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.3 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.3 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.3 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.1 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.0 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.0 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 1.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.9 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease