Motif ID: RUNX3_BCL11A

Z-value: 0.818

Transcription factors associated with RUNX3_BCL11A:

Gene SymbolEntrez IDGene Name
BCL11A ENSG00000119866.16 BCL11A
RUNX3 ENSG00000020633.14 RUNX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BCL11Ahg19_v2_chr2_-_60780607_60780634-0.471.9e-02Click!
RUNX3hg19_v2_chr1_-_25256368_252564760.443.2e-02Click!


Activity profile for motif RUNX3_BCL11A.

activity profile for motif RUNX3_BCL11A


Sorted Z-values histogram for motif RUNX3_BCL11A

Sorted Z-values for motif RUNX3_BCL11A



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX3_BCL11A

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_17272608 2.488 ENST00000421459.2
 VIM
vimentin
chr10_+_17270214 2.006 ENST00000544301.1
 VIM
vimentin
chr11_-_58345569 1.921 ENST00000528954.1
ENST00000528489.1
 LPXN

leupaxin

chr22_+_31488433 1.850 ENST00000455608.1
 SMTN
smoothelin
chr5_-_39270725 1.713 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
 FYB


FYN binding protein


chrX_-_106960285 1.573 ENST00000503515.1
ENST00000372397.2
 TSC22D3

TSC22 domain family, member 3

chr1_+_152486950 1.212 ENST00000368790.3
 CRCT1
cysteine-rich C-terminal 1
chr1_+_45205498 1.194 ENST00000372218.4
 KIF2C
kinesin family member 2C
chr1_+_45205478 1.158 ENST00000452259.1
ENST00000372224.4
 KIF2C

kinesin family member 2C

chr4_+_88896819 1.068 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
 SPP1



secreted phosphoprotein 1



chr5_-_39203093 1.059 ENST00000515010.1
 FYB
FYN binding protein
chr2_+_33359687 1.047 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
 LTBP1


latent transforming growth factor beta binding protein 1


chr2_+_33359646 1.000 ENST00000390003.4
ENST00000418533.2
 LTBP1

latent transforming growth factor beta binding protein 1

chr1_-_94147385 0.975 ENST00000260502.6
 BCAR3
breast cancer anti-estrogen resistance 3
chr6_+_86159821 0.971 ENST00000369651.3
 NT5E
5'-nucleotidase, ecto (CD73)
chr6_+_45296048 0.953 ENST00000465038.2
ENST00000352853.5
ENST00000541979.1
ENST00000371438.1
 RUNX2



runt-related transcription factor 2



chr22_+_40297079 0.949 ENST00000344138.4
ENST00000543252.1
 GRAP2

GRB2-related adaptor protein 2

chr10_+_5566916 0.944 ENST00000315238.1
 CALML3
calmodulin-like 3
chr22_+_40297105 0.929 ENST00000540310.1
 GRAP2
GRB2-related adaptor protein 2
chr14_+_85996471 0.880 ENST00000330753.4
 FLRT2
fibronectin leucine rich transmembrane protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.5 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 2.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 2.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 2.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 2.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.5 2.1 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.2 2.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.2 1.9 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2 1.6 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.4 1.5 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.3 1.3 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.2 1.2 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 1.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.4 1.1 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.2 1.0 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.1 1.0 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.3 0.8 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0005882 intermediate filament(GO:0005882)
0.0 3.4 GO:0002102 podosome(GO:0002102)
0.0 2.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.4 2.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 1.9 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 1.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 0.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.6 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.6 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.5 GO:1990254 keratin filament binding(GO:1990254)
0.0 2.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 2.4 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 2.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.3 2.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.4 2.0 GO:0050436 microfibril binding(GO:0050436)
0.1 1.8 GO:0045499 chemorepellent activity(GO:0045499)
0.2 1.6 GO:0043426 MRF binding(GO:0043426)
0.1 1.5 GO:0043422 protein kinase B binding(GO:0043422)
0.0 1.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.4 1.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 1.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.0 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 1.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 0.8 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.8 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.8 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 3.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.6 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 2.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.2 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.1 1.9 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.9 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.6 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 2.4 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.7 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.9 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 0.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.7 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling