Motif ID: RXRA_NR2F6_NR2C2

Z-value: 0.658

Transcription factors associated with RXRA_NR2F6_NR2C2:

Gene SymbolEntrez IDGene Name
NR2C2 ENSG00000177463.11 NR2C2
NR2F6 ENSG00000160113.5 NR2F6
RXRA ENSG00000186350.8 RXRA

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RXRAhg19_v2_chr9_+_137218362_137218426,
hg19_v2_chr9_+_137298396_137298431		-0.203.5e-01Click!
NR2F6hg19_v2_chr19_-_17356697_17356762-0.106.5e-01Click!
NR2C2hg19_v2_chr3_+_15045419_150454330.077.5e-01Click!


Activity profile for motif RXRA_NR2F6_NR2C2.

activity profile for motif RXRA_NR2F6_NR2C2


Sorted Z-values histogram for motif RXRA_NR2F6_NR2C2

Sorted Z-values for motif RXRA_NR2F6_NR2C2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRA_NR2F6_NR2C2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_681114 0.716 ENST00000503156.1
 MFSD7
major facilitator superfamily domain containing 7
chr19_-_48867291 0.546 ENST00000435956.3
 TMEM143
transmembrane protein 143
chr11_+_66624527 0.511 ENST00000393952.3
 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr9_+_126773880 0.506 ENST00000373615.4
 LHX2
LIM homeobox 2
chr19_-_48867171 0.485 ENST00000377431.2
ENST00000436660.2
ENST00000541566.1
 TMEM143


transmembrane protein 143


chr1_+_61548374 0.463 ENST00000485903.2
ENST00000371185.2
ENST00000371184.2
 NFIA


nuclear factor I/A


chr4_+_30721968 0.455 ENST00000361762.2
 PCDH7
protocadherin 7
chr17_+_37821593 0.440 ENST00000578283.1
 TCAP
titin-cap
chrX_-_108868390 0.415 ENST00000372101.2
 KCNE1L
KCNE1-like
chr5_-_42811986 0.401 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
 SEPP1


selenoprotein P, plasma, 1


chr19_+_45394477 0.392 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
 TOMM40




translocase of outer mitochondrial membrane 40 homolog (yeast)




chr7_-_75452673 0.385 ENST00000416943.1
 CCL24
chemokine (C-C motif) ligand 24
chr2_+_219433281 0.384 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
 RQCD1


RCD1 required for cell differentiation1 homolog (S. pombe)


chr3_-_49314640 0.374 ENST00000436325.1
 C3orf62
chromosome 3 open reading frame 62
chr9_+_17579084 0.374 ENST00000380607.4
 SH3GL2
SH3-domain GRB2-like 2
chr6_+_143999072 0.373 ENST00000440869.2
ENST00000367582.3
ENST00000451827.2
 PHACTR2


phosphatase and actin regulator 2


chr5_-_42812143 0.372 ENST00000514985.1
 SEPP1
selenoprotein P, plasma, 1
chr5_+_156712372 0.351 ENST00000541131.1
 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr16_-_4401284 0.348 ENST00000318059.3
 PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr1_-_43855444 0.336 ENST00000372455.4
 MED8
mediator complex subunit 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:0072189 ureter development(GO:0072189)
0.0 1.0 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 0.9 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.0 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 0.8 GO:0015692 lead ion transport(GO:0015692)
0.0 0.6 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.2 0.5 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
0.2 0.5 GO:2000583 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.5 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.4 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.4 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.4 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.4 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.4 GO:0014877 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.4 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.4 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.4 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.4 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.8 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.1 0.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.5 GO:0045240 dihydrolipoyl dehydrogenase complex(GO:0045240)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.5 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.5 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.4 GO:0071749 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.1 0.4 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.3 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.2 GO:0044393 microspike(GO:0044393)
0.1 0.2 GO:0031251 PAN complex(GO:0031251)
0.1 0.2 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0 0.2 GO:0036398 TCR signalosome(GO:0036398)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 0.8 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.2 0.8 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 0.5 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.2 0.5 GO:0004730 pseudouridylate synthase activity(GO:0004730)
0.1 0.5 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.5 GO:0001848 complement binding(GO:0001848)
0.1 0.4 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 0.4 GO:0051373 FATZ binding(GO:0051373)
0.0 0.4 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.4 GO:0015288 porin activity(GO:0015288)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.1 0.3 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.3 GO:0001855 complement component C4b binding(GO:0001855)
0.1 0.3 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.6 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen