Motif ID: RXRG

Z-value: 1.642


Transcription factors associated with RXRG:

Gene SymbolEntrez IDGene Name
RXRG ENSG00000143171.8 RXRG

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RXRGhg19_v2_chr1_-_165414414_165414433-0.154.8e-01Click!


Activity profile for motif RXRG.

activity profile for motif RXRG


Sorted Z-values histogram for motif RXRG

Sorted Z-values for motif RXRG



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51504852 5.096 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
 KLK8



kallikrein-related peptidase 8



chr10_+_88718397 4.920 ENST00000372017.3
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr10_+_88718314 4.530 ENST00000348795.4
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr12_-_58131931 4.430 ENST00000547588.1
 AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr2_+_234104079 4.390 ENST00000417661.1
 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr18_-_21242774 3.736 ENST00000322980.9
 ANKRD29
ankyrin repeat domain 29
chr12_-_57634475 3.544 ENST00000393825.1
 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr1_-_154946825 3.531 ENST00000368453.4
ENST00000368450.1
ENST00000366442.2
 SHC1


SHC (Src homology 2 domain containing) transforming protein 1


chr3_-_50340996 3.427 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
 HYAL1





hyaluronoglucosaminidase 1





chr17_+_39969183 2.989 ENST00000321562.4
 FKBP10
FK506 binding protein 10, 65 kDa
chr1_-_153521597 2.964 ENST00000368712.1
 S100A3
S100 calcium binding protein A3
chr18_-_21242833 2.963 ENST00000586087.1
ENST00000592179.1
 ANKRD29

ankyrin repeat domain 29

chr7_+_2671663 2.923 ENST00000407643.1
 TTYH3
tweety family member 3
chr16_-_85784557 2.888 ENST00000602675.1
 C16orf74
chromosome 16 open reading frame 74
chr5_+_150591678 2.879 ENST00000523466.1
 GM2A
GM2 ganglioside activator
chr22_+_31489344 2.834 ENST00000404574.1
 SMTN
smoothelin
chr16_-_85784634 2.693 ENST00000284245.4
ENST00000602914.1
 C16orf74

chromosome 16 open reading frame 74

chr6_+_43737939 2.690 ENST00000372067.3
 VEGFA
vascular endothelial growth factor A
chr17_+_7211280 2.591 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
 EIF5A


eukaryotic translation initiation factor 5A


chr1_-_6479963 2.589 ENST00000377836.4
ENST00000487437.1
ENST00000489730.1
ENST00000377834.4
 HES2



hes family bHLH transcription factor 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 311 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.5 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
2.7 8.1 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
1.0 7.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 6.0 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.3 5.4 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.6 5.1 GO:0031642 negative regulation of myelination(GO:0031642)
1.5 4.4 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.5 4.4 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.0 4.4 GO:0031424 keratinization(GO:0031424)
0.4 4.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
1.4 4.1 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
1.4 4.1 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.8 4.0 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 4.0 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.2 3.9 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.9 3.4 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.4 3.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.2 3.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.2 3.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 3.2 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.0 GO:0005925 focal adhesion(GO:0005925)
0.0 13.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 7.7 GO:0005819 spindle(GO:0005819)
0.6 7.3 GO:0005642 annulate lamellae(GO:0005642)
0.1 5.9 GO:0045095 keratin filament(GO:0045095)
1.1 5.5 GO:0009368 endopeptidase Clp complex(GO:0009368)
0.0 5.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 5.0 GO:0031985 Golgi cisterna(GO:0031985)
0.1 4.7 GO:0001772 immunological synapse(GO:0001772)
0.0 4.7 GO:0043202 lysosomal lumen(GO:0043202)
0.0 4.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 4.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 4.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 4.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.9 GO:0031901 early endosome membrane(GO:0031901)
0.6 3.5 GO:0070435 Shc-EGFR complex(GO:0070435)
0.2 3.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 3.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 3.2 GO:0030122 AP-2 adaptor complex(GO:0030122) endolysosome membrane(GO:0036020)
0.1 3.1 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.4 GO:0005525 GTP binding(GO:0005525)
0.0 9.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 9.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 6.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 5.4 GO:0002020 protease binding(GO:0002020)
0.1 5.2 GO:0070412 R-SMAD binding(GO:0070412)
1.2 4.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 4.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
1.5 4.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.7 4.4 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 4.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.3 GO:0005096 GTPase activator activity(GO:0005096)
0.4 4.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
1.4 4.1 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.7 4.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 3.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 3.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 3.6 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.5 3.5 GO:0048408 epidermal growth factor binding(GO:0048408)
0.5 3.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 11.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 4.3 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 4.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.2 4.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 3.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 3.1 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 3.1 PID_E2F_PATHWAY E2F transcription factor network
0.1 2.7 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 2.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 2.5 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 2.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 2.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.2 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.3 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 8.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 7.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 5.8 REACTOME_SHC_MEDIATED_SIGNALLING Genes involved in SHC-mediated signalling
0.2 5.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 4.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.3 4.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 4.3 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.2 4.1 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 4.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.8 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.0 3.7 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 3.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.2 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.2 3.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 2.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi