Motif ID: SCRT1_SCRT2

Z-value: 0.898

Transcription factors associated with SCRT1_SCRT2:

Gene SymbolEntrez IDGene Name
SCRT1 ENSG00000170616.9 SCRT1
SCRT2 ENSG00000215397.3 SCRT2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SCRT1hg19_v2_chr8_-_145559943_145559943-0.213.3e-01Click!


Activity profile for motif SCRT1_SCRT2.

activity profile for motif SCRT1_SCRT2


Sorted Z-values histogram for motif SCRT1_SCRT2

Sorted Z-values for motif SCRT1_SCRT2



Network of associatons between targets according to the STRING database.



First level regulatory network of SCRT1_SCRT2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_149363662 5.966 ENST00000355292.3
ENST00000358102.3
 NR3C2

nuclear receptor subfamily 3, group C, member 2

chr4_+_165675197 5.856 ENST00000515485.1
 RP11-294O2.2
RP11-294O2.2
chr4_+_165675269 4.422 ENST00000507311.1
 RP11-294O2.2
RP11-294O2.2
chr19_-_7990991 4.337 ENST00000318978.4
 CTXN1
cortexin 1
chr3_-_167371740 3.802 ENST00000466760.1
ENST00000479765.1
 WDR49

WD repeat domain 49

chr1_-_104238912 3.008 ENST00000330330.5
 AMY1B
amylase, alpha 1B (salivary)
chr1_-_104239076 2.973 ENST00000370080.3
 AMY1B
amylase, alpha 1B (salivary)
chr13_+_43355683 2.924 ENST00000537894.1
 FAM216B
family with sequence similarity 216, member B
chr2_+_10861775 2.777 ENST00000272238.4
ENST00000381661.3
 ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr17_+_53343577 2.608 ENST00000573945.1
 HLF
hepatic leukemia factor
chr5_-_35938674 2.594 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr3_+_181429704 2.345 ENST00000431565.2
ENST00000325404.1
 SOX2

SRY (sex determining region Y)-box 2

chr8_-_133772794 2.305 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
 TMEM71




transmembrane protein 71




chr7_-_122526499 2.220 ENST00000412584.2
 CADPS2
Ca++-dependent secretion activator 2
chr11_-_26593677 1.933 ENST00000527569.1
 MUC15
mucin 15, cell surface associated
chr16_+_19179549 1.905 ENST00000355377.2
ENST00000568115.1
 SYT17

synaptotagmin XVII

chr1_-_183622442 1.888 ENST00000308641.4
 APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr10_+_23216944 1.826 ENST00000298032.5
ENST00000409983.3
ENST00000409049.3
 ARMC3


armadillo repeat containing 3


chr10_+_23217006 1.825 ENST00000376528.4
ENST00000447081.1
 ARMC3

armadillo repeat containing 3

chr22_-_22090043 1.756 ENST00000403503.1
 YPEL1
yippee-like 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 4.3 GO:0016266 O-glycan processing(GO:0016266)
0.4 3.5 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 3.3 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 2.8 GO:0006527 arginine catabolic process(GO:0006527)
0.3 2.3 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 2.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 1.8 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 1.5 GO:0006670 sphingosine metabolic process(GO:0006670)
0.5 1.4 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.1 1.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 1.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 1.2 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.2 1.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 1.0 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 1.0 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.0 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.8 GO:1990253 cellular response to leucine starvation(GO:1990253)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0043235 receptor complex(GO:0043235)
0.0 3.8 GO:0005796 Golgi lumen(GO:0005796)
0.5 2.8 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 2.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 1.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.8 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.7 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.7 GO:1990393 3M complex(GO:1990393)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 3.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 2.8 GO:0016403 dimethylargininase activity(GO:0016403)
0.3 2.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 2.3 GO:0035198 miRNA binding(GO:0035198)
0.0 2.1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.4 1.5 GO:0016160 amylase activity(GO:0016160)
0.2 1.2 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 1.1 GO:0051400 BH domain binding(GO:0051400)
0.3 1.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.8 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 0.7 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.1 0.7 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 0.5 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 7.5 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 5.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.9 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.5 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.2 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors