Motif ID: SHOX2_HOXC5

Z-value: 0.590

Transcription factors associated with SHOX2_HOXC5:

Gene SymbolEntrez IDGene Name
HOXC5 ENSG00000172789.3 HOXC5
SHOX2 ENSG00000168779.15 SHOX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SHOX2hg19_v2_chr3_-_157823839_1578240780.203.4e-01Click!
HOXC5hg19_v2_chr12_+_54426637_544266370.174.4e-01Click!


Activity profile for motif SHOX2_HOXC5.

activity profile for motif SHOX2_HOXC5


Sorted Z-values histogram for motif SHOX2_HOXC5

Sorted Z-values for motif SHOX2_HOXC5



Network of associatons between targets according to the STRING database.



First level regulatory network of SHOX2_HOXC5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_6779326 1.965 ENST00000417112.1
 RP11-554I8.2
RP11-554I8.2
chr2_+_102953608 1.788 ENST00000311734.2
ENST00000409584.1
 IL1RL1

interleukin 1 receptor-like 1

chr1_-_197115818 1.626 ENST00000367409.4
ENST00000294732.7
 ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr5_+_150639360 1.530 ENST00000523004.1
 GM2A
GM2 ganglioside activator
chr12_-_10978957 1.326 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chr19_+_42212501 1.259 ENST00000398599.4
 CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr5_-_9630463 1.214 ENST00000382492.2
 TAS2R1
taste receptor, type 2, member 1
chr12_-_95510743 1.204 ENST00000551521.1
 FGD6
FYVE, RhoGEF and PH domain containing 6
chr19_+_42212526 1.158 ENST00000221992.6
ENST00000405816.1
ENST00000598976.1
ENST00000435837.2
 CEACAM5

CEA

carcinoembryonic antigen-related cell adhesion molecule 5

Uncharacterized protein

chr11_+_35201826 1.147 ENST00000531873.1
 CD44
CD44 molecule (Indian blood group)
chr12_-_48164812 1.117 ENST00000549151.1
ENST00000548919.1
 RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr12_-_8803128 1.049 ENST00000543467.1
 MFAP5
microfibrillar associated protein 5
chr11_+_55578854 1.037 ENST00000333973.2
 OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr11_-_107729887 1.007 ENST00000525815.1
 SLC35F2
solute carrier family 35, member F2
chr4_+_86525299 0.956 ENST00000512201.1
 ARHGAP24
Rho GTPase activating protein 24
chr14_+_56584414 0.946 ENST00000559044.1
 PELI2
pellino E3 ubiquitin protein ligase family member 2
chr20_+_30102231 0.941 ENST00000335574.5
ENST00000340852.5
ENST00000398174.3
ENST00000376127.3
ENST00000344042.5
 HM13




histocompatibility (minor) 13




chr2_+_68961934 0.912 ENST00000409202.3
 ARHGAP25
Rho GTPase activating protein 25
chr2_+_68961905 0.906 ENST00000295381.3
 ARHGAP25
Rho GTPase activating protein 25
chr9_-_21305312 0.899 ENST00000259555.4
 IFNA5
interferon, alpha 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 298 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 2.7 GO:0018149 peptide cross-linking(GO:0018149)
0.1 2.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 2.4 GO:0031424 keratinization(GO:0031424)
0.1 2.3 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1 2.3 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.0 2.2 GO:0046847 filopodium assembly(GO:0046847)
0.0 2.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.3 1.8 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 1.8 GO:0002377 immunoglobulin production(GO:0002377)
0.4 1.7 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.5 1.6 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 1.5 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 1.4 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.1 1.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 1.3 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 1.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.3 1.1 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1 1.1 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0001533 cornified envelope(GO:0001533)
0.0 2.6 GO:0001726 ruffle(GO:0001726)
0.1 2.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.2 1.6 GO:0036449 microtubule minus-end(GO:0036449)
0.4 1.5 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 1.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 1.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 1.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 1.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.3 0.9 GO:0005607 laminin-2 complex(GO:0005607)
0.2 0.9 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.2 0.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.9 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.8 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 209 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 2.8 GO:0005549 odorant binding(GO:0005549)
0.1 2.8 GO:0003823 antigen binding(GO:0003823)
0.1 2.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 2.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 2.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 2.1 GO:0034235 GPI anchor binding(GO:0034235)
0.2 2.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.6 1.8 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 1.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.0 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 0.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 2.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.4 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 2.4 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.8 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 1.6 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.4 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.2 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.0 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.0 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.0 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction