Motif ID: SIN3A_CHD1

Z-value: 2.030

Transcription factors associated with SIN3A_CHD1:

Gene SymbolEntrez IDGene Name
CHD1 ENSG00000153922.6 CHD1
SIN3A ENSG00000169375.11 SIN3A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SIN3Ahg19_v2_chr15_-_75748115_75748126,
hg19_v2_chr15_-_75743915_75743933		0.555.8e-03Click!
CHD1hg19_v2_chr5_-_98262240_98262240-0.029.2e-01Click!


Activity profile for motif SIN3A_CHD1.

activity profile for motif SIN3A_CHD1


Sorted Z-values histogram for motif SIN3A_CHD1

Sorted Z-values for motif SIN3A_CHD1



Network of associatons between targets according to the STRING database.



First level regulatory network of SIN3A_CHD1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_19988462 19.814 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr4_-_7044657 12.200 ENST00000310085.4
 CCDC96
coiled-coil domain containing 96
chr13_+_35516390 11.680 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
 NBEA


neurobeachin


chr19_-_7990991 11.420 ENST00000318978.4
 CTXN1
cortexin 1
chr16_-_66959429 11.234 ENST00000420652.1
ENST00000299759.6
 RRAD

Ras-related associated with diabetes

chr16_-_52580920 9.644 ENST00000219746.9
 TOX3
TOX high mobility group box family member 3
chr17_+_55333876 9.332 ENST00000284073.2
 MSI2
musashi RNA-binding protein 2
chr4_+_72052964 8.154 ENST00000264485.5
ENST00000425175.1
 SLC4A4

solute carrier family 4 (sodium bicarbonate cotransporter), member 4

chr11_-_75379612 7.354 ENST00000526740.1
 MAP6
microtubule-associated protein 6
chrX_+_16964794 7.183 ENST00000357277.3
 REPS2
RALBP1 associated Eps domain containing 2
chrX_+_16964985 7.141 ENST00000303843.7
 REPS2
RALBP1 associated Eps domain containing 2
chr11_+_61276214 5.814 ENST00000378075.2
 LRRC10B
leucine rich repeat containing 10B
chr13_-_37494365 5.811 ENST00000350148.5
 SMAD9
SMAD family member 9
chr11_-_75380165 5.780 ENST00000304771.3
 MAP6
microtubule-associated protein 6
chr1_+_41827594 5.657 ENST00000372591.1
 FOXO6
forkhead box O6
chr22_-_31741757 5.634 ENST00000215919.3
 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr5_-_180018540 5.624 ENST00000292641.3
 SCGB3A1
secretoglobin, family 3A, member 1
chr16_+_67465016 5.589 ENST00000326152.5
 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr1_-_67390474 5.539 ENST00000371023.3
ENST00000371022.3
ENST00000371026.3
ENST00000431318.1
 WDR78



WD repeat domain 78



chr7_-_131241361 5.410 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
 PODXL



podocalyxin-like




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 956 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 11.2 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
1.0 10.4 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 10.0 GO:0030449 regulation of complement activation(GO:0030449)
0.1 9.5 GO:0032418 lysosome localization(GO:0032418)
0.4 9.2 GO:0036158 outer dynein arm assembly(GO:0036158)
1.0 8.2 GO:0048105 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.8 8.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 8.2 GO:0030901 midbrain development(GO:0030901)
0.1 7.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
1.4 7.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.3 7.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.5 7.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.7 6.9 GO:0000255 allantoin metabolic process(GO:0000255)
0.8 6.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.4 6.4 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.4 6.3 GO:1903012 positive regulation of bone development(GO:1903012)
0.2 6.1 GO:0044458 motile cilium assembly(GO:0044458)
0.8 6.0 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.1 6.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.8 5.5 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 307 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.2 GO:0016605 PML body(GO:0016605)
0.1 13.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 9.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.5 8.6 GO:0005858 axonemal dynein complex(GO:0005858)
0.1 8.6 GO:0005923 bicellular tight junction(GO:0005923)
0.1 8.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4 8.2 GO:0032591 dendritic spine membrane(GO:0032591)
2.0 8.1 GO:0060187 cell pole(GO:0060187)
0.3 8.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.6 7.7 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 7.7 GO:0036064 ciliary basal body(GO:0036064)
0.2 7.3 GO:0090544 BAF-type complex(GO:0090544)
0.5 7.2 GO:0001520 outer dense fiber(GO:0001520)
0.8 6.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 6.9 GO:0071141 SMAD protein complex(GO:0071141)
0.8 6.7 GO:0044294 dendritic growth cone(GO:0044294)
1.1 6.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
1.4 5.7 GO:0097224 sperm connecting piece(GO:0097224)
0.0 5.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 5.5 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 511 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 32.2 GO:0003677 DNA binding(GO:0003677)
0.1 22.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 21.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.1 11.6 GO:0034056 estrogen response element binding(GO:0034056)
0.4 11.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 11.6 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.8 11.0 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.3 10.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 9.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.4 8.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 7.3 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 7.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 7.1 GO:0031491 nucleosome binding(GO:0031491)
0.8 7.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
1.3 6.7 GO:0031750 D3 dopamine receptor binding(GO:0031750)
1.1 6.5 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.3 6.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.6 5.8 GO:0045545 syndecan binding(GO:0045545)
1.9 5.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.5 5.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 16.0 PID_ALK2_PATHWAY ALK2 signaling events
0.1 13.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 13.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 8.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 7.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 6.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 6.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 6.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 6.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 4.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 4.3 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 3.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 3.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.5 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.2 PID_PLK1_PATHWAY PLK1 signaling events
0.2 2.9 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 2.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 2.7 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 8.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 8.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 7.6 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.2 7.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 7.1 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3 6.7 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 6.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 5.2 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.2 5.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.3 4.8 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.3 4.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 4.5 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.1 4.5 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.0 4.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 4.3 REACTOME_SIGNALING_BY_FGFR1_MUTANTS Genes involved in Signaling by FGFR1 mutants
0.1 4.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 4.0 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.2 3.9 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 3.8 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC