Motif ID: SIX1_SIX3_SIX2
Z-value: 0.501
Transcription factors associated with SIX1_SIX3_SIX2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
SIX1 | ENSG00000126778.7 | SIX1 |
SIX2 | ENSG00000170577.7 | SIX2 |
SIX3 | ENSG00000138083.3 | SIX3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
SIX3 | hg19_v2_chr2_+_45168875_45168916 | 0.27 | 2.0e-01 | Click! |
SIX1 | hg19_v2_chr14_-_61124977_61125037 | 0.08 | 7.0e-01 | Click! |
SIX2 | hg19_v2_chr2_-_45236540_45236577 | -0.05 | 8.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.8 | GO:0003331 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
0.1 | 0.6 | GO:0072299 | negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) |
0.1 | 0.9 | GO:0010587 | miRNA catabolic process(GO:0010587) |
0.1 | 0.3 | GO:0033214 | iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308) |
0.1 | 0.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
0.1 | 0.6 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
0.1 | 0.4 | GO:1904158 | axonemal central apparatus assembly(GO:1904158) |
0.1 | 0.3 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
0.1 | 0.4 | GO:0009804 | coumarin metabolic process(GO:0009804) |
0.1 | 0.8 | GO:0006108 | malate metabolic process(GO:0006108) |
0.0 | 0.5 | GO:0048023 | positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
0.0 | 0.2 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
0.0 | 0.2 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
0.0 | 0.9 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
0.0 | 0.1 | GO:0003147 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) |
0.0 | 0.3 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
0.0 | 0.1 | GO:0006425 | glutaminyl-tRNA aminoacylation(GO:0006425) |
0.0 | 0.1 | GO:0003366 | cell-matrix adhesion involved in ameboidal cell migration(GO:0003366) |
0.0 | 0.2 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
0.0 | 0.2 | GO:0016078 | tRNA catabolic process(GO:0016078) |
0.0 | 0.2 | GO:0071798 | response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799) |
0.0 | 0.2 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
0.0 | 0.2 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
0.0 | 0.0 | GO:0043449 | cellular alkene metabolic process(GO:0043449) |
0.0 | 0.3 | GO:0015747 | urate transport(GO:0015747) |
0.0 | 0.1 | GO:0007228 | positive regulation of hh target transcription factor activity(GO:0007228) |
0.0 | 0.1 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
0.0 | 0.1 | GO:0048539 | bone marrow development(GO:0048539) |
0.0 | 0.4 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
0.0 | 0.0 | GO:2001160 | regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162) |
0.0 | 0.1 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
0.0 | 0.0 | GO:2000017 | positive regulation of determination of dorsal identity(GO:2000017) |
0.0 | 0.1 | GO:2000569 | T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570) |
0.0 | 0.2 | GO:0042048 | olfactory behavior(GO:0042048) |
0.0 | 0.1 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) |
0.0 | 0.1 | GO:1903027 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027) |
0.0 | 0.0 | GO:0038193 | thromboxane A2 signaling pathway(GO:0038193) |
0.0 | 0.1 | GO:0043091 | L-arginine import(GO:0043091) arginine import(GO:0090467) |
0.0 | 0.2 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
0.0 | 0.0 | GO:0046874 | quinolinate metabolic process(GO:0046874) |
0.0 | 0.0 | GO:0019417 | sulfur oxidation(GO:0019417) |
0.0 | 0.1 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
0.0 | 0.1 | GO:0009730 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) |
0.0 | 0.2 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
0.0 | 0.0 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) |
0.0 | 0.1 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
0.0 | 0.1 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) |
0.0 | 0.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
0.0 | 0.1 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
0.0 | 0.1 | GO:0070327 | thyroid hormone transport(GO:0070327) |
0.0 | 0.1 | GO:2000852 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.4 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
0.0 | 0.3 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
0.0 | 0.1 | GO:0016939 | kinesin II complex(GO:0016939) |
0.0 | 0.1 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.0 | 0.1 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
0.0 | 0.2 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
0.0 | 0.4 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
0.0 | 0.0 | GO:0048179 | activin receptor complex(GO:0048179) |
0.0 | 0.1 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
0.0 | 0.0 | GO:0005960 | glycine cleavage complex(GO:0005960) |
0.0 | 0.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
0.0 | 0.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
0.0 | 0.1 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.8 | GO:0047961 | glycine N-acyltransferase activity(GO:0047961) |
0.1 | 0.6 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
0.1 | 0.8 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
0.1 | 0.6 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.1 | 0.9 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
0.1 | 0.2 | GO:0004958 | prostaglandin F receptor activity(GO:0004958) |
0.1 | 0.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
0.0 | 0.2 | GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) |
0.0 | 0.1 | GO:0032090 | Pyrin domain binding(GO:0032090) |
0.0 | 0.1 | GO:0004819 | glutamine-tRNA ligase activity(GO:0004819) |
0.0 | 0.1 | GO:0015616 | DNA translocase activity(GO:0015616) |
0.0 | 0.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.2 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
0.0 | 0.4 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
0.0 | 0.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
0.0 | 0.1 | GO:0051870 | methotrexate binding(GO:0051870) folic acid receptor activity(GO:0061714) |
0.0 | 0.1 | GO:0004925 | prolactin receptor activity(GO:0004925) |
0.0 | 0.3 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
0.0 | 0.1 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
0.0 | 0.2 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
0.0 | 0.3 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
0.0 | 0.1 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
0.0 | 0.1 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
0.0 | 0.0 | GO:0004961 | thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961) |
0.0 | 0.1 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
0.0 | 0.1 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
0.0 | 0.1 | GO:0004966 | galanin receptor activity(GO:0004966) |
0.0 | 0.1 | GO:0070996 | type 1 melanocortin receptor binding(GO:0070996) |
0.0 | 0.0 | GO:0004766 | spermidine synthase activity(GO:0004766) |
0.0 | 0.1 | GO:0004340 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
0.0 | 0.1 | GO:0016215 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.7 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
0.0 | 0.2 | REACTOME_PROSTANOID_LIGAND_RECEPTORS | Genes involved in Prostanoid ligand receptors |
0.0 | 0.3 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
0.0 | 0.3 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |