Motif ID: SIX1_SIX3_SIX2

Z-value: 0.501

Transcription factors associated with SIX1_SIX3_SIX2:

Gene SymbolEntrez IDGene Name
SIX1 ENSG00000126778.7 SIX1
SIX2 ENSG00000170577.7 SIX2
SIX3 ENSG00000138083.3 SIX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SIX3hg19_v2_chr2_+_45168875_451689160.272.0e-01Click!
SIX1hg19_v2_chr14_-_61124977_611250370.087.0e-01Click!
SIX2hg19_v2_chr2_-_45236540_45236577-0.058.2e-01Click!


Activity profile for motif SIX1_SIX3_SIX2.

activity profile for motif SIX1_SIX3_SIX2


Sorted Z-values histogram for motif SIX1_SIX3_SIX2

Sorted Z-values for motif SIX1_SIX3_SIX2



Network of associatons between targets according to the STRING database.



First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_58499434 0.754 ENST00000344743.3
ENST00000278400.3
 GLYAT

glycine-N-acyltransferase

chr1_-_13115578 0.733 ENST00000414205.2
 PRAMEF6
PRAME family member 6
chr1_-_13117736 0.645 ENST00000376192.5
ENST00000376182.1
 PRAMEF6

PRAME family member 6

chr1_+_13359819 0.616 ENST00000376168.1
 PRAMEF5
PRAME family member 5
chr11_-_32452357 0.597 ENST00000379079.2
ENST00000530998.1
 WT1

Wilms tumor 1

chr20_-_55100981 0.546 ENST00000243913.4
 GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr9_+_12693336 0.504 ENST00000381137.2
ENST00000388918.5
 TYRP1

tyrosinase-related protein 1

chr6_-_76203454 0.486 ENST00000237172.7
 FILIP1
filamin A interacting protein 1
chr1_+_26737253 0.464 ENST00000326279.6
 LIN28A
lin-28 homolog A (C. elegans)
chr7_+_123241908 0.453 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
 ASB15


ankyrin repeat and SOCS box containing 15


chr1_+_26737292 0.443 ENST00000254231.4
 LIN28A
lin-28 homolog A (C. elegans)
chr1_-_240906911 0.443 ENST00000431139.2
 RP11-80B9.4
RP11-80B9.4
chr19_+_41594377 0.421 ENST00000330436.3
 CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr13_-_46679185 0.415 ENST00000439329.3
 CPB2
carboxypeptidase B2 (plasma)
chrX_-_65259914 0.410 ENST00000374737.4
ENST00000455586.2
 VSIG4

V-set and immunoglobulin domain containing 4

chrX_-_65259900 0.408 ENST00000412866.2
 VSIG4
V-set and immunoglobulin domain containing 4
chr13_-_46679144 0.406 ENST00000181383.4
 CPB2
carboxypeptidase B2 (plasma)
chr1_+_241695424 0.400 ENST00000366558.3
ENST00000366559.4
 KMO

kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

chr2_-_207629997 0.386 ENST00000454776.2
 MDH1B
malate dehydrogenase 1B, NAD (soluble)
chrX_+_101470280 0.374 ENST00000395088.2
ENST00000330252.5
ENST00000333110.5
 NXF2

TCP11X1
nuclear RNA export factor 2

t-complex 11 family, X-linked 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.9 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.2 0.8 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.8 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.6 GO:0072299 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.1 0.6 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.5 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 0.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.4 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.3 GO:0033214 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.1 0.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.3 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.3 GO:0015747 urate transport(GO:0015747)
0.0 0.2 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.2 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.4 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.4 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.0 GO:0005960 glycine cleavage complex(GO:0005960)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 0.8 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.1 0.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.6 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.2 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.2 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.2 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.1 GO:0032090 Pyrin domain binding(GO:0032090)
0.0 0.1 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0051870 methotrexate binding(GO:0051870) folic acid receptor activity(GO:0061714)
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.3 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors