Motif ID: SIX4

Z-value: 0.557


Transcription factors associated with SIX4:

Gene SymbolEntrez IDGene Name
SIX4 ENSG00000100625.8 SIX4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SIX4hg19_v2_chr14_-_61190754_611908520.611.4e-03Click!


Activity profile for motif SIX4.

activity profile for motif SIX4


Sorted Z-values histogram for motif SIX4

Sorted Z-values for motif SIX4



Network of associatons between targets according to the STRING database.



First level regulatory network of SIX4

PNG image of the network

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Top targets:


Showing 1 to 20 of 107 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_207119738 3.172 ENST00000356495.4
 PIGR
polymeric immunoglobulin receptor
chr1_+_38022572 1.909 ENST00000541606.1
 DNALI1
dynein, axonemal, light intermediate chain 1
chr1_-_151778630 1.340 ENST00000368820.3
 LINGO4
leucine rich repeat and Ig domain containing 4
chr3_-_52488048 1.265 ENST00000232975.3
 TNNC1
troponin C type 1 (slow)
chr12_-_10282836 1.218 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
 CLEC7A


C-type lectin domain family 7, member A


chrY_+_22737678 0.909 ENST00000382772.3
 EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chrY_+_22737604 0.882 ENST00000361365.2
 EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr19_+_13134772 0.879 ENST00000587760.1
ENST00000585575.1
 NFIX

nuclear factor I/X (CCAAT-binding transcription factor)

chr12_+_133758115 0.845 ENST00000541009.2
ENST00000592241.1
 ZNF268

zinc finger protein 268

chr12_-_10282742 0.759 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A


C-type lectin domain family 7, member A


chr8_+_144798429 0.757 ENST00000338033.4
ENST00000395107.4
ENST00000395108.2
 MAPK15


mitogen-activated protein kinase 15


chr12_+_133757995 0.734 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
 ZNF268









zinc finger protein 268









chr12_-_10282681 0.729 ENST00000533022.1
 CLEC7A
C-type lectin domain family 7, member A
chr3_+_118866222 0.724 ENST00000490594.1
 RP11-484M3.5
Uncharacterized protein
chr16_+_640201 0.652 ENST00000563109.1
 RAB40C
RAB40C, member RAS oncogene family
chr6_-_76072719 0.648 ENST00000370020.1
 FILIP1
filamin A interacting protein 1
chr8_+_144295067 0.557 ENST00000330824.2
 GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr11_-_130184555 0.543 ENST00000525842.1
 ZBTB44
zinc finger and BTB domain containing 44
chr14_-_67981916 0.522 ENST00000357461.2
 TMEM229B
transmembrane protein 229B
chr6_+_1080164 0.498 ENST00000314040.1
 AL033381.1
Uncharacterized protein; cDNA FLJ34594 fis, clone KIDNE2009109

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 2.7 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.5 1.6 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.3 1.3 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.0 0.8 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.6 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 0.5 GO:0098582 innate vocalization behavior(GO:0098582)
0.2 0.5 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.5 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.5 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.5 GO:1903416 response to glycoside(GO:1903416)
0.1 0.4 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.4 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.3 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.2 GO:0071106 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.1 0.2 GO:0042369 vitamin D catabolic process(GO:0042369)
0.1 0.2 GO:1900369 transcription, RNA-templated(GO:0001172) negative regulation of RNA interference(GO:1900369)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.9 GO:0030286 dynein complex(GO:0030286)
0.2 1.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.4 GO:0001740 Barr body(GO:0001740)
0.0 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.2 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.0 0.2 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 2.7 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 1.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 1.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.3 GO:0031013 troponin I binding(GO:0031013)
0.0 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.6 GO:0008035 high-density lipoprotein particle binding(GO:0008035) lipase binding(GO:0035473)
0.2 0.5 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.5 GO:1990239 steroid hormone binding(GO:1990239)
0.1 0.4 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 0.2 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 0.2 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 0.2 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.2 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID_IL27_PATHWAY IL27-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.4 REACTOME_OPSINS Genes involved in Opsins
0.0 0.2 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.1 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors