Motif ID: SIX5_SMARCC2_HCFC1

Z-value: 2.005

Transcription factors associated with SIX5_SMARCC2_HCFC1:

Gene SymbolEntrez IDGene Name
HCFC1 ENSG00000172534.9 HCFC1
SIX5 ENSG00000177045.6 SIX5
SMARCC2 ENSG00000139613.7 SMARCC2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMARCC2hg19_v2_chr12_-_56583332_565833690.555.5e-03Click!
SIX5hg19_v2_chr19_-_46272106_46272115-0.242.6e-01Click!
HCFC1hg19_v2_chrX_-_153236819_153236978,
hg19_v2_chrX_-_153237258_153237295,
hg19_v2_chrX_-_153236620_153236684		0.213.3e-01Click!


Activity profile for motif SIX5_SMARCC2_HCFC1.

activity profile for motif SIX5_SMARCC2_HCFC1


Sorted Z-values histogram for motif SIX5_SMARCC2_HCFC1

Sorted Z-values for motif SIX5_SMARCC2_HCFC1



Network of associatons between targets according to the STRING database.



First level regulatory network of SIX5_SMARCC2_HCFC1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_72435709 12.027 ENST00000377197.3
ENST00000527647.1
 C9orf135

chromosome 9 open reading frame 135

chr16_+_67840986 4.793 ENST00000561639.1
ENST00000567852.1
ENST00000565148.1
ENST00000388833.3
ENST00000561654.1
ENST00000431934.2
 TSNAXIP1





translin-associated factor X interacting protein 1





chr16_+_67840668 4.610 ENST00000415766.3
 TSNAXIP1
translin-associated factor X interacting protein 1
chr17_+_7761013 4.324 ENST00000571846.1
 CYB5D1
cytochrome b5 domain containing 1
chr2_+_219135115 4.149 ENST00000248451.3
ENST00000273077.4
 PNKD

paroxysmal nonkinesigenic dyskinesia

chr19_-_55677920 4.134 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
 DNAAF3


dynein, axonemal, assembly factor 3


chr19_-_44860820 4.127 ENST00000354340.4
ENST00000337401.4
ENST00000587909.1
 ZNF112


zinc finger protein 112


chr1_+_45965725 4.014 ENST00000401061.4
 MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr19_+_44669280 4.013 ENST00000590089.1
ENST00000454662.2
 ZNF226

zinc finger protein 226

chr8_+_110346546 3.871 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
 ENY2


enhancer of yellow 2 homolog (Drosophila)


chr16_-_53737722 3.768 ENST00000569716.1
ENST00000562588.1
ENST00000562230.1
ENST00000379925.3
ENST00000563746.1
ENST00000568653.3
 RPGRIP1L





RPGRIP1-like





chr16_-_53737795 3.736 ENST00000262135.4
ENST00000564374.1
ENST00000566096.1
 RPGRIP1L


RPGRIP1-like


chr3_+_69788576 3.612 ENST00000352241.4
ENST00000448226.2
 MITF

microphthalmia-associated transcription factor

chr9_+_72435749 3.528 ENST00000480564.1
 C9orf135
chromosome 9 open reading frame 135
chr7_+_76751926 3.487 ENST00000285871.4
ENST00000431197.1
 CCDC146

coiled-coil domain containing 146

chr11_+_73358594 3.391 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
 PLEKHB1


pleckstrin homology domain containing, family B (evectins) member 1


chr14_+_77924204 3.092 ENST00000555133.1
 AHSA1
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr11_+_71791849 2.994 ENST00000423494.2
ENST00000539587.1
ENST00000538478.1
ENST00000324866.7
ENST00000439209.1
 LRTOMT




leucine rich transmembrane and O-methyltransferase domain containing




chr11_+_36616355 2.968 ENST00000532470.2
 C11orf74
chromosome 11 open reading frame 74
chr12_+_133657461 2.957 ENST00000412146.2
ENST00000544426.1
ENST00000440984.2
ENST00000319849.3
ENST00000440550.2
 ZNF140




zinc finger protein 140





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 281 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.3 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.4 7.4 GO:0021670 lateral ventricle development(GO:0021670)
0.2 6.0 GO:0044458 motile cilium assembly(GO:0044458)
0.1 6.0 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.2 5.5 GO:0016180 snRNA processing(GO:0016180)
0.1 5.5 GO:0042073 intraciliary transport(GO:0042073)
0.7 5.4 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.1 5.1 GO:0048678 response to axon injury(GO:0048678)
1.1 4.5 GO:0032053 ciliary basal body organization(GO:0032053)
0.2 4.4 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 4.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
1.4 4.1 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
1.0 4.0 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 4.0 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.3 3.9 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 3.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.4 3.7 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.2 3.7 GO:0007220 Notch receptor processing(GO:0007220)
0.0 3.6 GO:0032781 positive regulation of ATPase activity(GO:0032781)
1.2 3.5 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
1.9 9.4 GO:0005879 axonemal microtubule(GO:0005879)
0.2 6.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 6.0 GO:0005929 cilium(GO:0005929)
0.2 5.6 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 5.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.4 5.3 GO:0032039 integrator complex(GO:0032039)
0.2 4.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 4.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 3.9 GO:0000124 SAGA complex(GO:0000124)
0.3 3.7 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 3.7 GO:0015030 Cajal body(GO:0015030)
0.5 3.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 3.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 3.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.0 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 2.8 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 2.7 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.4 2.6 GO:0005797 Golgi medial cisterna(GO:0005797)
0.6 2.5 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 52.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 10.2 GO:0070888 E-box binding(GO:0070888)
1.0 9.4 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
2.9 8.6 GO:0031862 prostanoid receptor binding(GO:0031862)
0.2 5.7 GO:0001671 ATPase activator activity(GO:0001671)
0.4 5.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 4.5 GO:0035064 methylated histone binding(GO:0035064)
0.4 4.4 GO:0031419 cobalamin binding(GO:0031419)
1.4 4.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.4 3.7 GO:0048039 ubiquinone binding(GO:0048039)
0.0 3.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 3.3 GO:0009055 electron carrier activity(GO:0009055)
0.1 3.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 3.2 GO:0017124 SH3 domain binding(GO:0017124)
0.8 3.1 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.0 2.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.3 2.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 2.5 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 2.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 2.5 GO:0043014 alpha-tubulin binding(GO:0043014)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_MYC_PATHWAY C-MYC pathway
0.1 4.5 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 3.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 2.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.1 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.6 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.2 PID_ARF6_PATHWAY Arf6 signaling events
0.1 0.7 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.4 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.3 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.2 PID_ERBB4_PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 39.7 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 5.4 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ Genes involved in Cyclin E associated events during G1/S transition
0.2 3.7 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 2.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 2.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.3 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 2.1 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 1.8 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 1.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 1.2 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 0.9 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane