Motif ID: SIX6

Z-value: 0.496


Transcription factors associated with SIX6:

Gene SymbolEntrez IDGene Name
SIX6 ENSG00000184302.6 SIX6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SIX6hg19_v2_chr14_+_60975644_609756730.272.0e-01Click!


Activity profile for motif SIX6.

activity profile for motif SIX6


Sorted Z-values histogram for motif SIX6

Sorted Z-values for motif SIX6



Network of associatons between targets according to the STRING database.



First level regulatory network of SIX6

PNG image of the network

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Top targets:


Showing 1 to 20 of 148 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_80263506 0.953 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr3_-_111314230 0.731 ENST00000317012.4
 ZBED2
zinc finger, BED-type containing 2
chr12_-_28122980 0.667 ENST00000395868.3
ENST00000534890.1
 PTHLH

parathyroid hormone-like hormone

chr2_-_88427568 0.614 ENST00000393750.3
ENST00000295834.3
 FABP1

fatty acid binding protein 1, liver

chr12_-_121477039 0.571 ENST00000257570.5
 OASL
2'-5'-oligoadenylate synthetase-like
chr12_-_28123206 0.523 ENST00000542963.1
ENST00000535992.1
 PTHLH

parathyroid hormone-like hormone

chr12_-_14849470 0.521 ENST00000261170.3
 GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr1_+_21880560 0.480 ENST00000425315.2
 ALPL
alkaline phosphatase, liver/bone/kidney
chr8_+_67405438 0.469 ENST00000305454.3
 C8orf46
chromosome 8 open reading frame 46
chr12_-_121476959 0.467 ENST00000339275.5
 OASL
2'-5'-oligoadenylate synthetase-like
chr3_+_8543393 0.459 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
 LMCD1


LIM and cysteine-rich domains 1


chr12_+_119616447 0.443 ENST00000281938.2
 HSPB8
heat shock 22kDa protein 8
chr19_-_44031375 0.440 ENST00000292147.2
 ETHE1
ethylmalonic encephalopathy 1
chr3_+_8543561 0.435 ENST00000397386.3
 LMCD1
LIM and cysteine-rich domains 1
chr9_-_21142144 0.433 ENST00000380229.2
 IFNW1
interferon, omega 1
chr22_+_18721427 0.418 ENST00000342888.3
 AC008132.1
Uncharacterized protein
chr13_-_20080080 0.405 ENST00000400103.2
 TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr6_+_146348782 0.391 ENST00000361719.2
ENST00000392299.2
 GRM1

glutamate receptor, metabotropic 1

chr14_+_20937538 0.339 ENST00000361505.5
ENST00000553591.1
 PNP

purine nucleoside phosphorylase

chr12_-_10978957 0.334 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 1.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 1.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 0.7 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.6 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.6 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.2 0.5 GO:0071529 cementum mineralization(GO:0071529)
0.1 0.5 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.4 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 0.3 GO:0046495 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.1 0.3 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 0.3 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.3 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.2 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.2 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.7 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 0.6 GO:0045179 apical cortex(GO:0045179)
0.0 0.6 GO:0032982 myosin filament(GO:0032982)
0.1 0.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 1.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.0 GO:0051400 BH domain binding(GO:0051400)
0.1 0.7 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.5 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.4 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.3 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.3 GO:0019864 IgG binding(GO:0019864)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.2 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.1 0.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.2 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME_OPSINS Genes involved in Opsins
0.0 0.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones