Motif ID: SMAD1

Z-value: 2.484


Transcription factors associated with SMAD1:

Gene SymbolEntrez IDGene Name
SMAD1 ENSG00000170365.5 SMAD1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD1hg19_v2_chr4_+_146402925_146402957,
hg19_v2_chr4_+_146403912_146403972		-0.761.7e-05Click!


Activity profile for motif SMAD1.

activity profile for motif SMAD1


Sorted Z-values histogram for motif SMAD1

Sorted Z-values for motif SMAD1



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51471381 24.228 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51472031 19.062 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51456321 19.038 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5
chr19_-_51471362 19.005 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr19_-_51456198 15.164 ENST00000594846.1
 KLK5
kallikrein-related peptidase 5
chr19_-_51456344 13.731 ENST00000336334.3
ENST00000593428.1
 KLK5

kallikrein-related peptidase 5

chr19_-_51466681 12.373 ENST00000456750.2
 KLK6
kallikrein-related peptidase 6
chrX_-_48328551 8.867 ENST00000376876.3
 SLC38A5
solute carrier family 38, member 5
chr2_-_113594279 8.325 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr19_+_6531010 7.700 ENST00000245817.3
 TNFSF9
tumor necrosis factor (ligand) superfamily, member 9
chrX_-_48328631 7.296 ENST00000429543.1
ENST00000317669.5
 SLC38A5

solute carrier family 38, member 5

chr15_-_74504560 7.103 ENST00000449139.2
 STRA6
stimulated by retinoic acid 6
chr12_-_52845910 6.916 ENST00000252252.3
 KRT6B
keratin 6B
chr9_+_33795533 6.907 ENST00000379405.3
 PRSS3
protease, serine, 3
chr22_+_31488433 6.846 ENST00000455608.1
 SMTN
smoothelin
chr19_-_51472222 6.559 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr19_-_51472823 6.516 ENST00000310157.2
 KLK6
kallikrein-related peptidase 6
chr10_+_88718314 6.472 ENST00000348795.4
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr1_-_153433120 6.088 ENST00000368723.3
 S100A7
S100 calcium binding protein A7
chr15_-_74504597 6.001 ENST00000416286.3
 STRA6
stimulated by retinoic acid 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,237 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 86.3 GO:0016540 protein autoprocessing(GO:0016540)
0.4 48.4 GO:0070268 cornification(GO:0070268)
8.0 47.9 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
3.8 19.1 GO:0061143 alveolar primary septum development(GO:0061143)
0.9 16.6 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
1.2 16.4 GO:0015816 glycine transport(GO:0015816)
0.4 15.2 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.5 13.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.2 11.9 GO:0006910 phagocytosis, recognition(GO:0006910)
3.0 11.8 GO:0006218 uridine catabolic process(GO:0006218)
0.3 11.6 GO:0006739 NADP metabolic process(GO:0006739)
0.1 11.5 GO:0045047 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.1 10.0 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.3 9.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 9.5 GO:0006939 smooth muscle contraction(GO:0006939)
0.3 9.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 9.3 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.5 9.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 9.1 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.8 8.9 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 380 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 111.7 GO:0030141 secretory granule(GO:0030141)
6.8 47.9 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 43.8 GO:0015629 actin cytoskeleton(GO:0015629)
0.5 32.2 GO:0001533 cornified envelope(GO:0001533)
0.7 16.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 12.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 12.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 11.6 GO:0045095 keratin filament(GO:0045095)
0.1 11.3 GO:0005811 lipid particle(GO:0005811)
0.0 11.1 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.1 10.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.4 9.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 9.7 GO:0043034 costamere(GO:0043034)
0.0 9.0 GO:0030424 axon(GO:0030424)
0.1 8.3 GO:0005882 intermediate filament(GO:0005882)
0.1 8.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 8.0 GO:0005922 connexon complex(GO:0005922)
0.9 7.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 7.2 GO:0030673 axolemma(GO:0030673)
0.2 6.9 GO:1990752 microtubule end(GO:1990752)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 741 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 179.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 32.3 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 20.6 GO:0030674 protein binding, bridging(GO:0030674)
0.2 19.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 18.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 17.7 GO:0051015 actin filament binding(GO:0051015)
0.9 16.6 GO:0036374 glutathione hydrolase activity(GO:0036374)
1.5 16.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 15.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 14.6 GO:0051183 vitamin transporter activity(GO:0051183)
0.3 13.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
2.4 12.1 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.2 10.1 GO:0030546 receptor activator activity(GO:0030546)
0.1 9.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 9.3 GO:0005504 fatty acid binding(GO:0005504)
0.5 9.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 9.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.4 8.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.5 8.6 GO:0008179 adenylate cyclase binding(GO:0008179)
1.4 8.2 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 94.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 52.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 51.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8 25.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 17.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 10.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 10.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 10.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 10.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 9.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 9.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 8.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 8.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 8.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 7.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.2 7.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 7.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 7.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 7.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.4 7.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 203 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.3 16.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 15.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.8 14.1 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.3 13.9 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.3 13.9 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.3 13.8 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 12.6 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 12.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.6 11.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 10.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 9.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 9.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 9.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.4 9.1 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.4 8.7 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 8.0 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 7.7 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.3 7.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.3 7.6 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport