Motif ID: SMAD2

Z-value: 0.628


Transcription factors associated with SMAD2:

Gene SymbolEntrez IDGene Name
SMAD2 ENSG00000175387.11 SMAD2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD2hg19_v2_chr18_-_45457192_454572780.281.8e-01Click!


Activity profile for motif SMAD2.

activity profile for motif SMAD2


Sorted Z-values histogram for motif SMAD2

Sorted Z-values for motif SMAD2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_53443963 1.350 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
 TENC1


tensin like C1 domain containing phosphatase (tensin 2)


chr10_+_72972281 1.269 ENST00000335350.6
 UNC5B
unc-5 homolog B (C. elegans)
chrX_-_48328551 1.261 ENST00000376876.3
 SLC38A5
solute carrier family 38, member 5
chrX_-_48328631 1.229 ENST00000429543.1
ENST00000317669.5
 SLC38A5

solute carrier family 38, member 5

chr12_-_6740802 1.201 ENST00000431922.1
 LPAR5
lysophosphatidic acid receptor 5
chr2_-_72375167 1.191 ENST00000001146.2
 CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr9_+_125137565 1.178 ENST00000373698.5
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr12_-_47473642 1.115 ENST00000266581.4
 AMIGO2
adhesion molecule with Ig-like domain 2
chr12_-_47473425 1.100 ENST00000550413.1
 AMIGO2
adhesion molecule with Ig-like domain 2
chrX_-_107018969 1.099 ENST00000372383.4
 TSC22D3
TSC22 domain family, member 3
chr2_+_113735575 1.087 ENST00000376489.2
ENST00000259205.4
 IL36G

interleukin 36, gamma

chr1_-_9189229 1.019 ENST00000377411.4
 GPR157
G protein-coupled receptor 157
chr12_+_47473369 0.984 ENST00000546455.1
 PCED1B
PC-esterase domain containing 1B
chr12_-_47473557 0.925 ENST00000321382.3
 AMIGO2
adhesion molecule with Ig-like domain 2
chr11_-_107729887 0.880 ENST00000525815.1
 SLC35F2
solute carrier family 35, member F2
chr16_+_31483374 0.860 ENST00000394863.3
 TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr19_-_44285401 0.851 ENST00000262888.3
 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_-_11688447 0.847 ENST00000590420.1
 ACP5
acid phosphatase 5, tartrate resistant
chr1_-_149908710 0.790 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
 MTMR11


myotubularin related protein 11


chr17_-_7297519 0.751 ENST00000576362.1
ENST00000571078.1
 TMEM256-PLSCR3

TMEM256-PLSCR3 readthrough (NMD candidate)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0015816 glycine transport(GO:0015816)
0.0 3.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.7 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.4 1.3 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.2 1.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.4 1.2 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 1.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.0 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 1.0 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 1.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.9 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 0.9 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.9 GO:0046541 saliva secretion(GO:0046541)
0.0 0.9 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.9 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 0.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.7 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.7 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 0.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.6 GO:1901621 cellular response to parathyroid hormone stimulus(GO:0071374) negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 1.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.0 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.1 0.4 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 2.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 1.7 GO:0043426 MRF binding(GO:0043426)
0.3 1.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 1.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 1.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 0.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.8 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 0.7 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.6 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.4 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.8 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.5 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.3 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors