Motif ID: SMAD2
Z-value: 0.628
Transcription factors associated with SMAD2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SMAD2 | ENSG00000175387.11 | SMAD2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD2 | hg19_v2_chr18_-_45457192_45457278 | 0.28 | 1.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) |
| 0.4 | 1.2 | GO:2001037 | tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037) |
| 0.2 | 3.2 | GO:0015816 | glycine transport(GO:0015816) |
| 0.2 | 1.7 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.2 | 0.8 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.2 | 1.0 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.2 | 1.3 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.1 | 0.4 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.1 | 0.4 | GO:1901876 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) |
| 0.1 | 0.5 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.1 | 0.4 | GO:0070898 | RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898) |
| 0.1 | 0.4 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.1 | 0.9 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) |
| 0.1 | 0.3 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.1 | 0.4 | GO:1990502 | dense core granule maturation(GO:1990502) |
| 0.1 | 0.9 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.1 | 0.7 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.1 | 0.3 | GO:0021569 | rhombomere 3 development(GO:0021569) |
| 0.1 | 1.2 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.1 | 0.5 | GO:2000543 | positive regulation of gastrulation(GO:2000543) |
| 0.1 | 0.6 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.1 | 1.0 | GO:0060019 | radial glial cell differentiation(GO:0060019) |
| 0.1 | 0.9 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.1 | 0.1 | GO:0003285 | septum secundum development(GO:0003285) |
| 0.1 | 0.2 | GO:0071393 | cellular response to progesterone stimulus(GO:0071393) |
| 0.1 | 0.3 | GO:1905075 | proepicardium development(GO:0003342) septum transversum development(GO:0003343) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075) |
| 0.1 | 0.3 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.1 | 0.3 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.1 | 0.2 | GO:1904588 | cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229) |
| 0.1 | 0.2 | GO:0006435 | threonyl-tRNA aminoacylation(GO:0006435) |
| 0.0 | 3.2 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.2 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.0 | 0.5 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 0.6 | GO:1901621 | cellular response to parathyroid hormone stimulus(GO:0071374) negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.0 | 0.2 | GO:0032185 | septin cytoskeleton organization(GO:0032185) |
| 0.0 | 0.3 | GO:0046618 | drug export(GO:0046618) |
| 0.0 | 0.7 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.0 | 0.2 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.0 | 0.1 | GO:0003335 | corneocyte development(GO:0003335) |
| 0.0 | 0.1 | GO:0048936 | neurofilament bundle assembly(GO:0033693) peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.0 | 0.4 | GO:0002097 | tRNA wobble base modification(GO:0002097) |
| 0.0 | 0.4 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.0 | 0.2 | GO:0051414 | response to cortisol(GO:0051414) |
| 0.0 | 0.1 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.0 | 0.2 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.0 | 0.3 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 1.0 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 0.2 | GO:0010593 | negative regulation of lamellipodium assembly(GO:0010593) |
| 0.0 | 0.2 | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) regulation of histone deacetylase activity(GO:1901725) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514) |
| 0.0 | 0.1 | GO:2000382 | positive regulation of mesoderm development(GO:2000382) |
| 0.0 | 0.3 | GO:0006828 | manganese ion transport(GO:0006828) negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.0 | 0.2 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.0 | 0.2 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 0.2 | GO:0043031 | negative regulation of macrophage activation(GO:0043031) |
| 0.0 | 0.1 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.0 | 0.9 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.0 | 0.1 | GO:2000490 | negative regulation of hepatic stellate cell activation(GO:2000490) |
| 0.0 | 0.1 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.0 | 0.2 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 0.0 | 0.2 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.0 | 0.9 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.1 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.0 | 0.4 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.4 | GO:0060749 | mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377) |
| 0.0 | 0.2 | GO:0060155 | platelet dense granule organization(GO:0060155) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0000126 | transcription factor TFIIIB complex(GO:0000126) |
| 0.1 | 0.3 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.1 | 1.3 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.1 | 0.4 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 0.3 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 1.1 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.2 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.0 | 0.3 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 0.2 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 0.3 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 0.1 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.0 | 0.2 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.0 | 0.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.3 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 1.0 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.1 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 0.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.4 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.0 | 0.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.3 | 3.2 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.2 | 1.2 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
| 0.2 | 1.7 | GO:0043426 | MRF binding(GO:0043426) |
| 0.2 | 0.7 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.2 | 0.9 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.1 | 0.4 | GO:0001026 | TFIIIB-type transcription factor activity(GO:0001026) |
| 0.1 | 0.3 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.1 | 0.9 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.1 | 0.3 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.1 | 0.5 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 2.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 0.2 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.1 | 0.6 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.1 | 0.8 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.1 | 0.3 | GO:0015307 | drug:proton antiporter activity(GO:0015307) |
| 0.1 | 0.9 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.1 | 0.4 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 0.2 | GO:0004829 | threonine-tRNA ligase activity(GO:0004829) |
| 0.0 | 1.9 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 1.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.8 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.1 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
| 0.0 | 0.2 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.0 | 0.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.3 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.5 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 0.2 | GO:0051022 | GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 0.0 | 0.4 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 0.2 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.0 | 0.3 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 0.0 | 0.3 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.0 | 0.2 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.3 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 0.1 | GO:0047888 | fatty acid peroxidase activity(GO:0047888) |
| 0.0 | 0.1 | GO:0031493 | nucleosomal histone binding(GO:0031493) SAM domain binding(GO:0032093) |
| 0.0 | 0.5 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 0.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.1 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.0 | 0.1 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.0 | 0.2 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 0.4 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.3 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.3 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.5 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.3 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.7 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 1.3 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 2.5 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.7 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.5 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.3 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.7 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.6 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.8 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 0.6 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.5 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
| 0.0 | 0.7 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.5 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.3 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.2 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.5 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 0.8 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
