Motif ID: SMAD4

Z-value: 1.543


Transcription factors associated with SMAD4:

Gene SymbolEntrez IDGene Name
SMAD4 ENSG00000141646.9 SMAD4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD4hg19_v2_chr18_+_48494361_48494426-0.779.1e-06Click!


Activity profile for motif SMAD4.

activity profile for motif SMAD4


Sorted Z-values histogram for motif SMAD4

Sorted Z-values for motif SMAD4



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51456321 6.481 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5
chr19_-_51456344 5.991 ENST00000336334.3
ENST00000593428.1
 KLK5

kallikrein-related peptidase 5

chr19_-_51456198 4.169 ENST00000594846.1
 KLK5
kallikrein-related peptidase 5
chr1_+_152956549 3.200 ENST00000307122.2
 SPRR1A
small proline-rich protein 1A
chrX_-_48328551 2.823 ENST00000376876.3
 SLC38A5
solute carrier family 38, member 5
chrX_-_48328631 2.757 ENST00000429543.1
ENST00000317669.5
 SLC38A5

solute carrier family 38, member 5

chr1_-_28520447 2.710 ENST00000539896.1
 PTAFR
platelet-activating factor receptor
chr1_-_24469602 2.652 ENST00000270800.1
 IL22RA1
interleukin 22 receptor, alpha 1
chr1_+_45212074 2.580 ENST00000372217.1
 KIF2C
kinesin family member 2C
chr19_-_11688447 2.549 ENST00000590420.1
 ACP5
acid phosphatase 5, tartrate resistant
chr2_-_113594279 2.535 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr5_-_39219705 2.532 ENST00000351578.6
 FYB
FYN binding protein
chr2_-_31360887 2.482 ENST00000420311.2
ENST00000356174.3
ENST00000324589.5
 GALNT14


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)


chr1_+_45212051 2.461 ENST00000372222.3
 KIF2C
kinesin family member 2C
chr19_-_11688500 2.439 ENST00000433365.2
 ACP5
acid phosphatase 5, tartrate resistant
chr7_+_48128316 2.278 ENST00000341253.4
 UPP1
uridine phosphorylase 1
chr7_+_48128194 2.275 ENST00000416681.1
ENST00000331803.4
ENST00000432131.1
 UPP1


uridine phosphorylase 1


chr22_+_30752606 2.223 ENST00000399824.2
ENST00000405659.1
ENST00000338306.3
 CCDC157


coiled-coil domain containing 157


chr5_-_39219641 2.210 ENST00000509072.1
ENST00000504542.1
ENST00000505428.1
ENST00000506557.1
 FYB



FYN binding protein



chr1_-_28520384 2.185 ENST00000305392.3
 PTAFR
platelet-activating factor receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 443 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 16.6 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 9.0 GO:0070268 cornification(GO:0070268)
0.1 7.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.4 5.8 GO:0015816 glycine transport(GO:0015816)
0.3 5.6 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
1.0 5.0 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.5 5.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 5.0 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
1.6 4.9 GO:1904298 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
0.1 4.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
1.1 4.6 GO:0006218 uridine catabolic process(GO:0006218)
0.6 3.8 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
1.2 3.6 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.4 3.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 3.3 GO:0060216 definitive hemopoiesis(GO:0060216)
1.0 3.1 GO:0046521 sphingoid catabolic process(GO:0046521)
1.0 2.9 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.8 2.5 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.2 2.4 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.2 2.4 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 17.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 11.0 GO:0005925 focal adhesion(GO:0005925)
0.1 9.4 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 8.6 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 7.5 GO:0044297 cell body(GO:0044297)
0.1 7.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 7.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 6.1 GO:0005882 intermediate filament(GO:0005882)
0.1 5.8 GO:0001533 cornified envelope(GO:0001533)
0.3 4.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 3.6 GO:0097228 sperm principal piece(GO:0097228)
0.0 3.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 3.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 3.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.3 GO:0043209 myelin sheath(GO:0043209)
1.1 3.2 GO:0031523 Myb complex(GO:0031523)
0.0 2.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 2.6 GO:0031528 microvillus membrane(GO:0031528)
0.8 2.5 GO:0005607 laminin-2 complex(GO:0005607)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 296 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 5.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 5.6 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 5.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.0 5.2 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.4 5.2 GO:0008199 ferric iron binding(GO:0008199)
0.2 5.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.5 5.0 GO:0019237 centromeric DNA binding(GO:0019237)
1.0 4.9 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.0 4.6 GO:0045296 cadherin binding(GO:0045296)
1.2 3.6 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.3 3.5 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.3 3.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.7 3.3 GO:0050436 microfibril binding(GO:0050436)
0.8 3.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 3.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 3.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.9 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 6.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.3 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.1 4.7 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 4.4 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 4.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 3.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 2.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.3 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 2.2 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 1.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.5 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 5.3 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 5.0 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 4.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 4.6 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 4.1 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 3.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 3.5 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 3.4 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 3.2 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 2.9 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.0 2.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 2.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.1 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling