Motif ID: SOX1

Z-value: 0.523


Transcription factors associated with SOX1:

Gene SymbolEntrez IDGene Name
SOX1 ENSG00000182968.3 SOX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX1hg19_v2_chr13_+_112721913_1127219130.592.3e-03Click!


Activity profile for motif SOX1.

activity profile for motif SOX1


Sorted Z-values histogram for motif SOX1

Sorted Z-values for motif SOX1



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 124 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_125496619 1.588 ENST00000532669.1
ENST00000278916.3
 CHEK1

checkpoint kinase 1

chr1_+_152957707 1.548 ENST00000368762.1
 SPRR1A
small proline-rich protein 1A
chr1_+_152975488 1.498 ENST00000542696.1
 SPRR3
small proline-rich protein 3
chr13_+_109248500 1.336 ENST00000356711.2
 MYO16
myosin XVI
chr11_+_125496400 1.178 ENST00000524737.1
 CHEK1
checkpoint kinase 1
chr9_-_123638633 1.144 ENST00000456291.1
 PHF19
PHD finger protein 19
chr11_+_125496124 1.106 ENST00000533778.2
ENST00000534070.1
 CHEK1

checkpoint kinase 1

chr7_+_142457315 1.068 ENST00000486171.1
ENST00000311737.7
 PRSS1

protease, serine, 1 (trypsin 1)

chr2_+_11864458 0.993 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
 LPIN1


lipin 1


chr16_+_12059050 0.982 ENST00000396495.3
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr16_+_12058961 0.929 ENST00000053243.1
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr3_-_189840223 0.693 ENST00000427335.2
 LEPREL1
leprecan-like 1
chrX_+_2976652 0.665 ENST00000537104.1
 ARSF
arylsulfatase F
chr1_-_89641680 0.661 ENST00000294671.2
 GBP7
guanylate binding protein 7
chr12_+_75874460 0.615 ENST00000266659.3
 GLIPR1
GLI pathogenesis-related 1
chr20_-_48747662 0.613 ENST00000371656.2
 TMEM189
transmembrane protein 189
chr13_+_49280951 0.582 ENST00000282018.3
 CYSLTR2
cysteinyl leukotriene receptor 2
chr3_+_136676851 0.535 ENST00000309741.5
 IL20RB
interleukin 20 receptor beta
chr3_+_136676707 0.499 ENST00000329582.4
 IL20RB
interleukin 20 receptor beta
chr4_+_156680153 0.490 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
 GUCY1B3




guanylate cyclase 1, soluble, beta 3





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.9 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 3.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 2.2 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 1.3 GO:0021549 cerebellum development(GO:0021549)
0.1 1.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 1.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 1.0 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 1.0 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.9 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 0.6 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 0.6 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.6 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.1 0.5 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.4 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 0.4 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.1 0.4 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.3 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.0 GO:0001533 cornified envelope(GO:0001533)
0.0 2.4 GO:0016459 myosin complex(GO:0016459)
0.0 1.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.4 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 1.7 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 1.0 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.7 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 0.6 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.6 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.5 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 0.4 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.4 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1 0.4 GO:0051373 FATZ binding(GO:0051373)
0.0 0.4 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.3 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.2 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.2 GO:0019862 IgA binding(GO:0019862)
0.0 0.2 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.2 GO:0003696 satellite DNA binding(GO:0003696)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.6 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.5 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation