Motif ID: SOX11

Z-value: 0.660


Transcription factors associated with SOX11:

Gene SymbolEntrez IDGene Name
SOX11 ENSG00000176887.5 SOX11

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX11hg19_v2_chr2_+_5832799_5832799-0.252.5e-01Click!


Activity profile for motif SOX11.

activity profile for motif SOX11


Sorted Z-values histogram for motif SOX11

Sorted Z-values for motif SOX11



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX11

PNG image of the network

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Top targets:


Showing 1 to 20 of 160 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_7921090 5.653 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr11_+_61976137 2.229 ENST00000244930.4
 SCGB2A1
secretoglobin, family 2A, member 1
chr6_-_32557610 2.159 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr14_+_96949319 2.122 ENST00000554706.1
 AK7
adenylate kinase 7
chr3_-_112564797 1.738 ENST00000398214.1
ENST00000448932.1
 CD200R1L

CD200 receptor 1-like

chr12_+_56075330 1.188 ENST00000394252.3
 METTL7B
methyltransferase like 7B
chr4_+_159443090 1.184 ENST00000343542.5
ENST00000470033.1
 RXFP1

relaxin/insulin-like family peptide receptor 1

chr8_-_128960591 1.151 ENST00000539634.1
 TMEM75
transmembrane protein 75
chr1_+_244515930 1.066 ENST00000366537.1
ENST00000308105.4
 C1orf100

chromosome 1 open reading frame 100

chr10_-_25305011 1.055 ENST00000331161.4
ENST00000376363.1
 ENKUR

enkurin, TRPC channel interacting protein

chr5_+_140213815 0.977 ENST00000525929.1
ENST00000378125.3
 PCDHA7

protocadherin alpha 7

chr5_+_140248518 0.916 ENST00000398640.2
 PCDHA11
protocadherin alpha 11
chrX_-_132231123 0.842 ENST00000511190.1
 USP26
ubiquitin specific peptidase 26
chr6_-_76072719 0.842 ENST00000370020.1
 FILIP1
filamin A interacting protein 1
chr2_+_42104692 0.838 ENST00000398796.2
ENST00000442214.1
 AC104654.1

AC104654.1

chr4_+_72204755 0.805 ENST00000512686.1
ENST00000340595.3
 SLC4A4

solute carrier family 4 (sodium bicarbonate cotransporter), member 4

chr6_+_159071015 0.788 ENST00000360448.3
 SYTL3
synaptotagmin-like 3
chr4_-_105416039 0.753 ENST00000394767.2
 CXXC4
CXXC finger protein 4
chr2_+_169658928 0.692 ENST00000317647.7
ENST00000445023.2
 NOSTRIN

nitric oxide synthase trafficking

chr2_+_169659121 0.670 ENST00000397206.2
ENST00000397209.2
ENST00000421711.2
 NOSTRIN


nitric oxide synthase trafficking



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.7 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 2.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 2.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.0 2.2 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 2.1 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 1.4 GO:0050999 regulation of nitric-oxide synthase activity(GO:0050999)
0.0 1.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.8 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 0.6 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 0.5 GO:0034239 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.0 0.5 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.5 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.4 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.4 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.4 GO:0006012 galactose metabolic process(GO:0006012)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.1 GO:0097228 sperm principal piece(GO:0097228)
0.0 1.1 GO:0035580 specific granule lumen(GO:0035580)
0.1 0.3 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.2 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.1 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.7 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.3 2.1 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 1.9 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.8 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.6 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.5 GO:0005549 odorant binding(GO:0005549)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.4 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.0 0.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.3 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 0.3 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.2 GO:0030366 molybdopterin synthase activity(GO:0030366)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 2.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.4 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 1.0 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 0.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME_OPSINS Genes involved in Opsins
0.0 0.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane