Motif ID: SOX13_SOX12

Z-value: 1.068

Transcription factors associated with SOX13_SOX12:

Gene SymbolEntrez IDGene Name
SOX12 ENSG00000177732.6 SOX12
SOX13 ENSG00000143842.10 SOX13

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX13hg19_v2_chr1_+_204042723_2040427840.223.0e-01Click!
SOX12hg19_v2_chr20_+_306221_306239-0.193.7e-01Click!


Activity profile for motif SOX13_SOX12.

activity profile for motif SOX13_SOX12


Sorted Z-values histogram for motif SOX13_SOX12

Sorted Z-values for motif SOX13_SOX12



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX13_SOX12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_102928009 8.589 ENST00000404917.2
ENST00000447231.1
 IL1RL1

interleukin 1 receptor-like 1

chr10_+_118187379 3.548 ENST00000369230.3
 PNLIPRP3
pancreatic lipase-related protein 3
chr12_-_91505608 3.410 ENST00000266718.4
 LUM
lumican
chr4_-_69111401 3.080 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr4_-_57547454 2.494 ENST00000556376.2
 HOPX
HOP homeobox
chr4_-_74864386 2.353 ENST00000296027.4
 CXCL5
chemokine (C-X-C motif) ligand 5
chr1_+_152975488 2.273 ENST00000542696.1
 SPRR3
small proline-rich protein 3
chr1_-_153433120 1.898 ENST00000368723.3
 S100A7
S100 calcium binding protein A7
chr7_+_100770328 1.808 ENST00000223095.4
ENST00000445463.2
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr1_+_153388993 1.792 ENST00000368729.4
 S100A7A
S100 calcium binding protein A7A
chr12_+_4385230 1.588 ENST00000536537.1
 CCND2
cyclin D2
chr7_+_134576317 1.585 ENST00000424922.1
ENST00000495522.1
 CALD1

caldesmon 1

chr1_-_153013588 1.462 ENST00000360379.3
 SPRR2D
small proline-rich protein 2D
chr3_+_186358148 1.411 ENST00000382134.3
ENST00000265029.3
 FETUB

fetuin B

chr12_-_8803128 1.410 ENST00000543467.1
 MFAP5
microfibrillar associated protein 5
chr20_-_5426332 1.385 ENST00000420529.1
 LINC00658
long intergenic non-protein coding RNA 658
chr7_-_121944491 1.339 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
 FEZF1


FEZ family zinc finger 1


chr17_-_38859996 1.319 ENST00000264651.2
 KRT24
keratin 24
chr5_-_147211226 1.292 ENST00000296695.5
 SPINK1
serine peptidase inhibitor, Kazal type 1
chr2_-_216878305 1.280 ENST00000263268.6
 MREG
melanoregulin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 226 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 8.4 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 6.7 GO:0018149 peptide cross-linking(GO:0018149)
0.1 6.1 GO:0097435 fibril organization(GO:0097435)
0.5 3.4 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.5 2.8 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.1 2.6 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 2.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.4 2.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 2.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 2.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 2.2 GO:0031424 keratinization(GO:0031424)
0.0 2.0 GO:0002377 immunoglobulin production(GO:0002377)
0.2 1.9 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.6 1.8 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 1.7 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.1 1.6 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 1.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2 1.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.3 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.0 1.3 GO:0007339 binding of sperm to zona pellucida(GO:0007339)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 6.7 GO:0001533 cornified envelope(GO:0001533)
0.2 4.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 3.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 3.3 GO:0030478 actin cap(GO:0030478)
0.0 3.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 2.8 GO:0072562 blood microparticle(GO:0072562)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.1 2.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 2.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.9 GO:0005901 caveola(GO:0005901)
0.0 1.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 1.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 1.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.1 GO:0030673 axolemma(GO:0030673)
0.1 1.0 GO:0033503 HULC complex(GO:0033503)
0.1 1.0 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 8.4 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 7.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 7.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 6.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 4.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 3.3 GO:0005523 tropomyosin binding(GO:0005523)
0.2 2.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 2.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 2.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.4 2.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 2.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.7 GO:0043621 protein self-association(GO:0043621)
0.0 1.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 1.4 GO:0034235 GPI anchor binding(GO:0034235)
0.0 1.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.0 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 1.0 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 2.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 2.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.9 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 3.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 2.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 2.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.0 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.9 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 1.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.6 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.4 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 1.2 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.1 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.9 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 0.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones