Motif ID: SOX17

Z-value: 0.811


Transcription factors associated with SOX17:

Gene SymbolEntrez IDGene Name
SOX17 ENSG00000164736.5 SOX17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX17hg19_v2_chr8_+_55370487_55370503-0.395.9e-02Click!


Activity profile for motif SOX17.

activity profile for motif SOX17


Sorted Z-values histogram for motif SOX17

Sorted Z-values for motif SOX17



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_71533055 7.020 ENST00000552128.1
 TSPAN8
tetraspanin 8
chr8_+_72587535 2.750 ENST00000519840.1
ENST00000521131.1
 RP11-1144P22.1

RP11-1144P22.1

chrY_+_2709906 2.680 ENST00000430575.1
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr13_-_39564993 2.629 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr6_-_32920794 2.592 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
 HLA-DMA


XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha


Uncharacterized protein
chr3_-_19975665 2.399 ENST00000295824.9
ENST00000389256.4
 EFHB

EF-hand domain family, member B

chr17_+_41158742 1.970 ENST00000415816.2
ENST00000438323.2
 IFI35

interferon-induced protein 35

chr6_-_52668605 1.873 ENST00000334575.5
 GSTA1
glutathione S-transferase alpha 1
chrX_-_38186811 1.830 ENST00000318842.7
 RPGR
retinitis pigmentosa GTPase regulator
chr14_-_93673353 1.762 ENST00000556566.1
ENST00000306954.4
 C14orf142

chromosome 14 open reading frame 142

chr6_-_52710893 1.597 ENST00000284562.2
 GSTA5
glutathione S-transferase alpha 5
chr3_-_167371740 1.592 ENST00000466760.1
ENST00000479765.1
 WDR49

WD repeat domain 49

chr5_-_16509101 1.569 ENST00000399793.2
 FAM134B
family with sequence similarity 134, member B
chr17_+_68100989 1.437 ENST00000585558.1
ENST00000392670.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr8_+_110098850 1.427 ENST00000518632.1
 TRHR
thyrotropin-releasing hormone receptor
chr2_+_233527443 1.344 ENST00000410095.1
 EFHD1
EF-hand domain family, member D1
chr19_-_10764509 1.241 ENST00000591501.1
 ILF3-AS1
ILF3 antisense RNA 1 (head to head)
chr5_-_41213607 1.209 ENST00000337836.5
ENST00000433294.1
 C6

complement component 6

chr12_-_15374343 1.193 ENST00000256953.2
ENST00000546331.1
 RERG

RAS-like, estrogen-regulated, growth inhibitor

chr4_-_100212132 1.183 ENST00000209668.2
 ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 3.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.6 2.6 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 2.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 2.3 GO:0016266 O-glycan processing(GO:0016266)
0.1 1.9 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.0 1.8 GO:0042073 intraciliary transport(GO:0042073)
0.0 1.5 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 1.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.4 GO:0010107 potassium ion import(GO:0010107)
0.0 1.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.3 GO:0044458 motile cilium assembly(GO:0044458)
0.3 1.2 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.3 1.1 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.2 1.1 GO:0070995 NADPH oxidation(GO:0070995)
0.2 1.1 GO:0015798 myo-inositol transport(GO:0015798)
0.0 1.1 GO:0003334 keratinocyte development(GO:0003334)
0.3 1.0 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 1.0 GO:0006477 protein sulfation(GO:0006477)
0.1 1.0 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.7 GO:0005844 polysome(GO:0005844)
0.0 2.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 1.5 GO:0097224 sperm connecting piece(GO:0097224)
0.1 1.2 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.2 GO:0000439 core TFIIH complex(GO:0000439)
0.2 1.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 1.1 GO:0035580 specific granule lumen(GO:0035580)
0.1 1.0 GO:0042611 MHC protein complex(GO:0042611) MHC class I protein complex(GO:0042612)
0.3 0.9 GO:0005608 laminin-3 complex(GO:0005608)
0.0 0.9 GO:0030057 desmosome(GO:0030057)
0.1 0.8 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.7 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.7 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.6 GO:0097362 MCM8-MCM9 complex(GO:0097362)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.1 0.5 GO:0034457 Mpp10 complex(GO:0034457)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 GO:0005178 integrin binding(GO:0005178)
0.1 5.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 2.6 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 2.6 GO:0019843 rRNA binding(GO:0019843)
0.3 2.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.5 GO:0032027 myosin light chain binding(GO:0032027)
0.1 1.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.2 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 1.1 GO:0031013 troponin I binding(GO:0031013)
0.1 1.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 1.0 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 1.0 GO:0042605 peptide antigen binding(GO:0042605)
0.0 1.0 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3 0.8 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.1 0.8 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.8 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.0 ST_ADRENERGIC Adrenergic Pathway
0.0 0.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 2.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.5 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 1.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.0 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.0 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.8 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.6 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 0.4 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)