Motif ID: SOX18

Z-value: 0.881


Transcription factors associated with SOX18:

Gene SymbolEntrez IDGene Name
SOX18 ENSG00000203883.5 SOX18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX18hg19_v2_chr20_-_62680984_626809990.029.2e-01Click!


Activity profile for motif SOX18.

activity profile for motif SOX18


Sorted Z-values histogram for motif SOX18

Sorted Z-values for motif SOX18



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX18

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_31488433 3.792 ENST00000455608.1
SMTN
smoothelin
chr19_-_43382142 2.970 ENST00000597058.1
PSG1
pregnancy specific beta-1-glycoprotein 1
chr5_-_136834982 2.858 ENST00000510689.1
ENST00000394945.1
SPOCK1

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

chr1_+_171154347 2.150 ENST00000209929.7
ENST00000441535.1
FMO2

flavin containing monooxygenase 2 (non-functional)

chr13_+_78109884 2.025 ENST00000377246.3
ENST00000349847.3
SCEL

sciellin

chr4_-_57524061 1.978 ENST00000508121.1
HOPX
HOP homeobox
chr13_+_78109804 1.952 ENST00000535157.1
SCEL
sciellin
chr9_-_99064386 1.801 ENST00000375262.2
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr7_-_142120321 1.772 ENST00000390377.1
TRBV7-7
T cell receptor beta variable 7-7
chr19_+_40146534 1.757 ENST00000392051.3
LGALS16
lectin, galactoside-binding, soluble, 16
chr16_+_66637777 1.621 ENST00000563672.1
ENST00000424011.2
CMTM3

CKLF-like MARVEL transmembrane domain containing 3

chr8_+_7397150 1.501 ENST00000533250.1
RP11-1118M6.1
proline rich 23 domain containing 1
chr9_-_99064429 1.470 ENST00000375263.3
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr2_-_208031943 1.460 ENST00000421199.1
ENST00000457962.1
KLF7

Kruppel-like factor 7 (ubiquitous)

chr16_+_66638003 1.405 ENST00000562357.1
ENST00000360086.4
ENST00000562707.1
ENST00000361909.4
ENST00000460097.1
ENST00000565666.1
CMTM3





CKLF-like MARVEL transmembrane domain containing 3





chr19_+_7030589 1.370 ENST00000329753.5
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr19_-_7040190 1.364 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr17_-_17184605 1.214 ENST00000268717.5
COPS3
COP9 signalosome subunit 3
chr6_-_27880174 1.148 ENST00000303324.2
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr3_+_57882024 1.130 ENST00000494088.1
SLMAP
sarcolemma associated protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0006939 smooth muscle contraction(GO:0006939)
0.5 3.3 GO:0061370 testosterone biosynthetic process(GO:0061370)
0.0 3.2 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.2 3.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 3.0 GO:0007565 female pregnancy(GO:0007565)
0.0 2.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 2.7 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.4 2.2 GO:0070995 NADPH oxidation(GO:0070995)
0.0 2.2 GO:0048813 dendrite morphogenesis(GO:0048813)
0.1 2.1 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.1 2.0 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 1.8 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 1.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 1.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.2 GO:0000338 protein deneddylation(GO:0000338)
0.2 1.1 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 1.1 GO:0051639 actin filament network formation(GO:0051639)
0.1 1.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.1 GO:0051775 response to redox state(GO:0051775)
0.0 1.1 GO:0060216 definitive hemopoiesis(GO:0060216)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 GO:0001533 cornified envelope(GO:0001533)
0.1 2.9 GO:0033268 node of Ranvier(GO:0033268)
0.1 2.0 GO:0005685 U1 snRNP(GO:0005685)
0.0 1.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 1.4 GO:0001741 XY body(GO:0001741)
0.0 1.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 1.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 1.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 0.8 GO:0005602 complement component C1 complex(GO:0005602)
0.1 0.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.2 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.7 GO:0033503 HULC complex(GO:0033503)
0.1 0.7 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.5 3.3 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 2.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 2.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 2.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.3 2.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.4 1.8 GO:0030395 lactose binding(GO:0030395)
0.0 1.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 1.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 1.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 1.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 1.0 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.3 0.9 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.6 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 2.8 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 2.2 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 2.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.1 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.1 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.9 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.7 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.6 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation