Motif ID: SOX21

Z-value: 0.442


Transcription factors associated with SOX21:

Gene SymbolEntrez IDGene Name
SOX21 ENSG00000125285.4 SOX21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_953643890.223.0e-01Click!


Activity profile for motif SOX21.

activity profile for motif SOX21


Sorted Z-values histogram for motif SOX21

Sorted Z-values for motif SOX21



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX21

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_69313145 1.751 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr1_+_152881014 1.058 ENST00000368764.3
ENST00000392667.2
 IVL

involucrin

chr11_+_35201826 0.768 ENST00000531873.1
 CD44
CD44 molecule (Indian blood group)
chr12_-_89746173 0.689 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr1_-_54303934 0.656 ENST00000537333.1
 NDC1
NDC1 transmembrane nucleoporin
chr4_-_39034542 0.650 ENST00000344606.6
 TMEM156
transmembrane protein 156
chr19_+_16308659 0.640 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
 AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr19_+_16308711 0.613 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
 AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr15_-_80263506 0.607 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr6_+_31371337 0.575 ENST00000449934.2
ENST00000421350.1
 MICA

MHC class I polypeptide-related sequence A

chr12_+_123011776 0.572 ENST00000450485.2
ENST00000333479.7
 KNTC1

kinetochore associated 1

chr11_+_5410607 0.541 ENST00000328611.3
 OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr7_-_73133959 0.520 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
 STX1A



syntaxin 1A (brain)



chr8_-_143961236 0.376 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
 CYP11B1


cytochrome P450, family 11, subfamily B, polypeptide 1


chrX_+_2984874 0.373 ENST00000359361.2
 ARSF
arylsulfatase F
chr19_+_7030589 0.367 ENST00000329753.5
 MBD3L5
methyl-CpG binding domain protein 3-like 5
chr19_-_7040190 0.326 ENST00000381394.4
 MBD3L4
methyl-CpG binding domain protein 3-like 4
chr1_-_151148492 0.311 ENST00000295314.4
 TMOD4
tropomodulin 4 (muscle)
chr12_+_1099675 0.299 ENST00000545318.2
 ERC1
ELKS/RAB6-interacting/CAST family member 1
chr4_-_177190364 0.295 ENST00000296525.3
 ASB5
ankyrin repeat and SOCS box containing 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.4 1.1 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.8 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.7 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.0 0.7 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 0.6 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.6 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.5 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.4 GO:0035865 cellular response to potassium ion(GO:0035865)
0.1 0.3 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.1 0.3 GO:0000255 allantoin metabolic process(GO:0000255) cellular amide catabolic process(GO:0043605)
0.1 0.3 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0071321 cellular response to cGMP(GO:0071321)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.1 GO:0001533 cornified envelope(GO:0001533)
0.1 0.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 0.7 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.6 GO:1990423 RZZ complex(GO:1990423)
0.1 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.4 GO:0005605 basal lamina(GO:0005605)
0.1 0.3 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.2 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.6 GO:0051400 BH domain binding(GO:0051400)
0.0 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.4 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.3 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.3 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.2 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.1 GO:0047718 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.0 0.1 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.1 GO:0070905 serine binding(GO:0070905)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.0 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.5 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels