Motif ID: SOX21

Z-value: 0.442


Transcription factors associated with SOX21:

Gene SymbolEntrez IDGene Name
SOX21 ENSG00000125285.4 SOX21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_953643890.223.0e-01Click!


Activity profile for motif SOX21.

activity profile for motif SOX21


Sorted Z-values histogram for motif SOX21

Sorted Z-values for motif SOX21



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX21

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_69313145 1.751 ENST00000305363.4
 TMPRSS11E
transmembrane protease, serine 11E
chr1_+_152881014 1.058 ENST00000368764.3
ENST00000392667.2
 IVL

involucrin

chr11_+_35201826 0.768 ENST00000531873.1
 CD44
CD44 molecule (Indian blood group)
chr12_-_89746173 0.689 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr1_-_54303934 0.656 ENST00000537333.1
 NDC1
NDC1 transmembrane nucleoporin
chr4_-_39034542 0.650 ENST00000344606.6
 TMEM156
transmembrane protein 156
chr19_+_16308659 0.640 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
 AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr19_+_16308711 0.613 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
 AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr15_-_80263506 0.607 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr6_+_31371337 0.575 ENST00000449934.2
ENST00000421350.1
 MICA

MHC class I polypeptide-related sequence A

chr12_+_123011776 0.572 ENST00000450485.2
ENST00000333479.7
 KNTC1

kinetochore associated 1

chr11_+_5410607 0.541 ENST00000328611.3
 OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr7_-_73133959 0.520 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
 STX1A



syntaxin 1A (brain)



chr8_-_143961236 0.376 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
 CYP11B1


cytochrome P450, family 11, subfamily B, polypeptide 1


chrX_+_2984874 0.373 ENST00000359361.2
 ARSF
arylsulfatase F
chr19_+_7030589 0.367 ENST00000329753.5
 MBD3L5
methyl-CpG binding domain protein 3-like 5
chr19_-_7040190 0.326 ENST00000381394.4
 MBD3L4
methyl-CpG binding domain protein 3-like 4
chr1_-_151148492 0.311 ENST00000295314.4
 TMOD4
tropomodulin 4 (muscle)
chr12_+_1099675 0.299 ENST00000545318.2
 ERC1
ELKS/RAB6-interacting/CAST family member 1
chr4_-_177190364 0.295 ENST00000296525.3
 ASB5
ankyrin repeat and SOCS box containing 5
chr1_+_67632083 0.281 ENST00000347310.5
ENST00000371002.1
 IL23R

interleukin 23 receptor

chr2_+_3705785 0.254 ENST00000252505.3
 ALLC
allantoicase
chr14_-_107170409 0.248 ENST00000390633.2
 IGHV1-69
immunoglobulin heavy variable 1-69
chr3_+_57994127 0.239 ENST00000490882.1
ENST00000295956.4
ENST00000358537.3
ENST00000429972.2
ENST00000348383.5
ENST00000357272.4
 FLNB





filamin B, beta





chrX_-_39186610 0.228 ENST00000429281.1
ENST00000448597.1
 RP11-265P11.2

RP11-265P11.2

chr17_-_71410794 0.222 ENST00000424778.1
 SDK2
sidekick cell adhesion molecule 2
chr9_-_14910990 0.221 ENST00000380881.4
ENST00000422223.2
 FREM1

FRAS1 related extracellular matrix 1

chr6_-_3195981 0.215 ENST00000425384.2
ENST00000435043.2
 RP1-40E16.9

RP1-40E16.9

chr9_+_105757590 0.212 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr12_+_20522179 0.205 ENST00000359062.3
 PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr3_-_164875850 0.188 ENST00000472120.1
 RP11-747D18.1
RP11-747D18.1
chr9_-_104249400 0.176 ENST00000374848.3
 TMEM246
transmembrane protein 246
chrY_+_14813160 0.175 ENST00000338981.3
 USP9Y
ubiquitin specific peptidase 9, Y-linked
chr16_-_15149828 0.172 ENST00000566419.1
ENST00000568320.1
 NTAN1

N-terminal asparagine amidase

chr6_-_112575912 0.171 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
 LAMA4


laminin, alpha 4


chr6_-_112575838 0.168 ENST00000455073.1
 LAMA4
laminin, alpha 4
chr4_-_122854612 0.166 ENST00000264811.5
 TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr4_-_83931862 0.162 ENST00000506560.1
ENST00000442461.2
ENST00000446851.2
ENST00000340417.3
 LIN54



lin-54 homolog (C. elegans)



chr12_-_10324716 0.161 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
 OLR1



oxidized low density lipoprotein (lectin-like) receptor 1



chr8_+_26150628 0.161 ENST00000523925.1
ENST00000315985.7
 PPP2R2A

protein phosphatase 2, regulatory subunit B, alpha

chr18_+_29769978 0.159 ENST00000269202.6
ENST00000581447.1
 MEP1B

meprin A, beta

chr10_+_5005445 0.149 ENST00000380872.4
 AKR1C1
aldo-keto reductase family 1, member C1
chr19_-_2783363 0.139 ENST00000221566.2
 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr10_-_13276329 0.138 ENST00000378681.3
ENST00000463405.2
 UCMA

upper zone of growth plate and cartilage matrix associated

chr15_+_58702742 0.129 ENST00000356113.6
ENST00000414170.3
 LIPC

lipase, hepatic

chr22_+_23063100 0.127 ENST00000390309.2
 IGLV3-19
immunoglobulin lambda variable 3-19
chr17_+_66245341 0.125 ENST00000577985.1
 AMZ2
archaelysin family metallopeptidase 2
chr7_-_37026108 0.121 ENST00000396045.3
 ELMO1
engulfment and cell motility 1
chr20_+_43343886 0.121 ENST00000190983.4
 WISP2
WNT1 inducible signaling pathway protein 2
chrX_+_36053908 0.118 ENST00000378660.2
 CHDC2
calponin homology domain containing 2
chr7_+_2394445 0.106 ENST00000360876.4
ENST00000413917.1
ENST00000397011.2
 EIF3B


eukaryotic translation initiation factor 3, subunit B


chr12_-_1058685 0.106 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
 RAD52





RAD52 homolog (S. cerevisiae)





chr3_+_37035289 0.102 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
 MLH1




mutL homolog 1




chr3_+_37035263 0.099 ENST00000458205.2
ENST00000539477.1
 MLH1

mutL homolog 1

chr6_-_112575758 0.098 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
 LAMA4



laminin, alpha 4



chr8_-_19459993 0.098 ENST00000454498.2
ENST00000520003.1
 CSGALNACT1

chondroitin sulfate N-acetylgalactosaminyltransferase 1

chr9_+_99691286 0.096 ENST00000372322.3
 NUTM2G
NUT family member 2G
chrX_+_65384052 0.093 ENST00000336279.5
ENST00000458621.1
 HEPH

hephaestin

chr5_-_179045199 0.088 ENST00000523921.1
 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr4_-_103746683 0.087 ENST00000504211.1
ENST00000508476.1
 UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr17_+_60457914 0.083 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
 EFCAB3


EF-hand calcium binding domain 3


chr19_+_42381173 0.082 ENST00000221972.3
 CD79A
CD79a molecule, immunoglobulin-associated alpha
chr4_-_103746924 0.079 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
 UBE2D3


ubiquitin-conjugating enzyme E2D 3


chr1_+_158901329 0.077 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
 PYHIN1




pyrin and HIN domain family, member 1




chr4_-_103747011 0.076 ENST00000350435.7
 UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr22_+_39353527 0.076 ENST00000249116.2
 APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr1_-_26394114 0.075 ENST00000374272.3
 TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr19_-_54784937 0.070 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
 LILRB2


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2


chr7_+_120702819 0.069 ENST00000423795.1
 CPED1
cadherin-like and PC-esterase domain containing 1
chr17_-_18266660 0.069 ENST00000582653.1
ENST00000352886.6
 SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr22_-_40929812 0.064 ENST00000422851.1
 MKL1
megakaryoblastic leukemia (translocation) 1
chr3_+_38537960 0.062 ENST00000453767.1
 EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr3_+_37034823 0.051 ENST00000231790.2
ENST00000456676.2
 MLH1

mutL homolog 1

chr11_+_114168085 0.045 ENST00000541754.1
 NNMT
nicotinamide N-methyltransferase
chr1_+_146714291 0.044 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
 CHD1L



chromodomain helicase DNA binding protein 1-like



chr6_+_42531798 0.042 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
 UBR2


ubiquitin protein ligase E3 component n-recognin 2


chr6_+_140175987 0.041 ENST00000414038.1
ENST00000431609.1
 RP5-899B16.1

RP5-899B16.1

chr19_+_18682531 0.040 ENST00000596304.1
ENST00000430157.2
 UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

chr14_+_50291993 0.039 ENST00000595378.1
 AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr19_-_45737469 0.039 ENST00000413988.1
 EXOC3L2
exocyst complex component 3-like 2
chr1_+_199996733 0.037 ENST00000236914.3
 NR5A2
nuclear receptor subfamily 5, group A, member 2
chr3_+_141103634 0.035 ENST00000507722.1
 ZBTB38
zinc finger and BTB domain containing 38
chr16_-_15982440 0.033 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
 FOPNL






FGFR1OP N-terminal like






chr6_-_121655593 0.031 ENST00000398212.2
 TBC1D32
TBC1 domain family, member 32
chrX_+_52927576 0.030 ENST00000416841.2
 FAM156B
family with sequence similarity 156, member B
chr7_-_14942944 0.028 ENST00000403951.2
 DGKB
diacylglycerol kinase, beta 90kDa
chr10_-_71169031 0.025 ENST00000373307.1
 TACR2
tachykinin receptor 2
chr3_+_155838337 0.021 ENST00000490337.1
ENST00000389636.5
 KCNAB1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr5_+_175875349 0.017 ENST00000261942.6
 FAF2
Fas associated factor family member 2
chr11_-_8285405 0.013 ENST00000335790.3
ENST00000534484.1
 LMO1

LIM domain only 1 (rhombotin 1)

chr5_+_140579162 0.012 ENST00000536699.1
ENST00000354757.3
 PCDHB11

protocadherin beta 11

chr3_+_38537763 0.005 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
 EXOG


endo/exonuclease (5'-3'), endonuclease G-like


chr5_-_95158644 0.003 ENST00000237858.6
 GLRX
glutaredoxin (thioltransferase)
chr5_-_95158375 0.002 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
 GLRX



glutaredoxin (thioltransferase)



chr19_+_42381337 0.000 ENST00000597454.1
ENST00000444740.2
 CD79A

CD79a molecule, immunoglobulin-associated alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.2 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.7 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.5 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.8 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.3 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.1 0.6 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 0.3 GO:0000255 allantoin metabolic process(GO:0000255) cellular amide catabolic process(GO:0043605)
0.1 0.3 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.1 1.3 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.4 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.2 GO:0071321 cellular response to cGMP(GO:0071321)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.7 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.1 GO:1904481 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.0 0.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.6 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.1 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.6 GO:1990423 RZZ complex(GO:1990423)
0.1 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.3 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.2 GO:0033150 cytoskeletal calyx(GO:0033150)
0.1 0.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 1.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.1 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.4 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.1 0.2 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.3 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0047718 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.0 0.1 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.3 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.6 GO:0051400 BH domain binding(GO:0051400)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.1 GO:0070905 serine binding(GO:0070905)
0.0 0.0 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels