Motif ID: SOX3_SOX2

Z-value: 1.629

Transcription factors associated with SOX3_SOX2:

Gene SymbolEntrez IDGene Name
SOX2 ENSG00000181449.2 SOX2
SOX3 ENSG00000134595.6 SOX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX2hg19_v2_chr3_+_181429704_181429722-0.611.7e-03Click!
SOX3hg19_v2_chrX_-_139587225_1395872340.154.8e-01Click!


Activity profile for motif SOX3_SOX2.

activity profile for motif SOX3_SOX2


Sorted Z-values histogram for motif SOX3_SOX2

Sorted Z-values for motif SOX3_SOX2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX3_SOX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_1748214 6.543 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
 PXDN


peroxidasin homolog (Drosophila)


chr6_-_30654977 5.833 ENST00000399199.3
 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr1_-_205419053 4.118 ENST00000367154.1
 LEMD1
LEM domain containing 1
chr19_-_49864746 3.817 ENST00000598810.1
 TEAD2
TEA domain family member 2
chr1_-_153029980 3.721 ENST00000392653.2
 SPRR2A
small proline-rich protein 2A
chr10_-_105845674 3.719 ENST00000353479.5
ENST00000369733.3
 COL17A1

collagen, type XVII, alpha 1

chr19_-_51472823 3.531 ENST00000310157.2
 KLK6
kallikrein-related peptidase 6
chr15_-_74495188 3.280 ENST00000563965.1
ENST00000395105.4
 STRA6

stimulated by retinoic acid 6

chr4_-_80993717 3.198 ENST00000307333.7
 ANTXR2
anthrax toxin receptor 2
chr6_+_114178512 3.025 ENST00000368635.4
 MARCKS
myristoylated alanine-rich protein kinase C substrate
chr2_-_216257849 2.925 ENST00000456923.1
 FN1
fibronectin 1
chrX_-_38080077 2.676 ENST00000378533.3
ENST00000544439.1
ENST00000432886.2
ENST00000538295.1
 SRPX



sushi-repeat containing protein, X-linked



chr12_-_95611149 2.623 ENST00000549499.1
ENST00000343958.4
ENST00000546711.1
 FGD6


FYVE, RhoGEF and PH domain containing 6


chr1_-_205391178 2.556 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
 LEMD1



LEM domain containing 1



chr4_-_103266355 2.534 ENST00000424970.2
 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr5_+_137514687 2.515 ENST00000394894.3
 KIF20A
kinesin family member 20A
chr20_-_56284816 2.509 ENST00000395819.3
ENST00000341744.3
 PMEPA1

prostate transmembrane protein, androgen induced 1

chr5_+_137514834 2.440 ENST00000508792.1
ENST00000504621.1
 KIF20A

kinesin family member 20A

chr2_-_26205340 2.428 ENST00000264712.3
 KIF3C
kinesin family member 3C
chr6_+_64282447 2.427 ENST00000370650.2
ENST00000578299.1
 PTP4A1

protein tyrosine phosphatase type IVA, member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 512 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.5 GO:0018149 peptide cross-linking(GO:0018149)
0.1 8.3 GO:1901998 toxin transport(GO:1901998)
0.7 7.4 GO:0097070 ductus arteriosus closure(GO:0097070)
0.2 7.1 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.3 6.2 GO:0051764 actin crosslink formation(GO:0051764)
0.5 5.6 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.2 5.2 GO:0030903 notochord development(GO:0030903)
0.2 5.1 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 4.8 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.9 4.3 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
1.4 4.2 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.2 4.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 3.8 GO:0016540 protein autoprocessing(GO:0016540)
0.2 3.8 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.1 3.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.6 3.5 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.3 3.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 3.5 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
1.0 3.1 GO:1904298 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
0.1 3.1 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.7 GO:0001533 cornified envelope(GO:0001533)
0.0 8.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 8.1 GO:0005871 kinesin complex(GO:0005871)
0.3 7.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 6.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 5.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.2 GO:0070821 tertiary granule membrane(GO:0070821)
1.3 5.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 4.6 GO:0045120 pronucleus(GO:0045120)
0.0 4.6 GO:0005882 intermediate filament(GO:0005882)
0.3 4.2 GO:0030478 actin cap(GO:0030478)
0.0 3.8 GO:0000781 chromosome, telomeric region(GO:0000781)
0.2 3.7 GO:0030056 hemidesmosome(GO:0030056)
0.2 3.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 3.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.3 GO:0001726 ruffle(GO:0001726)
0.8 3.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 3.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.8 3.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 3.0 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 336 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 GO:0003777 microtubule motor activity(GO:0003777)
1.5 7.3 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 5.6 GO:0016504 peptidase activator activity(GO:0016504)
0.2 5.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 5.5 GO:0017124 SH3 domain binding(GO:0017124)
0.1 5.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 5.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 4.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 4.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 4.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 4.5 GO:0045499 chemorepellent activity(GO:0045499)
0.5 4.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 4.2 GO:0005080 protein kinase C binding(GO:0005080)
1.0 4.1 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.2 3.9 GO:0031005 filamin binding(GO:0031005)
0.1 3.9 GO:0070412 R-SMAD binding(GO:0070412)
0.6 3.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 3.5 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 3.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 8.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 6.7 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 4.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 4.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 4.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 4.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 4.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 4.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.3 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 4.2 PID_LKB1_PATHWAY LKB1 signaling events
0.0 4.0 PID_E2F_PATHWAY E2F transcription factor network
0.3 3.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.5 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 3.5 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 3.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 REACTOME_KINESINS Genes involved in Kinesins
0.1 8.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 6.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 5.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 5.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 5.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 3.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.6 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 3.6 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.2 3.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 3.5 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.3 3.0 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.8 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 2.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.5 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.1 2.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 2.3 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle