Motif ID: SOX4

Z-value: 0.654


Transcription factors associated with SOX4:

Gene SymbolEntrez IDGene Name
SOX4 ENSG00000124766.4 SOX4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX4hg19_v2_chr6_+_21593972_21594071-0.174.2e-01Click!


Activity profile for motif SOX4.

activity profile for motif SOX4


Sorted Z-values histogram for motif SOX4

Sorted Z-values for motif SOX4



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_74495188 1.754 ENST00000563965.1
ENST00000395105.4
 STRA6

stimulated by retinoic acid 6

chr10_-_105845674 1.748 ENST00000353479.5
ENST00000369733.3
 COL17A1

collagen, type XVII, alpha 1

chr14_+_75746781 1.644 ENST00000555347.1
 FOS
FBJ murine osteosarcoma viral oncogene homolog
chr2_-_208031542 1.413 ENST00000423015.1
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr7_+_134551583 1.342 ENST00000435928.1
 CALD1
caldesmon 1
chrX_-_153599578 1.275 ENST00000360319.4
ENST00000344736.4
 FLNA

filamin A, alpha

chr4_-_69111401 1.239 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr2_+_33172221 1.212 ENST00000354476.3
 LTBP1
latent transforming growth factor beta binding protein 1
chr22_+_31477296 1.192 ENST00000426927.1
ENST00000440425.1
ENST00000358743.1
ENST00000347557.2
ENST00000333137.7
 SMTN




smoothelin




chr15_+_63335899 1.128 ENST00000561266.1
 TPM1
tropomyosin 1 (alpha)
chr4_+_54966198 1.038 ENST00000326902.2
ENST00000503800.1
 GSX2

GS homeobox 2

chr2_-_1748214 1.008 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
 PXDN


peroxidasin homolog (Drosophila)


chrX_+_69509927 0.992 ENST00000374403.3
 KIF4A
kinesin family member 4A
chr2_-_85641162 0.969 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
 CAPG


capping protein (actin filament), gelsolin-like


chr2_-_9143786 0.940 ENST00000462696.1
ENST00000305997.3
 MBOAT2

membrane bound O-acyltransferase domain containing 2

chr7_+_134464376 0.921 ENST00000454108.1
ENST00000361675.2
 CALD1

caldesmon 1

chr7_-_107643674 0.918 ENST00000222399.6
 LAMB1
laminin, beta 1
chr7_+_134464414 0.907 ENST00000361901.2
 CALD1
caldesmon 1
chr11_-_10829851 0.827 ENST00000532082.1
 EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr11_+_125496619 0.764 ENST00000532669.1
ENST00000278916.3
 CHEK1

checkpoint kinase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.1 GO:1905031 regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905031)
0.2 1.9 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.4 1.8 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 1.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 1.6 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 1.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 1.3 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.3 1.2 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.3 1.2 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 1.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 1.1 GO:0070307 lens fiber cell development(GO:0070307)
0.1 1.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 1.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 1.0 GO:0006826 iron ion transport(GO:0006826)
0.2 0.9 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 0.9 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.9 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 0.8 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 0.8 GO:0044351 macropinocytosis(GO:0044351)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 GO:0030478 actin cap(GO:0030478)
0.1 1.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 1.8 GO:0043219 lateral loop(GO:0043219)
0.1 1.7 GO:0030056 hemidesmosome(GO:0030056)
0.2 1.6 GO:0035976 AP1 complex(GO:0035976)
0.1 1.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.4 1.3 GO:0031523 Myb complex(GO:0031523)
0.0 1.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.0 1.1 GO:1904115 axon cytoplasm(GO:1904115)
0.3 0.9 GO:0005607 laminin-2 complex(GO:0005607)
0.1 0.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.7 GO:0070852 cell body fiber(GO:0070852)
0.1 0.5 GO:0005638 lamin filament(GO:0005638)
0.0 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 2.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 1.9 GO:0050436 microfibril binding(GO:0050436)
0.2 1.8 GO:0097016 L27 domain binding(GO:0097016)
0.0 1.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 1.3 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 1.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 1.0 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 1.0 GO:0017022 myosin binding(GO:0017022)
0.1 0.9 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.1 0.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 0.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.3 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.0 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.0 0.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.8 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME_DEFENSINS Genes involved in Defensins
0.0 0.6 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.0 0.5 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA