Motif ID: SOX5

Z-value: 1.129


Transcription factors associated with SOX5:

Gene SymbolEntrez IDGene Name
SOX5 ENSG00000134532.11 SOX5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX5hg19_v2_chr12_-_24103954_241039720.174.2e-01Click!


Activity profile for motif SOX5.

activity profile for motif SOX5


Sorted Z-values histogram for motif SOX5

Sorted Z-values for motif SOX5



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_165675197 4.377 ENST00000515485.1
 RP11-294O2.2
RP11-294O2.2
chr6_-_32557610 4.321 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr7_-_16921601 4.224 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
 AGR3


anterior gradient 3


chr19_+_55888186 3.799 ENST00000291934.3
 TMEM190
transmembrane protein 190
chr15_+_71228826 3.670 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
 LRRC49




leucine rich repeat containing 49




chr4_+_165675269 3.576 ENST00000507311.1
 RP11-294O2.2
RP11-294O2.2
chr3_-_19988462 3.395 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr20_-_3762087 3.309 ENST00000379756.3
 SPEF1
sperm flagellar 1
chr3_+_181429704 3.241 ENST00000431565.2
ENST00000325404.1
 SOX2

SRY (sex determining region Y)-box 2

chr14_-_92413727 2.882 ENST00000267620.10
 FBLN5
fibulin 5
chr1_-_36906474 2.836 ENST00000433045.2
 OSCP1
organic solute carrier partner 1
chr7_-_131241361 2.708 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
 PODXL



podocalyxin-like



chrY_+_15016013 2.583 ENST00000360160.4
ENST00000454054.1
 DDX3Y

DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked

chr4_-_105416039 2.409 ENST00000394767.2
 CXXC4
CXXC finger protein 4
chr11_+_36397528 2.372 ENST00000311599.5
ENST00000378867.3
 PRR5L

proline rich 5 like

chrX_-_117107542 2.365 ENST00000371878.1
 KLHL13
kelch-like family member 13
chr4_+_25657444 2.302 ENST00000504570.1
ENST00000382051.3
 SLC34A2

solute carrier family 34 (type II sodium/phosphate contransporter), member 2

chr1_-_40367668 2.221 ENST00000397332.2
ENST00000429311.1
 MYCL

v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog

chr2_-_157198860 2.060 ENST00000409572.1
 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr6_-_9939552 1.928 ENST00000460363.2
 OFCC1
orofacial cleft 1 candidate 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.6 GO:0048251 elastic fiber assembly(GO:0048251)
0.9 4.3 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.5 4.3 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 4.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 4.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 3.6 GO:0000910 cytokinesis(GO:0000910)
0.2 3.4 GO:0038203 TORC2 signaling(GO:0038203)
0.1 3.4 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.2 3.2 GO:0021781 glial cell fate commitment(GO:0021781)
0.5 2.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.7 2.7 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.3 2.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 2.6 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 2.3 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.7 2.1 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 1.9 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 1.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.5 1.8 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0032993 protein-DNA complex(GO:0032993)
0.6 5.6 GO:0071953 elastic fiber(GO:0071953)
0.2 4.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 4.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.8 3.8 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 3.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 3.1 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.3 2.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.3 GO:0031526 brush border membrane(GO:0031526)
0.1 1.7 GO:0097512 cardiac myofibril(GO:0097512)
0.5 1.6 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.0 1.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 1.2 GO:0001725 stress fiber(GO:0001725) actin filament bundle(GO:0032432) contractile actin filament bundle(GO:0097517)
0.2 1.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.1 GO:0035580 specific granule lumen(GO:0035580)
0.1 1.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 1.0 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 4.4 GO:0043621 protein self-association(GO:0043621)
0.1 4.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 4.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 4.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 4.0 GO:0030165 PDZ domain binding(GO:0030165)
0.2 3.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 3.2 GO:0035198 miRNA binding(GO:0035198)
0.2 2.3 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.1 2.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.7 GO:0051087 chaperone binding(GO:0051087)
0.5 1.6 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.2 1.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.1 GO:0031013 troponin I binding(GO:0031013)
0.0 1.1 GO:0050681 androgen receptor binding(GO:0050681)
0.3 1.0 GO:0004948 calcitonin receptor activity(GO:0004948)
0.2 1.0 GO:0035939 microsatellite binding(GO:0035939)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 4.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 4.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 4.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 3.4 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 3.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.2 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.0 1.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 0.9 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 0.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.6 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_OPSINS Genes involved in Opsins