Motif ID: SOX6

Z-value: 0.505


Transcription factors associated with SOX6:

Gene SymbolEntrez IDGene Name
SOX6 ENSG00000110693.11 SOX6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX6hg19_v2_chr11_-_16430399_16430440-0.232.7e-01Click!


Activity profile for motif SOX6.

activity profile for motif SOX6


Sorted Z-values histogram for motif SOX6

Sorted Z-values for motif SOX6



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_180018540 2.388 ENST00000292641.3
 SCGB3A1
secretoglobin, family 3A, member 1
chr4_+_70861647 1.763 ENST00000246895.4
ENST00000381060.2
 STATH

statherin

chr16_+_23765948 1.547 ENST00000300113.2
 CHP2
calcineurin-like EF-hand protein 2
chr20_-_39317868 1.350 ENST00000373313.2
 MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr10_+_115511213 1.291 ENST00000361048.1
 PLEKHS1
pleckstrin homology domain containing, family S member 1
chr5_+_140213815 1.228 ENST00000525929.1
ENST00000378125.3
 PCDHA7

protocadherin alpha 7

chr5_+_140254884 1.015 ENST00000398631.2
 PCDHA12
protocadherin alpha 12
chr14_-_106926724 1.003 ENST00000434710.1
 IGHV3-43
immunoglobulin heavy variable 3-43
chr2_-_86564776 0.983 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
 REEP1


receptor accessory protein 1


chr6_-_29527702 0.980 ENST00000377050.4
 UBD
ubiquitin D
chr12_-_49582978 0.926 ENST00000301071.7
 TUBA1A
tubulin, alpha 1a
chr13_+_24144796 0.909 ENST00000403372.2
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr13_+_24144509 0.861 ENST00000248484.4
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr4_+_41614909 0.811 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
 LIMCH1


LIM and calponin homology domains 1


chr6_-_139613269 0.760 ENST00000358430.3
 TXLNB
taxilin beta
chr3_+_181429704 0.705 ENST00000431565.2
ENST00000325404.1
 SOX2

SRY (sex determining region Y)-box 2

chr5_+_140235469 0.696 ENST00000506939.2
ENST00000307360.5
 PCDHA10

protocadherin alpha 10

chr4_+_55524085 0.659 ENST00000412167.2
ENST00000288135.5
 KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr2_-_217560248 0.632 ENST00000233813.4
 IGFBP5
insulin-like growth factor binding protein 5
chr18_+_6729698 0.615 ENST00000383472.4
 ARHGAP28
Rho GTPase activating protein 28

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.4 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 1.8 GO:0046541 saliva secretion(GO:0046541)
0.0 1.7 GO:0001942 hair follicle development(GO:0001942)
0.1 1.5 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.4 1.3 GO:0035283 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.2 1.0 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.9 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.8 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.2 0.7 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.1 0.7 GO:0001714 endodermal cell fate specification(GO:0001714)
0.1 0.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 0.6 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.2 0.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.6 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.6 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.2 0.5 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.5 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 0.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.2 0.6 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.8 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 1.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 1.0 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.7 GO:0035198 miRNA binding(GO:0035198)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.6 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.5 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.0 0.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.5 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.4 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.4 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.1 0.3 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT
0.0 0.2 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide