Motif ID: SOX8

Z-value: 0.766


Transcription factors associated with SOX8:

Gene SymbolEntrez IDGene Name
SOX8 ENSG00000005513.9 SOX8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX8hg19_v2_chr16_+_1031762_1031808-0.029.2e-01Click!


Activity profile for motif SOX8.

activity profile for motif SOX8


Sorted Z-values histogram for motif SOX8

Sorted Z-values for motif SOX8



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_160279207 2.268 ENST00000327245.5
 ATP10B
ATPase, class V, type 10B
chr6_-_52668605 2.086 ENST00000334575.5
 GSTA1
glutathione S-transferase alpha 1
chr6_-_32498046 2.034 ENST00000374975.3
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr4_-_100356551 2.008 ENST00000209665.4
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr6_+_32605195 1.820 ENST00000374949.2
 HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr12_-_10282836 1.745 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
 CLEC7A


C-type lectin domain family 7, member A


chr2_+_26624775 1.632 ENST00000288710.2
 DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr4_-_100356291 1.533 ENST00000476959.1
ENST00000482593.1
 ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr14_-_106642049 1.479 ENST00000390605.2
 IGHV1-18
immunoglobulin heavy variable 1-18
chr13_+_43355683 1.459 ENST00000537894.1
 FAM216B
family with sequence similarity 216, member B
chr12_-_71551652 1.380 ENST00000546561.1
 TSPAN8
tetraspanin 8
chr5_+_140227048 1.302 ENST00000532602.1
 PCDHA9
protocadherin alpha 9
chr1_+_12806141 1.278 ENST00000288048.5
 C1orf158
chromosome 1 open reading frame 158
chr12_-_10282742 1.271 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A


C-type lectin domain family 7, member A


chr7_+_48494660 1.223 ENST00000411975.1
ENST00000544596.1
 ABCA13

ATP-binding cassette, sub-family A (ABC1), member 13

chr12_-_10282681 1.207 ENST00000533022.1
 CLEC7A
C-type lectin domain family 7, member A
chr5_+_140602904 1.205 ENST00000515856.2
ENST00000239449.4
 PCDHB14

protocadherin beta 14

chr3_-_193272741 1.026 ENST00000392443.3
 ATP13A4
ATPase type 13A4
chr5_+_140186647 1.018 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
 PCDHA4


protocadherin alpha 4


chr16_+_57392684 0.939 ENST00000219235.4
 CCL22
chemokine (C-C motif) ligand 22

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.2 4.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
1.2 3.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 2.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.8 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 1.6 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.0 1.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.4 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 1.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 1.0 GO:0006174 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.1 0.9 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.9 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 0.8 GO:1901318 negative regulation of sperm motility(GO:1901318)
0.1 0.8 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.8 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.7 GO:0070269 pyroptosis(GO:0070269)
0.0 0.7 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.8 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.7 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.7 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.5 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.1 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.3 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.9 3.5 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 2.6 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 2.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 2.0 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 1.6 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 1.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 1.0 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.1 1.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.9 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 0.8 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.7 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 3.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 2.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 2.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.4 REACTOME_OPSINS Genes involved in Opsins
0.0 1.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.5 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol