Motif ID: SOX8

Z-value: 0.766


Transcription factors associated with SOX8:

Gene SymbolEntrez IDGene Name
SOX8 ENSG00000005513.9 SOX8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX8hg19_v2_chr16_+_1031762_1031808-0.029.2e-01Click!


Activity profile for motif SOX8.

activity profile for motif SOX8


Sorted Z-values histogram for motif SOX8

Sorted Z-values for motif SOX8



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_160279207 2.268 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr6_-_52668605 2.086 ENST00000334575.5
GSTA1
glutathione S-transferase alpha 1
chr6_-_32498046 2.034 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr4_-_100356551 2.008 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr6_+_32605195 1.820 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr12_-_10282836 1.745 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A


C-type lectin domain family 7, member A


chr2_+_26624775 1.632 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr4_-_100356291 1.533 ENST00000476959.1
ENST00000482593.1
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr14_-_106642049 1.479 ENST00000390605.2
IGHV1-18
immunoglobulin heavy variable 1-18
chr13_+_43355683 1.459 ENST00000537894.1
FAM216B
family with sequence similarity 216, member B
chr12_-_71551652 1.380 ENST00000546561.1
TSPAN8
tetraspanin 8
chr5_+_140227048 1.302 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr1_+_12806141 1.278 ENST00000288048.5
C1orf158
chromosome 1 open reading frame 158
chr12_-_10282742 1.271 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A


C-type lectin domain family 7, member A


chr7_+_48494660 1.223 ENST00000411975.1
ENST00000544596.1
ABCA13

ATP-binding cassette, sub-family A (ABC1), member 13

chr12_-_10282681 1.207 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr5_+_140602904 1.205 ENST00000515856.2
ENST00000239449.4
PCDHB14

protocadherin beta 14

chr3_-_193272741 1.026 ENST00000392443.3
ATP13A4
ATPase type 13A4
chr5_+_140186647 1.018 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4


protocadherin alpha 4


chr16_+_57392684 0.939 ENST00000219235.4
CCL22
chemokine (C-C motif) ligand 22
chr16_+_618837 0.913 ENST00000409439.2
PIGQ
phosphatidylinositol glycan anchor biosynthesis, class Q
chr2_+_233527443 0.825 ENST00000410095.1
EFHD1
EF-hand domain family, member D1
chr16_+_82068830 0.823 ENST00000199936.4
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr15_-_65715401 0.815 ENST00000352385.2
IGDCC4
immunoglobulin superfamily, DCC subclass, member 4
chr6_+_32605134 0.801 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1


major histocompatibility complex, class II, DQ alpha 1


chr2_-_32489922 0.721 ENST00000402280.1
NLRC4
NLR family, CARD domain containing 4
chr12_-_39837192 0.716 ENST00000361961.3
ENST00000395670.3
KIF21A

kinesin family member 21A

chr10_+_88414338 0.704 ENST00000241891.5
ENST00000443292.1
OPN4

opsin 4

chr10_+_88414298 0.678 ENST00000372071.2
OPN4
opsin 4
chr6_-_52710893 0.666 ENST00000284562.2
GSTA5
glutathione S-transferase alpha 5
chr12_+_21207503 0.658 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr10_+_7745232 0.641 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr14_+_22580233 0.617 ENST00000390454.2
TRAV25
T cell receptor alpha variable 25
chr5_-_179499108 0.609 ENST00000521389.1
RNF130
ring finger protein 130
chr5_-_179499086 0.594 ENST00000261947.4
RNF130
ring finger protein 130
chr19_-_45681482 0.583 ENST00000592647.1
ENST00000006275.4
ENST00000588062.1
ENST00000585934.1
TRAPPC6A



trafficking protein particle complex 6A



chr12_-_15104040 0.556 ENST00000541644.1
ENST00000545895.1
ARHGDIB

Rho GDP dissociation inhibitor (GDI) beta

chr4_+_89299994 0.541 ENST00000264346.7
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr13_+_97928395 0.533 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr2_-_175711133 0.528 ENST00000409597.1
ENST00000413882.1
CHN1

chimerin 1

chrX_-_151999269 0.515 ENST00000370277.3
CETN2
centrin, EF-hand protein, 2
chr18_-_5396271 0.503 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr6_-_110011704 0.497 ENST00000448084.2
AK9
adenylate kinase 9
chr18_-_53253112 0.495 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
TCF4


transcription factor 4


chr2_-_28113965 0.490 ENST00000302188.3
RBKS
ribokinase
chr18_-_53253323 0.489 ENST00000540999.1
ENST00000563888.2
TCF4

transcription factor 4

chr4_-_75695366 0.488 ENST00000512743.1
BTC
betacellulin
chr4_-_70518941 0.482 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr1_+_13516066 0.482 ENST00000332192.6
PRAMEF21
PRAME family member 21
chr6_-_110011718 0.481 ENST00000532976.1
AK9
adenylate kinase 9
chr21_-_43735628 0.479 ENST00000291525.10
ENST00000518498.1
TFF3

trefoil factor 3 (intestinal)

chr16_+_21244986 0.464 ENST00000311620.5
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr6_-_150217195 0.459 ENST00000532335.1
RAET1E
retinoic acid early transcript 1E
chr10_-_49482907 0.450 ENST00000374201.3
ENST00000407470.4
FRMPD2

FERM and PDZ domain containing 2

chr8_+_21915368 0.450 ENST00000265800.5
ENST00000517418.1
DMTN

dematin actin binding protein

chr10_-_1779663 0.444 ENST00000381312.1
ADARB2
adenosine deaminase, RNA-specific, B2 (non-functional)
chr1_-_48937838 0.443 ENST00000371847.3
SPATA6
spermatogenesis associated 6
chr17_-_34313685 0.434 ENST00000435911.2
ENST00000586216.1
ENST00000394509.4
CCL14


chemokine (C-C motif) ligand 14


chr16_+_53241854 0.426 ENST00000565803.1
CHD9
chromodomain helicase DNA binding protein 9
chr17_+_2240916 0.425 ENST00000574563.1
SGSM2
small G protein signaling modulator 2
chr16_+_57769635 0.423 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
KATNB1


katanin p80 (WD repeat containing) subunit B 1


chr6_+_80129989 0.419 ENST00000429444.1
RP1-232L24.3
RP1-232L24.3
chr2_-_159237472 0.418 ENST00000409187.1
CCDC148
coiled-coil domain containing 148
chr1_+_110577229 0.410 ENST00000369795.3
ENST00000369794.2
STRIP1

striatin interacting protein 1

chr20_+_48807351 0.410 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr17_-_7145475 0.409 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABARAP


GABA(A) receptor-associated protein


chr3_-_129147432 0.406 ENST00000503957.1
ENST00000505956.1
ENST00000326085.3
EFCAB12


EF-hand calcium binding domain 12


chr2_+_204801471 0.403 ENST00000316386.6
ENST00000435193.1
ICOS

inducible T-cell co-stimulator

chr20_-_44176060 0.403 ENST00000354280.4
ENST00000504988.1
EPPIN
EPPIN-WFDC6
epididymal peptidase inhibitor
EPPIN-WFDC6 readthrough
chr20_-_44176013 0.402 ENST00000555685.1
EPPIN
epididymal peptidase inhibitor
chr3_-_49851313 0.396 ENST00000333486.3
UBA7
ubiquitin-like modifier activating enzyme 7
chr3_-_165555200 0.390 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE



butyrylcholinesterase



chr17_-_19648683 0.386 ENST00000573368.1
ENST00000457500.2
ALDH3A1

aldehyde dehydrogenase 3 family, member A1

chr18_+_61575200 0.380 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr16_+_22308717 0.378 ENST00000299853.5
ENST00000564209.1
ENST00000565358.1
ENST00000418581.2
ENST00000564883.1
ENST00000359210.4
ENST00000563024.1
POLR3E






polymerase (RNA) III (DNA directed) polypeptide E (80kD)






chr18_-_77711625 0.374 ENST00000357575.4
ENST00000590381.1
ENST00000397778.2
PQLC1


PQ loop repeat containing 1


chr1_+_112016414 0.373 ENST00000343534.5
ENST00000369718.3
C1orf162

chromosome 1 open reading frame 162

chr4_-_69111401 0.368 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr22_-_42466782 0.366 ENST00000396398.3
ENST00000403363.1
ENST00000402937.1
NAGA


N-acetylgalactosaminidase, alpha-


chr6_-_49712147 0.364 ENST00000433368.2
ENST00000354620.4
CRISP3

cysteine-rich secretory protein 3

chr13_+_108922228 0.362 ENST00000542136.1
TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr4_-_141348999 0.359 ENST00000325617.5
CLGN
calmegin
chr3_-_146213722 0.359 ENST00000336685.2
ENST00000489015.1
PLSCR2

phospholipid scramblase 2

chr3_+_137906109 0.356 ENST00000481646.1
ENST00000469044.1
ENST00000491704.1
ENST00000461600.1
ARMC8



armadillo repeat containing 8



chr17_-_38938786 0.354 ENST00000301656.3
KRT27
keratin 27
chr7_+_64126535 0.350 ENST00000344930.3
ZNF107
zinc finger protein 107
chr19_+_1269324 0.339 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP










cold inducible RNA binding protein










chr12_-_9760482 0.336 ENST00000229402.3
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chrX_-_132887729 0.333 ENST00000406757.2
GPC3
glypican 3
chr8_-_11873043 0.333 ENST00000527396.1
RP11-481A20.11
Protein LOC101060662
chr11_-_77791156 0.331 ENST00000281031.4
NDUFC2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
chr15_+_34261089 0.331 ENST00000383263.5
CHRM5
cholinergic receptor, muscarinic 5
chr6_-_49712123 0.330 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr3_-_186288097 0.327 ENST00000446782.1
TBCCD1
TBCC domain containing 1
chr2_+_219646462 0.324 ENST00000258415.4
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr12_-_15103621 0.324 ENST00000536592.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_+_170550944 0.323 ENST00000359744.3
ENST00000438838.1
ENST00000438710.1
ENST00000449906.1
ENST00000498202.2
ENST00000272797.4
PHOSPHO2



KLHL23

phosphatase, orphan 2



kelch-like family member 23

chr1_+_231114795 0.319 ENST00000310256.2
ENST00000366658.2
ENST00000450711.1
ENST00000435927.1
ARV1



ARV1 homolog (S. cerevisiae)



chr7_+_80275752 0.310 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chr14_+_95078714 0.307 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3


serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3


chr12_-_8693469 0.306 ENST00000545274.1
ENST00000446457.2
CLEC4E

C-type lectin domain family 4, member E

chr1_-_67142710 0.302 ENST00000502413.2
AL139147.1
Uncharacterized protein
chr2_-_170550877 0.297 ENST00000447353.1
CCDC173
coiled-coil domain containing 173
chr12_-_10151773 0.294 ENST00000298527.6
ENST00000348658.4
CLEC1B

C-type lectin domain family 1, member B

chr3_+_38347427 0.292 ENST00000273173.4
SLC22A14
solute carrier family 22, member 14
chr15_+_43885252 0.291 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B



creatine kinase, mitochondrial 1B



chr20_+_32150140 0.287 ENST00000344201.3
ENST00000346541.3
ENST00000397800.1
ENST00000397798.2
ENST00000492345.1
CBFA2T2




core-binding factor, runt domain, alpha subunit 2; translocated to, 2




chr17_+_41132564 0.287 ENST00000361677.1
ENST00000589705.1
RUNDC1

RUN domain containing 1

chr7_-_92855762 0.283 ENST00000453812.2
ENST00000394468.2
HEPACAM2

HEPACAM family member 2

chr9_-_130661916 0.283 ENST00000373142.1
ENST00000373146.1
ENST00000373144.3
ST6GALNAC6


ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6


chr12_-_100660833 0.282 ENST00000551642.1
ENST00000416321.1
ENST00000550587.1
ENST00000549249.1
DEPDC4



DEP domain containing 4



chr15_+_43985084 0.282 ENST00000434505.1
ENST00000411750.1
CKMT1A

creatine kinase, mitochondrial 1A

chr17_-_47723943 0.277 ENST00000510476.1
ENST00000503676.1
SPOP

speckle-type POZ protein

chr2_-_207024233 0.277 ENST00000423725.1
ENST00000233190.6
NDUFS1

NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

chr6_-_31689456 0.274 ENST00000495859.1
ENST00000375819.2
LY6G6C

lymphocyte antigen 6 complex, locus G6C

chr12_-_8693539 0.274 ENST00000299663.3
CLEC4E
C-type lectin domain family 4, member E
chr3_+_185080908 0.273 ENST00000265026.3
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr6_-_76072719 0.265 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr4_-_122854193 0.265 ENST00000513531.1
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr19_-_37697976 0.259 ENST00000588873.1
CTC-454I21.3
Uncharacterized protein; Zinc finger protein 585B
chr8_+_1993173 0.258 ENST00000523438.1
MYOM2
myomesin 2
chr19_-_8213753 0.258 ENST00000601739.1
FBN3
fibrillin 3
chr16_+_31271274 0.252 ENST00000287497.8
ENST00000544665.3
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr8_+_1993152 0.252 ENST00000262113.4
MYOM2
myomesin 2
chr15_-_89755034 0.249 ENST00000563254.1
RLBP1
retinaldehyde binding protein 1
chr10_-_87551311 0.249 ENST00000536331.1
GRID1
glutamate receptor, ionotropic, delta 1
chr7_+_79998864 0.248 ENST00000435819.1
CD36
CD36 molecule (thrombospondin receptor)
chr6_-_32160622 0.241 ENST00000487761.1
ENST00000375040.3
GPSM3

G-protein signaling modulator 3

chr1_-_231005310 0.239 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr9_+_2157655 0.236 ENST00000452193.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_-_20040638 0.235 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
SLC18A1



solute carrier family 18 (vesicular monoamine transporter), member 1



chr5_+_118965244 0.235 ENST00000515256.1
ENST00000509264.1
FAM170A

family with sequence similarity 170, member A

chr9_-_130533615 0.231 ENST00000373277.4
SH2D3C
SH2 domain containing 3C
chr16_-_90096309 0.226 ENST00000408886.2
C16orf3
chromosome 16 open reading frame 3
chr7_+_80275621 0.225 ENST00000426978.1
ENST00000432207.1
CD36

CD36 molecule (thrombospondin receptor)

chr19_+_19144384 0.223 ENST00000392335.2
ENST00000535612.1
ENST00000537263.1
ENST00000540707.1
ENST00000541725.1
ENST00000269932.6
ENST00000546344.1
ENST00000540792.1
ENST00000536098.1
ENST00000541898.1
ENST00000543877.1
ARMC6










armadillo repeat containing 6










chr17_-_43339474 0.223 ENST00000331780.4
SPATA32
spermatogenesis associated 32
chr3_+_157154578 0.222 ENST00000295927.3
PTX3
pentraxin 3, long
chr17_+_34087888 0.220 ENST00000586491.1
ENST00000588628.1
ENST00000285023.4
C17orf50


chromosome 17 open reading frame 50


chr6_-_159421198 0.219 ENST00000252655.1
ENST00000297262.3
ENST00000367069.2
RSPH3


radial spoke 3 homolog (Chlamydomonas)


chrX_-_117107542 0.217 ENST00000371878.1
KLHL13
kelch-like family member 13
chr12_+_14927270 0.212 ENST00000544848.1
H2AFJ
H2A histone family, member J
chr12_-_57443886 0.210 ENST00000300119.3
MYO1A
myosin IA
chr2_+_97203082 0.210 ENST00000454558.2
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr1_-_48937821 0.209 ENST00000396199.3
SPATA6
spermatogenesis associated 6
chr3_+_154958715 0.209 ENST00000462531.1
ENST00000490497.1
RP11-451G4.1

RP11-451G4.1

chr11_+_10477733 0.209 ENST00000528723.1
AMPD3
adenosine monophosphate deaminase 3
chr22_-_50708781 0.207 ENST00000449719.2
ENST00000330651.6
MAPK11

mitogen-activated protein kinase 11

chr14_-_106471723 0.205 ENST00000390595.2
IGHV1-3
immunoglobulin heavy variable 1-3
chr1_-_85930246 0.204 ENST00000426972.3
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr4_+_86525299 0.201 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr17_-_43339453 0.199 ENST00000543122.1
SPATA32
spermatogenesis associated 32
chr3_+_142342228 0.199 ENST00000337777.3
PLS1
plastin 1
chr11_-_129062093 0.198 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr20_-_5426332 0.196 ENST00000420529.1
LINC00658
long intergenic non-protein coding RNA 658
chr3_+_35683651 0.196 ENST00000187397.4
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr19_+_1524072 0.195 ENST00000454744.2
PLK5
polo-like kinase 5
chr1_-_112106578 0.193 ENST00000369717.4
ADORA3
adenosine A3 receptor
chr7_-_27169801 0.192 ENST00000511914.1
HOXA4
homeobox A4
chr3_-_54962100 0.192 ENST00000273286.5
LRTM1
leucine-rich repeats and transmembrane domains 1
chr11_+_57435219 0.191 ENST00000527985.1
ENST00000287169.3
ZDHHC5

zinc finger, DHHC-type containing 5

chr17_-_34207295 0.188 ENST00000463941.1
ENST00000293272.3
CCL5

chemokine (C-C motif) ligand 5

chr6_+_147527103 0.188 ENST00000179882.6
STXBP5
syntaxin binding protein 5 (tomosyn)
chr3_-_187455680 0.185 ENST00000438077.1
BCL6
B-cell CLL/lymphoma 6
chrX_-_117107680 0.184 ENST00000447671.2
ENST00000262820.3
KLHL13

kelch-like family member 13

chr15_-_31283618 0.183 ENST00000563714.1
MTMR10
myotubularin related protein 10
chr17_-_66597530 0.183 ENST00000592554.1
FAM20A
family with sequence similarity 20, member A
chr7_-_38289173 0.182 ENST00000436911.2
TRGC2
T cell receptor gamma constant 2
chr7_-_32529973 0.181 ENST00000410044.1
ENST00000409987.1
ENST00000409782.1
ENST00000450169.2
LSM5



LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)



chr16_+_30387141 0.179 ENST00000566955.1
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr15_+_62853562 0.177 ENST00000561311.1
TLN2
talin 2
chr1_+_13742808 0.177 ENST00000602960.1
PRAMEF20
PRAME family member 20
chr10_-_36813162 0.171 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr12_+_133066137 0.170 ENST00000434748.2
FBRSL1
fibrosin-like 1
chr10_+_53806501 0.170 ENST00000373975.2
PRKG1
protein kinase, cGMP-dependent, type I
chr12_-_50101003 0.168 ENST00000550488.1
FMNL3
formin-like 3
chr4_-_10686475 0.165 ENST00000226951.6
CLNK
cytokine-dependent hematopoietic cell linker
chr19_-_37663332 0.157 ENST00000392157.2
ZNF585A
zinc finger protein 585A
chr16_-_28503357 0.155 ENST00000333496.9
ENST00000561505.1
ENST00000567963.1
ENST00000354630.5
ENST00000355477.5
ENST00000357076.5
ENST00000565688.1
ENST00000359984.7
CLN3







ceroid-lipofuscinosis, neuronal 3







chr11_-_96076334 0.154 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr3_+_148545586 0.153 ENST00000282957.4
ENST00000468341.1
CPB1

carboxypeptidase B1 (tissue)

chr14_+_22573582 0.151 ENST00000390453.1
TRAV24
T cell receptor alpha variable 24
chr17_-_8021710 0.150 ENST00000380149.1
ENST00000448843.2
ALOXE3

arachidonate lipoxygenase 3

chr8_+_107738240 0.150 ENST00000449762.2
ENST00000297447.6
OXR1

oxidation resistance 1

chr15_-_72563585 0.150 ENST00000287196.9
ENST00000260376.7
PARP6

poly (ADP-ribose) polymerase family, member 6

chr2_-_120124258 0.147 ENST00000409877.1
ENST00000409523.1
ENST00000409466.2
ENST00000414534.1
C2orf76



chromosome 2 open reading frame 76



chr1_+_26496362 0.146 ENST00000374266.5
ENST00000270812.5
ZNF593

zinc finger protein 593

chr4_+_40192656 0.146 ENST00000505618.1
RHOH
ras homolog family member H
chr3_-_49459878 0.143 ENST00000546031.1
ENST00000458307.2
ENST00000430521.1
AMT


aminomethyltransferase


chr3_-_21792838 0.139 ENST00000281523.2
ZNF385D
zinc finger protein 385D
chr1_+_161475208 0.139 ENST00000367972.4
ENST00000271450.6
FCGR2A

Fc fragment of IgG, low affinity IIa, receptor (CD32)

chr3_+_186288454 0.136 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr1_+_200993071 0.135 ENST00000446333.1
ENST00000458003.1
RP11-168O16.1

RP11-168O16.1

chr19_-_6333614 0.132 ENST00000301452.4
ACER1
alkaline ceramidase 1
chr15_-_78369994 0.131 ENST00000300584.3
ENST00000409931.3
TBC1D2B

TBC1 domain family, member 2B

chr15_+_72410629 0.131 ENST00000340912.4
ENST00000544171.1
SENP8

SUMO/sentrin specific peptidase family member 8

chr14_+_52327350 0.131 ENST00000555472.1
ENST00000556766.1
GNG2

guanine nucleotide binding protein (G protein), gamma 2

chr14_+_22337014 0.128 ENST00000390436.2
TRAV13-1
T cell receptor alpha variable 13-1
chr1_+_153631130 0.127 ENST00000368685.5
SNAPIN
SNAP-associated protein
chr3_-_49459865 0.127 ENST00000427987.1
AMT
aminomethyltransferase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.3 1.0 GO:0006174 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.2 4.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.2 0.5 GO:1904106 protein localization to microvillus(GO:1904106)
0.1 0.4 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.9 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.8 GO:1901318 negative regulation of sperm motility(GO:1901318)
0.1 0.8 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.4 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 0.5 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 0.6 GO:1903232 melanosome assembly(GO:1903232)
0.1 1.8 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 2.3 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.4 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 0.7 GO:0070269 pyroptosis(GO:0070269)
0.1 1.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.3 GO:0031296 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.1 1.6 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.1 0.5 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.5 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.2 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.1 0.2 GO:0044691 tooth eruption(GO:0044691)
0.1 0.3 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.1 0.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.3 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.2 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0 0.8 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.3 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.3 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.1 GO:1902824 positive regulation of late endosome to lysosome transport(GO:1902824)
0.0 0.1 GO:0001694 histamine biosynthetic process(GO:0001694)
0.0 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.2 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.5 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.9 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.2 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.4 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.2 GO:0006196 AMP catabolic process(GO:0006196)
0.0 0.2 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
0.0 4.5 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.4 GO:0097035 regulation of membrane lipid distribution(GO:0097035)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.1 GO:0010446 response to alkaline pH(GO:0010446)
0.0 1.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 1.4 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.1 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.0 0.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.5 GO:0035810 positive regulation of urine volume(GO:0035810)
0.0 0.1 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.0 0.1 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.7 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0019566 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:1900738 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.5 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.0 0.0 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.3 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.2 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.2 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.0 GO:0097360 chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.4 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.0 0.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.5 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 0.3 GO:0030220 platelet formation(GO:0030220)
0.0 0.1 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 0.7 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.7 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.1 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.8 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.3 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 1.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.2 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.5 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 1.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.3 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 1.6 GO:0005502 11-cis retinal binding(GO:0005502)
0.2 0.8 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.2 2.6 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 5.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.5 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 1.0 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.1 0.4 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 2.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.3 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.1 0.2 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.4 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.9 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 1.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.3 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.1 0.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 2.0 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.7 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0031177 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 1.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.4 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 1.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.0 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.0 0.1 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.0 0.3 GO:0001851 complement component C3b binding(GO:0001851)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.5 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 0.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.5 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0016929 SUMO-specific protease activity(GO:0016929) NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.0 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 4.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.4 REACTOME_OPSINS Genes involved in Opsins
0.1 2.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 2.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.9 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.7 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol