Motif ID: SOX9

Z-value: 0.602


Transcription factors associated with SOX9:

Gene SymbolEntrez IDGene Name
SOX9 ENSG00000125398.5 SOX9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX9hg19_v2_chr17_+_70117153_701171740.184.1e-01Click!


Activity profile for motif SOX9.

activity profile for motif SOX9


Sorted Z-values histogram for motif SOX9

Sorted Z-values for motif SOX9



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_124989804 1.006 ENST00000373755.2
ENST00000373754.2
 LHX6

LIM homeobox 6

chr1_-_26232951 0.864 ENST00000426559.2
ENST00000455785.2
 STMN1

stathmin 1

chr1_-_26232522 0.860 ENST00000399728.1
 STMN1
stathmin 1
chr10_+_102106829 0.756 ENST00000370355.2
 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr5_-_146833485 0.729 ENST00000398514.3
 DPYSL3
dihydropyrimidinase-like 3
chr7_+_155090271 0.587 ENST00000476756.1
 INSIG1
insulin induced gene 1
chr8_+_26435359 0.579 ENST00000311151.5
 DPYSL2
dihydropyrimidinase-like 2
chr3_-_46904946 0.572 ENST00000292327.4
 MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr3_-_46904918 0.571 ENST00000395869.1
 MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr1_-_173991434 0.570 ENST00000367696.2
 RC3H1
ring finger and CCCH-type domains 1
chr5_-_43313574 0.543 ENST00000325110.6
ENST00000433297.2
 HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr2_+_10262857 0.532 ENST00000304567.5
 RRM2
ribonucleotide reductase M2
chr17_+_75447326 0.531 ENST00000591088.1
 SEPT9
septin 9
chr9_+_80912059 0.527 ENST00000347159.2
ENST00000376588.3
 PSAT1

phosphoserine aminotransferase 1

chr5_-_16936340 0.513 ENST00000507288.1
ENST00000513610.1
 MYO10

myosin X

chr5_-_146833222 0.507 ENST00000534907.1
 DPYSL3
dihydropyrimidinase-like 3
chr12_-_95945246 0.483 ENST00000258499.3
 USP44
ubiquitin specific peptidase 44
chr16_+_15528332 0.442 ENST00000566490.1
 C16orf45
chromosome 16 open reading frame 45
chr19_+_58514229 0.438 ENST00000546949.1
ENST00000553254.1
ENST00000547364.1
 CTD-2368P22.1


HCG1811579; Uncharacterized protein


chr4_+_175204818 0.419 ENST00000503780.1
 CEP44
centrosomal protein 44kDa

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.9 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 1.6 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 1.0 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.9 GO:0060216 definitive hemopoiesis(GO:0060216)
0.3 0.8 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.8 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.8 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.7 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.7 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.2 0.6 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.6 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.6 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.5 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.1 0.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 0.5 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.1 0.5 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.5 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.5 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.5 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0031941 filamentous actin(GO:0031941)
0.0 1.2 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.8 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.8 GO:0031105 septin complex(GO:0031105)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 0.6 GO:0097447 dendritic tree(GO:0097447)
0.1 0.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.6 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.6 GO:0010369 chromocenter(GO:0010369)
0.1 0.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.5 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.5 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.4 GO:0032437 cuticular plate(GO:0032437)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.1 0.3 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.3 1.1 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 0.9 GO:0017091 AU-rich element binding(GO:0017091)
0.2 0.8 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 0.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.6 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.6 GO:0008483 transaminase activity(GO:0008483)
0.1 0.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.5 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.5 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.5 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.5 GO:0070402 NADPH binding(GO:0070402)
0.0 0.4 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.2 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.6 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.6 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.3 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.3 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing