Motif ID: SP1
Z-value: 1.744
Transcription factors associated with SP1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SP1 | ENSG00000185591.5 | SP1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg19_v2_chr12_+_53774423_53774658 | 0.48 | 1.8e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,352 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.2 | 6.7 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 6.4 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.7 | 5.5 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.4 | 5.3 | GO:0022417 | protein maturation by protein folding(GO:0022417) |
| 0.8 | 4.7 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 0.1 | 4.7 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.8 | 4.6 | GO:0030421 | defecation(GO:0030421) |
| 0.1 | 4.3 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.5 | 4.2 | GO:0036486 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) |
| 0.4 | 4.0 | GO:1905247 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247) |
| 0.2 | 3.9 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 3.8 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.2 | 3.7 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
| 0.2 | 3.7 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.1 | 3.7 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.4 | 3.6 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
| 0.3 | 3.6 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.7 | 3.5 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.2 | 3.5 | GO:0070977 | bone maturation(GO:0070977) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 429 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 37.9 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 16.4 | GO:0005924 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
| 0.1 | 12.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 10.7 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 10.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 10.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 10.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 10.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 8.1 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 7.5 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 7.5 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 7.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 6.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 5.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 5.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 5.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 5.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 5.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 5.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 5.2 | GO:0031902 | late endosome membrane(GO:0031902) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 818 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 17.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 12.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 8.0 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 7.7 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 7.7 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 6.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 6.4 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 1.3 | 6.3 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.3 | 5.8 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 5.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 5.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 5.5 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.3 | 5.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 5.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.5 | 5.0 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.1 | 4.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 4.6 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.1 | 4.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 4.5 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 125 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.2 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 11.0 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 10.5 | PID_INTEGRIN1_PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 9.9 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 9.7 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 8.4 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 8.1 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 7.7 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.3 | 6.6 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.2 | 6.0 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 5.9 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 5.8 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.2 | 5.2 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 5.2 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.1 | 4.9 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 4.7 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.2 | 4.6 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 4.4 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 4.3 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 4.1 | PID_FOXO_PATHWAY | FoxO family signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 201 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.2 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 7.1 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 6.0 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 6.0 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 5.9 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 5.8 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 5.7 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.2 | 5.5 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 5.5 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 5.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 5.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 5.2 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 5.0 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 4.8 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 4.6 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 4.5 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 4.5 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 4.4 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 4.2 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 4.2 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
