Motif ID: SP3

Z-value: 1.590


Transcription factors associated with SP3:

Gene SymbolEntrez IDGene Name
SP3 ENSG00000172845.9 SP3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SP3hg19_v2_chr2_-_174830430_1748305630.242.5e-01Click!


Activity profile for motif SP3.

activity profile for motif SP3


Sorted Z-values histogram for motif SP3

Sorted Z-values for motif SP3



Network of associatons between targets according to the STRING database.



First level regulatory network of SP3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_135192695 4.180 ENST00000368539.4
ENST00000278060.5
ENST00000357296.3
 PAOX


polyamine oxidase (exo-N4-amino)


chrY_+_22737678 4.156 ENST00000382772.3
 EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr10_+_135192782 3.770 ENST00000480071.2
 PAOX
polyamine oxidase (exo-N4-amino)
chr10_+_11784360 3.695 ENST00000379215.4
ENST00000420401.1
 ECHDC3

enoyl CoA hydratase domain containing 3

chrY_+_22737604 3.187 ENST00000361365.2
 EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr1_+_211432775 2.986 ENST00000419091.2
 RCOR3
REST corepressor 3
chrX_+_30671476 2.983 ENST00000378946.3
ENST00000378943.3
ENST00000378945.3
ENST00000427190.1
ENST00000378941.3
 GK




glycerol kinase




chr17_-_76183111 2.946 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
 TK1



thymidine kinase 1, soluble



chr16_-_87903079 2.767 ENST00000261622.4
 SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr14_+_105941118 2.539 ENST00000550577.1
ENST00000538259.2
 CRIP2

cysteine-rich protein 2

chr2_+_95691417 2.481 ENST00000309988.4
 MAL
mal, T-cell differentiation protein
chr3_-_50340996 2.436 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
 HYAL1





hyaluronoglucosaminidase 1





chr6_-_4135693 2.380 ENST00000495548.1
ENST00000380125.2
ENST00000465828.1
 ECI2


enoyl-CoA delta isomerase 2


chr12_-_95044309 2.340 ENST00000261226.4
 TMCC3
transmembrane and coiled-coil domain family 3
chr11_-_2160611 2.340 ENST00000416167.2
 IGF2
insulin-like growth factor 2 (somatomedin A)
chr19_-_14201507 2.302 ENST00000533683.2
 SAMD1
sterile alpha motif domain containing 1
chrY_+_15016725 2.266 ENST00000336079.3
 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr12_-_51785182 2.261 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
 GALNT6



UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)



chrX_+_38420623 2.249 ENST00000378482.2
 TSPAN7
tetraspanin 7
chr6_-_4135825 2.249 ENST00000380118.3
ENST00000413766.2
ENST00000361538.2
 ECI2


enoyl-CoA delta isomerase 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,557 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 GO:0016266 O-glycan processing(GO:0016266)
0.2 9.5 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.9 8.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 8.2 GO:0000725 recombinational repair(GO:0000725)
2.0 8.0 GO:0009447 putrescine catabolic process(GO:0009447)
0.2 8.0 GO:0051310 metaphase plate congression(GO:0051310)
0.4 7.6 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.1 7.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 6.9 GO:0016567 protein ubiquitination(GO:0016567)
1.1 6.3 GO:0006021 inositol biosynthetic process(GO:0006021)
0.2 6.1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2 6.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
1.0 5.8 GO:0030421 defecation(GO:0030421)
0.1 5.5 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
1.8 5.4 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.4 5.4 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.4 5.3 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.2 5.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.2 5.2 GO:0006004 fucose metabolic process(GO:0006004)
0.2 5.1 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 500 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 82.7 GO:0005829 cytosol(GO:0005829)
0.0 66.1 GO:0005739 mitochondrion(GO:0005739)
0.0 19.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.3 19.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 16.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 15.5 GO:0005924 cell-substrate adherens junction(GO:0005924)
0.1 12.6 GO:0005795 Golgi stack(GO:0005795)
0.1 12.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 11.4 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.2 9.1 GO:0005876 spindle microtubule(GO:0005876)
0.0 9.0 GO:0000139 Golgi membrane(GO:0000139)
0.1 8.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 8.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 7.9 GO:0001650 fibrillar center(GO:0001650)
0.0 7.5 GO:0016324 apical plasma membrane(GO:0016324)
0.7 7.2 GO:0000796 condensin complex(GO:0000796)
0.0 7.0 GO:0098857 membrane microdomain(GO:0098857)
0.1 6.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 6.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 6.5 GO:0016604 nuclear body(GO:0016604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 859 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 33.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 9.7 GO:0005096 GTPase activator activity(GO:0005096)
0.2 9.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 8.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.5 7.6 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.3 7.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 7.5 GO:0019208 phosphatase regulator activity(GO:0019208)
0.1 7.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 7.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.4 7.0 GO:0052832 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1 6.7 GO:0043130 ubiquitin binding(GO:0043130)
0.2 6.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 6.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 5.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
1.8 5.4 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.3 5.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 5.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 5.2 GO:0038191 neuropilin binding(GO:0038191)
0.6 5.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.3 5.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 13.1 PID_PLK1_PATHWAY PLK1 signaling events
0.3 12.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 10.4 PID_P73PATHWAY p73 transcription factor network
0.2 10.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 8.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 7.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 7.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 7.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 7.1 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 6.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 4.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 4.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 4.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 3.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 3.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 223 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 15.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 11.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 10.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.4 9.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 9.4 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.2 8.6 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.3 8.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 7.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 7.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 7.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 7.4 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.3 7.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 7.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 6.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 6.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.3 5.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 5.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 5.4 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.3 5.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation