Motif ID: SP4_PML
Z-value: 1.434


Transcription factors associated with SP4_PML:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
PML | ENSG00000140464.15 | PML |
SP4 | ENSG00000105866.9 | SP4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
PML | hg19_v2_chr15_+_74287035_74287117 | 0.51 | 1.1e-02 | Click! |
SP4 | hg19_v2_chr7_+_21467642_21467671 | -0.14 | 5.0e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,385 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.5 | 12.4 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
1.0 | 11.6 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
0.2 | 9.9 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
0.1 | 8.3 | GO:0099601 | regulation of neurotransmitter receptor activity(GO:0099601) |
0.0 | 8.1 | GO:0043687 | post-translational protein modification(GO:0043687) |
0.2 | 7.9 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
1.7 | 6.8 | GO:0072139 | glomerular parietal epithelial cell differentiation(GO:0072139) |
1.0 | 6.1 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
0.3 | 5.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
0.1 | 5.4 | GO:0090662 | ATP hydrolysis coupled transmembrane transport(GO:0090662) |
0.3 | 5.1 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
0.1 | 5.1 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
0.2 | 5.0 | GO:1904380 | endoplasmic reticulum mannose trimming(GO:1904380) |
0.4 | 4.7 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
0.1 | 4.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.4 | 4.4 | GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639) |
0.3 | 4.4 | GO:0060453 | regulation of gastric acid secretion(GO:0060453) |
1.4 | 4.3 | GO:0072034 | renal vesicle induction(GO:0072034) |
0.2 | 4.2 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
0.1 | 4.2 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 391 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 61.2 | GO:0016021 | integral component of membrane(GO:0016021) |
0.0 | 30.7 | GO:0000139 | Golgi membrane(GO:0000139) |
0.1 | 16.1 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
0.1 | 14.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
0.6 | 13.4 | GO:0032591 | dendritic spine membrane(GO:0032591) |
0.1 | 13.2 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
0.1 | 12.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 11.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
0.8 | 9.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
0.1 | 9.7 | GO:0005802 | trans-Golgi network(GO:0005802) |
0.1 | 9.0 | GO:0005796 | Golgi lumen(GO:0005796) |
0.1 | 8.6 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
0.1 | 7.1 | GO:0043204 | perikaryon(GO:0043204) |
0.4 | 6.6 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
0.1 | 6.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.3 | 6.1 | GO:0071141 | SMAD protein complex(GO:0071141) |
0.0 | 5.5 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 5.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.1 | 5.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
0.0 | 5.0 | GO:0010008 | endosome membrane(GO:0010008) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 768 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.4 | 11.9 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
0.0 | 9.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.4 | 9.1 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.3 | 8.9 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
0.1 | 7.6 | GO:0008013 | beta-catenin binding(GO:0008013) |
0.0 | 7.3 | GO:0005125 | cytokine activity(GO:0005125) |
0.1 | 6.8 | GO:0042805 | actinin binding(GO:0042805) |
0.0 | 6.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.1 | 6.6 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
0.6 | 6.3 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
0.0 | 6.3 | GO:0002020 | protease binding(GO:0002020) |
0.5 | 6.1 | GO:0019826 | oxygen sensor activity(GO:0019826) |
0.4 | 5.9 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
0.3 | 5.7 | GO:0019992 | diacylglycerol binding(GO:0019992) |
0.2 | 5.7 | GO:0048018 | receptor agonist activity(GO:0048018) |
0.2 | 5.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.0 | 5.3 | GO:0005178 | integrin binding(GO:0005178) |
0.2 | 5.2 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.1 | 5.2 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
0.3 | 5.1 | GO:1990459 | transferrin receptor binding(GO:1990459) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 105 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 17.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.2 | 16.1 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.1 | 15.1 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 11.0 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.1 | 10.6 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.1 | 10.6 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.4 | 9.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.1 | 8.8 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
0.1 | 7.8 | PID_CD40_PATHWAY | CD40/CD40L signaling |
0.1 | 6.6 | PID_BMP_PATHWAY | BMP receptor signaling |
0.1 | 6.2 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.3 | 5.9 | PID_ALK2_PATHWAY | ALK2 signaling events |
0.1 | 5.5 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
0.0 | 5.3 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
0.0 | 4.9 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.1 | 4.2 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.1 | 4.2 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
0.1 | 3.9 | PID_IGF1_PATHWAY | IGF1 pathway |
0.0 | 3.9 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
0.1 | 3.6 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 183 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 10.7 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
0.2 | 8.9 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.2 | 8.1 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.2 | 7.9 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.4 | 7.7 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
0.1 | 7.5 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.2 | 7.3 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
0.1 | 6.4 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
0.1 | 6.1 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
0.1 | 5.3 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
0.1 | 5.1 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.2 | 5.0 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
0.1 | 5.0 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
0.0 | 5.0 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
0.1 | 4.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.2 | 4.6 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.1 | 4.6 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
0.2 | 4.5 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.2 | 4.2 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.1 | 4.0 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |