Motif ID: SP4_PML

Z-value: 1.434

Transcription factors associated with SP4_PML:

Gene SymbolEntrez IDGene Name
PML ENSG00000140464.15 PML
SP4 ENSG00000105866.9 SP4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PMLhg19_v2_chr15_+_74287035_742871170.511.1e-02Click!
SP4hg19_v2_chr7_+_21467642_21467671-0.145.0e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of SP4_PML

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_708910 6.174 ENST00000264560.7
PALM
paralemmin
chr19_+_709101 5.988 ENST00000338448.5
PALM
paralemmin
chr22_+_39853258 5.007 ENST00000341184.6
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr1_+_205538105 4.758 ENST00000367147.4
ENST00000539267.1
MFSD4

major facilitator superfamily domain containing 4

chr7_-_158380371 4.529 ENST00000389418.4
ENST00000389416.4
PTPRN2

protein tyrosine phosphatase, receptor type, N polypeptide 2

chr5_-_180018540 4.422 ENST00000292641.3
SCGB3A1
secretoglobin, family 3A, member 1
chr7_-_158380465 4.088 ENST00000389413.3
ENST00000409483.1
PTPRN2

protein tyrosine phosphatase, receptor type, N polypeptide 2

chr1_-_22469459 3.911 ENST00000290167.6
WNT4
wingless-type MMTV integration site family, member 4
chr7_-_51384451 3.764 ENST00000441453.1
ENST00000265136.7
ENST00000395542.2
ENST00000395540.2
COBL



cordon-bleu WH2 repeat protein



chr16_+_67465016 3.579 ENST00000326152.5
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr3_+_13590619 3.555 ENST00000404922.3
FBLN2
fibulin 2
chr3_-_45267760 3.516 ENST00000503771.1
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr3_+_13590636 3.436 ENST00000295760.7
FBLN2
fibulin 2
chr6_-_29595779 3.295 ENST00000355973.3
ENST00000377012.4
GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr4_-_16085340 3.289 ENST00000508167.1
PROM1
prominin 1
chr2_+_10861775 3.240 ENST00000272238.4
ENST00000381661.3
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr4_-_16085314 3.213 ENST00000510224.1
PROM1
prominin 1
chr9_-_21994597 3.196 ENST00000579755.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr19_-_3029011 3.132 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
TLE2



transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)



chr10_-_13043697 3.069 ENST00000378825.3
CCDC3
coiled-coil domain containing 3

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,385 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 12.4 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
1.0 11.6 GO:2000111 positive regulation of macrophage apoptotic process(GO:2000111)
0.2 9.9 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 8.3 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 8.1 GO:0043687 post-translational protein modification(GO:0043687)
0.2 7.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
1.7 6.8 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
1.0 6.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.3 5.4 GO:0071420 cellular response to histamine(GO:0071420)
0.1 5.4 GO:0090662 ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.3 5.1 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.1 5.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 5.0 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.4 4.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 4.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.4 4.4 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.3 4.4 GO:0060453 regulation of gastric acid secretion(GO:0060453)
1.4 4.3 GO:0072034 renal vesicle induction(GO:0072034)
0.2 4.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 4.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 391 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 61.2 GO:0016021 integral component of membrane(GO:0016021)
0.0 30.7 GO:0000139 Golgi membrane(GO:0000139)
0.1 16.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 14.2 GO:0043202 lysosomal lumen(GO:0043202)
0.6 13.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 13.2 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 12.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 11.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.8 9.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 9.7 GO:0005802 trans-Golgi network(GO:0005802)
0.1 9.0 GO:0005796 Golgi lumen(GO:0005796)
0.1 8.6 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.1 7.1 GO:0043204 perikaryon(GO:0043204)
0.4 6.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 6.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 6.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 5.5 GO:0016607 nuclear speck(GO:0016607)
0.0 5.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 5.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 5.0 GO:0010008 endosome membrane(GO:0010008)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 768 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 11.9 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.0 9.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 9.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 8.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 7.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 7.3 GO:0005125 cytokine activity(GO:0005125)
0.1 6.8 GO:0042805 actinin binding(GO:0042805)
0.0 6.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 6.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.6 6.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 6.3 GO:0002020 protease binding(GO:0002020)
0.5 6.1 GO:0019826 oxygen sensor activity(GO:0019826)
0.4 5.9 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.3 5.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 5.7 GO:0048018 receptor agonist activity(GO:0048018)
0.2 5.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 5.3 GO:0005178 integrin binding(GO:0005178)
0.2 5.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 5.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 5.1 GO:1990459 transferrin receptor binding(GO:1990459)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 16.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 15.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 11.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 10.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 10.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 9.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 8.8 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 7.8 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 6.6 PID_BMP_PATHWAY BMP receptor signaling
0.1 6.2 PID_LKB1_PATHWAY LKB1 signaling events
0.3 5.9 PID_ALK2_PATHWAY ALK2 signaling events
0.1 5.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 5.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 4.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.2 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.2 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.9 PID_IGF1_PATHWAY IGF1 pathway
0.0 3.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 3.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2 8.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 8.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 7.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 7.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 7.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 7.3 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 6.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 6.1 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 5.3 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 5.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 5.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 5.0 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 5.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 4.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.6 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 4.6 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.2 4.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.2 4.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 4.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix