Motif ID: SPDEF

Z-value: 0.869


Transcription factors associated with SPDEF:

Gene SymbolEntrez IDGene Name
SPDEF ENSG00000124664.6 SPDEF

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPDEFhg19_v2_chr6_-_34524093_345241350.583.1e-03Click!


Activity profile for motif SPDEF.

activity profile for motif SPDEF


Sorted Z-values histogram for motif SPDEF

Sorted Z-values for motif SPDEF



Network of associatons between targets according to the STRING database.



First level regulatory network of SPDEF

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_84630645 1.774 ENST00000394839.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_84630053 1.774 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
 PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr16_+_77225071 1.583 ENST00000439557.2
ENST00000545553.1
 MON1B

MON1 secretory trafficking family member B

chr4_+_153701081 1.450 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
 ARFIP1




ADP-ribosylation factor interacting protein 1




chr12_-_123201337 1.415 ENST00000528880.2
 HCAR3
hydroxycarboxylic acid receptor 3
chr12_-_123187890 1.394 ENST00000328880.5
 HCAR2
hydroxycarboxylic acid receptor 2
chr5_+_110074685 1.336 ENST00000355943.3
ENST00000447245.2
 SLC25A46

solute carrier family 25, member 46

chr6_-_43484621 1.218 ENST00000506469.1
ENST00000503972.1
 YIPF3

Yip1 domain family, member 3

chr11_-_58345569 1.200 ENST00000528954.1
ENST00000528489.1
 LPXN

leupaxin

chrX_+_69509927 1.137 ENST00000374403.3
 KIF4A
kinesin family member 4A
chr5_-_114961673 1.129 ENST00000333314.3
 TMED7-TICAM2
TMED7-TICAM2 readthrough
chr6_-_43484718 1.120 ENST00000372422.2
 YIPF3
Yip1 domain family, member 3
chr1_+_169337172 1.054 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
 BLZF1



basic leucine zipper nuclear factor 1



chr2_+_48667983 1.039 ENST00000449090.2
 PPP1R21
protein phosphatase 1, regulatory subunit 21
chrX_+_47444613 1.031 ENST00000445623.1
 TIMP1
TIMP metallopeptidase inhibitor 1
chr20_-_48532046 1.010 ENST00000543716.1
 SPATA2
spermatogenesis associated 2
chr8_+_15397732 0.995 ENST00000382020.4
ENST00000506802.1
ENST00000509380.1
ENST00000503731.1
 TUSC3



tumor suppressor candidate 3



chr7_+_93551011 0.966 ENST00000248564.5
 GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr3_-_37217756 0.938 ENST00000440230.1
ENST00000421276.2
ENST00000421307.1
ENST00000354379.4
 LRRFIP2



leucine rich repeat (in FLII) interacting protein 2



chr4_-_153700864 0.926 ENST00000304337.2
 TIGD4
tigger transposable element derived 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.6 GO:0097338 response to clozapine(GO:0097338)
0.7 2.1 GO:0019085 early viral transcription(GO:0019085)
0.2 1.4 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 1.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 1.4 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.4 1.3 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 1.3 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.1 1.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 1.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 1.2 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 1.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.1 GO:0021670 lateral ventricle development(GO:0021670)
0.0 1.1 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.2 1.0 GO:0070889 platelet alpha granule organization(GO:0070889)
0.2 1.0 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 1.0 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 1.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.0 GO:0015693 magnesium ion transport(GO:0015693)
0.3 0.9 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.9 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.8 GO:0005685 U1 snRNP(GO:0005685)
0.1 1.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.6 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.1 1.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.1 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.1 GO:0042588 zymogen granule(GO:0042588)
0.1 1.1 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 1.1 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 0.8 GO:0097443 sorting endosome(GO:0097443)
0.0 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 0.6 GO:0044609 DBIRD complex(GO:0044609)
0.2 0.6 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.2 0.6 GO:0005846 nuclear cap binding complex(GO:0005846)
0.1 0.6 GO:0042643 actomyosin, actin portion(GO:0042643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 2.5 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 1.8 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 1.5 GO:0030275 LRR domain binding(GO:0030275)
0.0 1.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.1 GO:0070628 proteasome binding(GO:0070628)
0.2 1.0 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 0.9 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.3 0.8 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.8 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.8 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 0.7 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.6 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.6 GO:0089720 caspase binding(GO:0089720)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.2 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.1 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.8 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.8 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.4 ST_GAQ_PATHWAY G alpha q Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.2 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.7 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 1.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.3 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.1 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 0.9 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.9 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.8 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.6 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)