Motif ID: SPIB

Z-value: 0.870


Transcription factors associated with SPIB:

Gene SymbolEntrez IDGene Name
SPIB ENSG00000269404.2 SPIB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPIBhg19_v2_chr19_+_50922187_509222150.501.3e-02Click!


Activity profile for motif SPIB.

activity profile for motif SPIB


Sorted Z-values histogram for motif SPIB

Sorted Z-values for motif SPIB



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51471362 7.324 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr19_-_51471381 7.251 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr1_+_120839412 3.520 ENST00000355228.4
 FAM72B
family with sequence similarity 72, member B
chr1_+_206138884 3.222 ENST00000341209.5
ENST00000607379.1
 FAM72A

family with sequence similarity 72, member A

chr2_+_113885138 2.637 ENST00000409930.3
 IL1RN
interleukin 1 receptor antagonist
chr19_+_48828788 2.572 ENST00000594198.1
ENST00000597279.1
ENST00000593437.1
 EMP3


epithelial membrane protein 3


chr19_+_48828582 2.368 ENST00000270221.6
ENST00000596315.1
 EMP3

epithelial membrane protein 3

chr12_+_15699286 2.176 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
 PTPRO



protein tyrosine phosphatase, receptor type, O



chr22_-_37640456 2.028 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
 RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr19_+_54371114 2.013 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
 MYADM



myeloid-associated differentiation marker



chr10_-_121302195 1.969 ENST00000369103.2
 RGS10
regulator of G-protein signaling 10
chr22_-_37640277 1.902 ENST00000401529.3
ENST00000249071.6
 RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

chr2_+_233925064 1.889 ENST00000359570.5
ENST00000538935.1
 INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr5_-_39270725 1.812 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
 FYB


FYN binding protein


chr2_-_208031943 1.784 ENST00000421199.1
ENST00000457962.1
 KLF7

Kruppel-like factor 7 (ubiquitous)

chr3_+_121774202 1.678 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
 CD86



CD86 molecule



chr3_+_121796697 1.670 ENST00000482356.1
ENST00000393627.2
 CD86

CD86 molecule

chr1_-_43855444 1.652 ENST00000372455.4
 MED8
mediator complex subunit 8
chr2_-_190044480 1.631 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr22_-_37915535 1.626 ENST00000403299.1
 CARD10
caspase recruitment domain family, member 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 14.6 GO:0016540 protein autoprocessing(GO:0016540)
0.2 5.5 GO:0032060 bleb assembly(GO:0032060)
0.4 3.9 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.7 3.7 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.1 3.3 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.3 2.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.7 2.2 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.3 2.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 2.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.5 2.0 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.6 1.9 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.0 1.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.8 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 1.7 GO:0015914 phospholipid transport(GO:0015914)
0.5 1.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 1.6 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 1.6 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.1 1.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 1.6 GO:1901998 toxin transport(GO:1901998)
0.5 1.5 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.1 GO:0030141 secretory granule(GO:0030141)
0.0 4.7 GO:0043197 dendritic spine(GO:0043197)
0.0 3.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 3.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.8 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 1.7 GO:0001891 phagocytic cup(GO:0001891)
0.5 1.6 GO:0005588 collagen type V trimer(GO:0005588)
0.3 1.6 GO:0032449 CBM complex(GO:0032449)
0.2 1.6 GO:0032010 phagolysosome(GO:0032010)
0.0 1.5 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 1.4 GO:0035580 specific granule lumen(GO:0035580)
0.3 1.3 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.1 1.3 GO:0005861 troponin complex(GO:0005861)
0.1 1.2 GO:0008278 cohesin complex(GO:0008278)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.0 1.2 GO:0005884 actin filament(GO:0005884)
0.1 1.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 3.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 3.5 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.4 GO:0015026 coreceptor activity(GO:0015026)
0.0 3.0 GO:0019887 protein kinase regulator activity(GO:0019887)
0.9 2.6 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 2.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 1.9 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 1.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3 1.6 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.1 1.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 1.5 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.2 1.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 1.5 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 1.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.3 GO:0031014 troponin T binding(GO:0031014)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 5.6 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 3.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 3.0 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 2.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 2.1 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 1.1 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.6 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 2.7 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 2.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 2.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 2.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.5 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.2 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.1 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.1 1.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.0 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)