Motif ID: SPIB
Z-value: 0.870
Transcription factors associated with SPIB:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
SPIB | ENSG00000269404.2 | SPIB |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
SPIB | hg19_v2_chr19_+_50922187_50922215 | 0.50 | 1.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.3 | GO:0002644 | negative regulation of tolerance induction(GO:0002644) |
0.7 | 3.7 | GO:0071477 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
0.7 | 2.2 | GO:0036058 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
0.7 | 14.6 | GO:0016540 | protein autoprocessing(GO:0016540) |
0.6 | 1.9 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
0.5 | 1.6 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.5 | 2.0 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
0.5 | 1.5 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076) |
0.4 | 1.2 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
0.4 | 3.9 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
0.3 | 1.6 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
0.3 | 1.3 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
0.3 | 0.9 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
0.3 | 2.6 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
0.3 | 1.4 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
0.3 | 2.1 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
0.3 | 1.5 | GO:0061502 | early endosome to recycling endosome transport(GO:0061502) |
0.2 | 1.5 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
0.2 | 5.5 | GO:0032060 | bleb assembly(GO:0032060) |
0.2 | 0.6 | GO:0072579 | molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579) |
0.2 | 1.2 | GO:0010897 | negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252) |
0.2 | 0.8 | GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
0.2 | 0.8 | GO:0071484 | response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484) |
0.2 | 0.7 | GO:0042223 | positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) |
0.2 | 0.7 | GO:0072092 | ureteric bud invasion(GO:0072092) |
0.2 | 0.7 | GO:0007198 | adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) |
0.2 | 1.0 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
0.1 | 1.6 | GO:0009407 | toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487) |
0.1 | 0.6 | GO:0060322 | head development(GO:0060322) |
0.1 | 0.6 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
0.1 | 0.8 | GO:0036015 | response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016) |
0.1 | 0.8 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
0.1 | 0.4 | GO:0002605 | negative regulation of dendritic cell antigen processing and presentation(GO:0002605) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318) |
0.1 | 0.7 | GO:0070945 | neutrophil mediated killing of gram-negative bacterium(GO:0070945) |
0.1 | 1.3 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
0.1 | 1.4 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
0.1 | 0.5 | GO:0072717 | cellular response to actinomycin D(GO:0072717) |
0.1 | 0.3 | GO:0036512 | trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512) |
0.1 | 0.4 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
0.1 | 0.7 | GO:0060480 | lung goblet cell differentiation(GO:0060480) |
0.1 | 0.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
0.1 | 1.2 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
0.1 | 0.4 | GO:1901895 | regulation of interleukin-18 production(GO:0032661) positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of calcium-transporting ATPase activity(GO:1901895) |
0.1 | 2.1 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
0.1 | 0.3 | GO:1990737 | response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
0.1 | 1.5 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
0.1 | 1.4 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
0.1 | 1.2 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
0.1 | 0.2 | GO:0031630 | regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630) |
0.1 | 0.5 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.1 | 0.7 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
0.1 | 0.9 | GO:0000733 | DNA strand renaturation(GO:0000733) |
0.1 | 0.2 | GO:0043686 | co-translational protein modification(GO:0043686) |
0.1 | 0.3 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
0.1 | 0.5 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
0.1 | 1.6 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
0.1 | 0.4 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
0.1 | 0.8 | GO:2000111 | senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111) |
0.1 | 0.4 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
0.1 | 0.2 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
0.1 | 0.4 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
0.1 | 0.3 | GO:0001992 | regulation of systemic arterial blood pressure by vasopressin(GO:0001992) |
0.1 | 0.2 | GO:1902463 | protein localization to cell leading edge(GO:1902463) |
0.1 | 0.7 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
0.1 | 0.8 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
0.1 | 1.4 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
0.1 | 0.3 | GO:1902378 | vestibulocochlear nerve structural organization(GO:0021649) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) positive regulation of retinal ganglion cell axon guidance(GO:1902336) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
0.1 | 0.7 | GO:0043249 | erythrocyte maturation(GO:0043249) |
0.1 | 0.6 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
0.1 | 0.3 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
0.1 | 0.4 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
0.1 | 0.5 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
0.0 | 0.1 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
0.0 | 0.1 | GO:1990637 | response to prolactin(GO:1990637) |
0.0 | 0.1 | GO:0032672 | interleukin-3 production(GO:0032632) regulation of interleukin-3 production(GO:0032672) |
0.0 | 0.5 | GO:0015886 | heme transport(GO:0015886) |
0.0 | 0.2 | GO:0036229 | glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803) |
0.0 | 0.3 | GO:2000568 | memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568) |
0.0 | 0.3 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
0.0 | 1.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.0 | 0.2 | GO:0007525 | somatic muscle development(GO:0007525) |
0.0 | 0.2 | GO:0071673 | positive regulation of smooth muscle cell chemotaxis(GO:0071673) |
0.0 | 0.1 | GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
0.0 | 0.1 | GO:1904058 | positive regulation of sensory perception of pain(GO:1904058) |
0.0 | 0.6 | GO:0002115 | store-operated calcium entry(GO:0002115) |
0.0 | 0.2 | GO:0070383 | DNA cytosine deamination(GO:0070383) |
0.0 | 0.1 | GO:2000612 | thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612) |
0.0 | 0.3 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
0.0 | 0.3 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.0 | 0.7 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
0.0 | 0.1 | GO:1902227 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
0.0 | 0.4 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.0 | 0.4 | GO:0032071 | regulation of endodeoxyribonuclease activity(GO:0032071) |
0.0 | 0.3 | GO:0090481 | pyrimidine nucleotide-sugar transmembrane transport(GO:0090481) |
0.0 | 0.3 | GO:0060613 | fat pad development(GO:0060613) |
0.0 | 0.2 | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) |
0.0 | 0.6 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
0.0 | 0.3 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
0.0 | 0.5 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.0 | 1.0 | GO:0097503 | sialylation(GO:0097503) |
0.0 | 1.6 | GO:1901998 | toxin transport(GO:1901998) |
0.0 | 0.4 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.0 | 0.3 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
0.0 | 0.4 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
0.0 | 0.4 | GO:0035878 | nail development(GO:0035878) |
0.0 | 0.2 | GO:2000812 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) regulation of barbed-end actin filament capping(GO:2000812) |
0.0 | 0.6 | GO:0006465 | signal peptide processing(GO:0006465) |
0.0 | 0.4 | GO:0090168 | Golgi reassembly(GO:0090168) |
0.0 | 0.1 | GO:0039019 | pronephric nephron development(GO:0039019) |
0.0 | 0.4 | GO:0005513 | detection of calcium ion(GO:0005513) |
0.0 | 0.1 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
0.0 | 0.0 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
0.0 | 0.1 | GO:2000609 | regulation of thyroid hormone generation(GO:2000609) |
0.0 | 1.7 | GO:0015914 | phospholipid transport(GO:0015914) |
0.0 | 1.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
0.0 | 0.1 | GO:0061198 | fungiform papilla formation(GO:0061198) |
0.0 | 1.1 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
0.0 | 0.3 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
0.0 | 0.7 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
0.0 | 0.1 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
0.0 | 0.1 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
0.0 | 0.3 | GO:0008284 | positive regulation of cell proliferation(GO:0008284) |
0.0 | 0.2 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
0.0 | 0.6 | GO:0006376 | mRNA splice site selection(GO:0006376) |
0.0 | 0.4 | GO:0051764 | actin crosslink formation(GO:0051764) |
0.0 | 0.5 | GO:0007398 | ectoderm development(GO:0007398) |
0.0 | 0.9 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
0.0 | 0.9 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
0.0 | 0.7 | GO:0006308 | DNA catabolic process(GO:0006308) |
0.0 | 1.0 | GO:0016266 | O-glycan processing(GO:0016266) |
0.0 | 0.7 | GO:0097178 | ruffle assembly(GO:0097178) |
0.0 | 0.1 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.0 | 0.2 | GO:0060022 | hard palate development(GO:0060022) |
0.0 | 0.3 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
0.0 | 1.1 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
0.0 | 0.0 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
0.0 | 0.1 | GO:0014718 | positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) |
0.0 | 0.1 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
0.0 | 0.0 | GO:0032482 | Rab protein signal transduction(GO:0032482) regulation of Rab protein signal transduction(GO:0032483) |
0.0 | 0.5 | GO:0030855 | epithelial cell differentiation(GO:0030855) |
0.0 | 0.3 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
0.0 | 0.5 | GO:0008089 | anterograde axonal transport(GO:0008089) |
0.0 | 0.4 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
0.0 | 0.0 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
0.0 | 1.4 | GO:0007127 | meiosis I(GO:0007127) |
0.0 | 0.1 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
0.0 | 1.8 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
0.0 | 0.8 | GO:0006968 | cellular defense response(GO:0006968) |
0.0 | 0.4 | GO:0008038 | neuron recognition(GO:0008038) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.6 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.3 | 1.6 | GO:0032449 | CBM complex(GO:0032449) |
0.3 | 1.3 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
0.2 | 0.9 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
0.2 | 1.6 | GO:0032010 | phagolysosome(GO:0032010) |
0.2 | 1.0 | GO:0005602 | complement component C1 complex(GO:0005602) |
0.2 | 0.8 | GO:0045160 | myosin I complex(GO:0045160) |
0.1 | 0.6 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
0.1 | 1.4 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.1 | 0.6 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
0.1 | 0.9 | GO:0019815 | B cell receptor complex(GO:0019815) |
0.1 | 1.2 | GO:0008278 | cohesin complex(GO:0008278) |
0.1 | 0.6 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
0.1 | 0.4 | GO:0097362 | MCM8-MCM9 complex(GO:0097362) |
0.1 | 0.3 | GO:0034657 | GID complex(GO:0034657) |
0.1 | 0.7 | GO:0070847 | core mediator complex(GO:0070847) |
0.1 | 1.8 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
0.1 | 1.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
0.1 | 1.7 | GO:0001891 | phagocytic cup(GO:0001891) |
0.1 | 0.6 | GO:0005787 | signal peptidase complex(GO:0005787) |
0.1 | 0.8 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
0.1 | 0.6 | GO:0097443 | sorting endosome(GO:0097443) |
0.1 | 1.3 | GO:0005861 | troponin complex(GO:0005861) |
0.1 | 0.4 | GO:0032009 | early phagosome(GO:0032009) |
0.0 | 0.2 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
0.0 | 3.9 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
0.0 | 0.8 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.0 | 0.1 | GO:0071159 | NF-kappaB complex(GO:0071159) |
0.0 | 1.2 | GO:0016592 | mediator complex(GO:0016592) |
0.0 | 0.2 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
0.0 | 0.4 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
0.0 | 1.0 | GO:0005921 | gap junction(GO:0005921) |
0.0 | 0.4 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 0.3 | GO:0016461 | unconventional myosin complex(GO:0016461) |
0.0 | 0.1 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
0.0 | 0.2 | GO:0035976 | AP1 complex(GO:0035976) |
0.0 | 0.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.0 | 0.3 | GO:0001673 | male germ cell nucleus(GO:0001673) |
0.0 | 0.1 | GO:0005955 | calcineurin complex(GO:0005955) |
0.0 | 2.2 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
0.0 | 4.7 | GO:0043197 | dendritic spine(GO:0043197) |
0.0 | 0.5 | GO:0045335 | phagocytic vesicle(GO:0045335) |
0.0 | 0.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
0.0 | 0.1 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 0.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
0.0 | 0.2 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
0.0 | 3.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.0 | 1.4 | GO:0035580 | specific granule lumen(GO:0035580) |
0.0 | 0.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
0.0 | 0.3 | GO:0046930 | pore complex(GO:0046930) |
0.0 | 0.4 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
0.0 | 0.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.0 | 0.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.0 | 1.5 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 1.2 | GO:0005884 | actin filament(GO:0005884) |
0.0 | 0.3 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.0 | 0.3 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.0 | 11.1 | GO:0030141 | secretory granule(GO:0030141) |
0.0 | 1.1 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 3.4 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.6 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
0.5 | 1.5 | GO:0036134 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
0.3 | 3.7 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
0.3 | 1.9 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
0.3 | 1.6 | GO:0050610 | oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
0.3 | 1.0 | GO:0052798 | beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798) |
0.2 | 0.7 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
0.2 | 0.6 | GO:0061599 | molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599) |
0.2 | 1.3 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.2 | 1.2 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
0.2 | 1.5 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.2 | 0.8 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
0.2 | 0.5 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
0.2 | 1.2 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
0.1 | 0.5 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
0.1 | 0.9 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
0.1 | 1.0 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
0.1 | 0.6 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
0.1 | 1.6 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
0.1 | 0.5 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
0.1 | 0.4 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.1 | 1.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
0.1 | 1.3 | GO:0031014 | troponin T binding(GO:0031014) |
0.1 | 1.5 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
0.1 | 0.2 | GO:0052810 | 1-phosphatidylinositol-5-kinase activity(GO:0052810) |
0.1 | 0.9 | GO:0036310 | annealing helicase activity(GO:0036310) |
0.1 | 2.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.1 | 0.6 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
0.1 | 0.2 | GO:0004914 | interleukin-5 receptor activity(GO:0004914) |
0.1 | 0.3 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
0.1 | 0.3 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.1 | 0.7 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
0.1 | 1.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.1 | 1.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
0.1 | 1.4 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.1 | 0.5 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.1 | 3.4 | GO:0015026 | coreceptor activity(GO:0015026) |
0.1 | 1.2 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
0.1 | 0.3 | GO:0039552 | RIG-I binding(GO:0039552) |
0.1 | 0.5 | GO:0019957 | C-C chemokine binding(GO:0019957) |
0.1 | 16.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 0.5 | GO:0015232 | heme transporter activity(GO:0015232) |
0.0 | 1.5 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
0.0 | 0.4 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
0.0 | 0.3 | GO:0023030 | MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030) |
0.0 | 0.5 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
0.0 | 0.7 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
0.0 | 0.7 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
0.0 | 1.0 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.3 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.0 | 0.5 | GO:0019966 | interleukin-1 binding(GO:0019966) |
0.0 | 0.8 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.0 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.6 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.0 | 0.8 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
0.0 | 0.4 | GO:0042608 | T cell receptor binding(GO:0042608) |
0.0 | 0.4 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
0.0 | 0.3 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
0.0 | 0.5 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
0.0 | 0.2 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
0.0 | 0.3 | GO:0005000 | vasopressin receptor activity(GO:0005000) |
0.0 | 0.3 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
0.0 | 0.1 | GO:0051538 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538) |
0.0 | 0.2 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
0.0 | 0.2 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
0.0 | 0.7 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
0.0 | 0.2 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
0.0 | 0.4 | GO:0035197 | siRNA binding(GO:0035197) |
0.0 | 0.2 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
0.0 | 0.4 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
0.0 | 0.1 | GO:0001032 | RNA polymerase III type 3 promoter DNA binding(GO:0001032) |
0.0 | 0.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
0.0 | 0.1 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.0 | 0.7 | GO:0008198 | ferrous iron binding(GO:0008198) |
0.0 | 0.2 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
0.0 | 0.1 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
0.0 | 0.4 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
0.0 | 1.0 | GO:0036002 | pre-mRNA binding(GO:0036002) |
0.0 | 0.3 | GO:0005549 | odorant binding(GO:0005549) |
0.0 | 0.1 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.0 | 0.2 | GO:0051434 | BH3 domain binding(GO:0051434) |
0.0 | 3.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
0.0 | 0.6 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
0.0 | 0.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
0.0 | 0.1 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
0.0 | 0.4 | GO:0019841 | retinol binding(GO:0019841) |
0.0 | 0.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.0 | 0.4 | GO:0019789 | SUMO transferase activity(GO:0019789) |
0.0 | 0.1 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
0.0 | 1.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.1 | GO:0032357 | oxidized purine DNA binding(GO:0032357) |
0.0 | 0.4 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
0.0 | 0.3 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.0 | 0.3 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
0.0 | 0.3 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
0.0 | 3.0 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
0.0 | 0.2 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.2 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
0.0 | 0.6 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
0.0 | 0.1 | GO:0004985 | opioid receptor activity(GO:0004985) |
0.0 | 0.2 | GO:0048038 | quinone binding(GO:0048038) |
0.0 | 0.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.0 | 0.2 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.2 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.0 | 0.1 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
0.0 | 0.1 | GO:0004875 | complement receptor activity(GO:0004875) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 15.9 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.1 | 5.6 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
0.1 | 1.1 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
0.1 | 3.0 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
0.1 | 3.3 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
0.1 | 1.4 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.0 | 0.9 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
0.0 | 2.2 | PID_IL1_PATHWAY | IL1-mediated signaling events |
0.0 | 2.1 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
0.0 | 1.2 | PID_IL3_PATHWAY | IL3-mediated signaling events |
0.0 | 0.4 | PID_EPO_PATHWAY | EPO signaling pathway |
0.0 | 1.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 0.8 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 1.6 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 1.6 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
0.0 | 0.8 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
0.0 | 0.1 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
0.0 | 1.7 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.0 | 0.3 | PID_RHOA_PATHWAY | RhoA signaling pathway |
0.0 | 1.0 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
0.0 | 0.3 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
0.0 | 0.3 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.0 | 0.4 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
0.0 | 0.3 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.0 | 1.1 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
0.0 | 0.6 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
0.0 | 0.6 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.0 | 0.3 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.0 | 2.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 7.3 | REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE | Genes involved in GPVI-mediated activation cascade |
0.1 | 2.7 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
0.1 | 2.3 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
0.1 | 1.1 | REACTOME_REGULATION_OF_SIGNALING_BY_CBL | Genes involved in Regulation of signaling by CBL |
0.1 | 0.6 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
0.1 | 1.1 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
0.1 | 1.0 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.1 | 0.4 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
0.1 | 1.4 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.1 | 1.2 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
0.0 | 1.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 0.6 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
0.0 | 0.7 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
0.0 | 1.4 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
0.0 | 2.2 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
0.0 | 0.3 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
0.0 | 2.6 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
0.0 | 0.9 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
0.0 | 1.6 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.0 | 1.0 | REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
0.0 | 0.4 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
0.0 | 0.6 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.0 | 0.6 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.0 | 0.4 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
0.0 | 0.5 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
0.0 | 0.4 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
0.0 | 1.5 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
0.0 | 0.5 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
0.0 | 1.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 1.5 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.0 | 0.4 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.0 | 0.8 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
0.0 | 0.2 | REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
0.0 | 2.0 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.0 | 0.5 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
0.0 | 0.5 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.0 | 0.8 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 1.3 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
0.0 | 2.4 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.0 | 0.5 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
0.0 | 1.0 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
0.0 | 0.6 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
0.0 | 0.8 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
0.0 | 0.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.0 | 0.4 | REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |