Motif ID: SPIC

Z-value: 0.994


Transcription factors associated with SPIC:

Gene SymbolEntrez IDGene Name
SPIC ENSG00000166211.6 SPIC

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPIChg19_v2_chr12_+_101869096_1018691990.135.4e-01Click!


Activity profile for motif SPIC.

activity profile for motif SPIC


Sorted Z-values histogram for motif SPIC

Sorted Z-values for motif SPIC



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIC

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_8201091 4.750 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
 SH3TC1



SH3 domain and tetratricopeptide repeats 1



chr19_-_51471362 3.440 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr19_-_51471381 3.368 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr12_+_15699286 2.985 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
 PTPRO



protein tyrosine phosphatase, receptor type, O



chr2_-_113594279 2.593 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr12_+_8975061 2.462 ENST00000299698.7
 A2ML1
alpha-2-macroglobulin-like 1
chr4_-_80994471 2.382 ENST00000295465.4
 ANTXR2
anthrax toxin receptor 2
chr3_-_111314230 2.311 ENST00000317012.4
 ZBED2
zinc finger, BED-type containing 2
chr18_-_33077556 2.218 ENST00000589273.1
ENST00000586489.1
 INO80C

INO80 complex subunit C

chr2_+_113885138 2.062 ENST00000409930.3
 IL1RN
interleukin 1 receptor antagonist
chr5_+_33936491 2.056 ENST00000330120.3
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr4_-_57547454 2.053 ENST00000556376.2
 HOPX
HOP homeobox
chr2_+_233925064 2.050 ENST00000359570.5
ENST00000538935.1
 INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr19_+_35645618 2.039 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
 FXYD5






FXYD domain containing ion transport regulator 5






chr19_-_15344243 1.994 ENST00000602233.1
 EPHX3
epoxide hydrolase 3
chr19_-_51456344 1.942 ENST00000336334.3
ENST00000593428.1
 KLK5

kallikrein-related peptidase 5

chr19_-_51456321 1.919 ENST00000391809.2
 KLK5
kallikrein-related peptidase 5
chr15_-_80263506 1.910 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr4_-_80994619 1.856 ENST00000404191.1
 ANTXR2
anthrax toxin receptor 2
chr1_-_43855444 1.772 ENST00000372455.4
 MED8
mediator complex subunit 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 325 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.8 GO:0016540 protein autoprocessing(GO:0016540)
0.9 5.6 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
1.2 3.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.0 3.4 GO:0006338 chromatin remodeling(GO:0006338)
0.1 3.2 GO:1901998 toxin transport(GO:1901998)
1.0 3.0 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.9 2.6 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.4 2.5 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 2.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 2.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.4 2.2 GO:0044565 dendritic cell proliferation(GO:0044565)
0.2 2.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 2.2 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 2.2 GO:0051639 actin filament network formation(GO:0051639)
0.1 2.2 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.7 2.0 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 2.0 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 2.0 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 2.0 GO:0060976 coronary vasculature development(GO:0060976)
0.0 2.0 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 4.1 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 3.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 2.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.8 GO:0030018 Z disc(GO:0030018)
0.0 2.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.4 GO:0072562 blood microparticle(GO:0072562)
0.1 2.2 GO:0005916 fascia adherens(GO:0005916)
0.0 2.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.8 GO:0016592 mediator complex(GO:0016592)
0.1 1.7 GO:0097228 sperm principal piece(GO:0097228)
0.3 1.6 GO:0005602 complement component C1 complex(GO:0005602)
0.0 1.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.3 1.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 1.5 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.5 GO:0042588 zymogen granule(GO:0042588)
0.1 1.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 204 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 3.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 3.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 3.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 3.0 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 2.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 2.4 GO:0051400 BH domain binding(GO:0051400)
0.2 2.3 GO:0031433 telethonin binding(GO:0031433)
0.2 2.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 2.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.7 2.1 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.4 2.1 GO:0004966 galanin receptor activity(GO:0004966)
0.3 2.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 2.0 GO:0017166 vinculin binding(GO:0017166)
0.0 2.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.5 1.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 1.7 GO:0016500 protein-hormone receptor activity(GO:0016500)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.3 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 7.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 6.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 4.6 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 4.0 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 2.4 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.9 PID_MYC_PATHWAY C-MYC pathway
0.0 1.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.5 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 1.5 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.2 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 0.9 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 5.0 REACTOME_TRANSLATION Genes involved in Translation
0.0 3.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 2.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.2 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.2 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 2.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 2.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.6 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis