Motif ID: SREBF1_TFE3

Z-value: 1.346

Transcription factors associated with SREBF1_TFE3:

Gene SymbolEntrez IDGene Name
SREBF1 ENSG00000072310.12 SREBF1
TFE3 ENSG00000068323.12 TFE3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SREBF1hg19_v2_chr17_-_17740325_17740349-0.701.5e-04Click!
TFE3hg19_v2_chrX_-_48901012_48901050-0.341.1e-01Click!


Activity profile for motif SREBF1_TFE3.

activity profile for motif SREBF1_TFE3


Sorted Z-values histogram for motif SREBF1_TFE3

Sorted Z-values for motif SREBF1_TFE3



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1_TFE3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_10764509 9.444 ENST00000591501.1
 ILF3-AS1
ILF3 antisense RNA 1 (head to head)
chr1_-_207119738 6.741 ENST00000356495.4
 PIGR
polymeric immunoglobulin receptor
chr12_+_50355647 6.237 ENST00000293599.6
 AQP5
aquaporin 5
chr22_+_31003133 4.813 ENST00000405742.3
 TCN2
transcobalamin II
chr22_+_31002779 4.708 ENST00000215838.3
 TCN2
transcobalamin II
chr3_-_19988462 4.511 ENST00000344838.4
 EFHB
EF-hand domain family, member B
chr12_-_63328817 4.368 ENST00000228705.6
 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr9_-_138391692 4.106 ENST00000429260.2
 C9orf116
chromosome 9 open reading frame 116
chr2_+_120187465 3.741 ENST00000409826.1
ENST00000417645.1
 TMEM37

transmembrane protein 37

chr1_-_161337662 3.332 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr22_+_31003190 3.257 ENST00000407817.3
 TCN2
transcobalamin II
chr19_+_45504688 3.193 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
 RELB


v-rel avian reticuloendotheliosis viral oncogene homolog B


chr5_-_121413974 3.036 ENST00000231004.4
 LOX
lysyl oxidase
chr16_+_84178874 2.947 ENST00000378553.5
 DNAAF1
dynein, axonemal, assembly factor 1
chr8_-_71581377 2.934 ENST00000276590.4
ENST00000522447.1
 LACTB2

lactamase, beta 2

chr17_+_78075498 2.871 ENST00000302262.3
 GAA
glucosidase, alpha; acid
chr1_+_183605200 2.720 ENST00000304685.4
 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr13_+_43355732 2.706 ENST00000313851.1
 FAM216B
family with sequence similarity 216, member B
chr17_+_78075361 2.683 ENST00000577106.1
ENST00000390015.3
 GAA

glucosidase, alpha; acid

chr13_+_43355683 2.668 ENST00000537894.1
 FAM216B
family with sequence similarity 216, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 398 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 13.6 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
1.3 12.8 GO:0015889 cobalamin transport(GO:0015889)
0.4 8.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.5 6.5 GO:2000111 positive regulation of macrophage apoptotic process(GO:2000111)
1.2 6.2 GO:0015670 carbon dioxide transport(GO:0015670)
1.4 5.6 GO:0002086 diaphragm contraction(GO:0002086)
0.5 5.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 4.5 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.4 4.0 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.2 3.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.4 3.6 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.6 3.4 GO:0038161 prolactin signaling pathway(GO:0038161)
0.8 3.3 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 3.3 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.5 3.1 GO:0015811 L-cystine transport(GO:0015811)
0.3 3.1 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 3.0 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.2 2.9 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 2.7 GO:0046465 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.1 2.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 28.2 GO:0043202 lysosomal lumen(GO:0043202)
0.1 7.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 7.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 7.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 6.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 6.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 5.8 GO:0016607 nuclear speck(GO:0016607)
0.0 4.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 4.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.4 3.9 GO:0036157 outer dynein arm(GO:0036157)
0.0 3.8 GO:0005901 caveola(GO:0005901)
0.5 3.6 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.5 3.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 3.3 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.3 3.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 3.2 GO:0005796 Golgi lumen(GO:0005796)
0.5 3.0 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 3.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.7 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 258 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 12.8 GO:0031419 cobalamin binding(GO:0031419)
0.8 6.7 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.4 6.6 GO:0015250 water channel activity(GO:0015250)
0.3 6.1 GO:0045504 dynein heavy chain binding(GO:0045504)
1.5 6.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.3 5.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.9 5.6 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.2 5.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 5.3 GO:0001047 core promoter binding(GO:0001047)
0.1 4.6 GO:0019003 GDP binding(GO:0019003)
0.4 4.0 GO:0016997 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 3.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 3.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 3.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 3.6 GO:0005516 calmodulin binding(GO:0005516)
0.2 3.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 3.4 GO:0008236 serine-type peptidase activity(GO:0008236)
0.6 3.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.5 3.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.1 3.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 11.1 PID_MYC_PATHWAY C-MYC pathway
0.1 7.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 6.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 5.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 4.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 3.2 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 2.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.7 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 2.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.4 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.1 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 4.8 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 4.1 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 3.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 3.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 3.4 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 3.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 3.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 3.0 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 2.5 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.3 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.1 2.2 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 2.1 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 2.1 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.1 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 2.1 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.0 2.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 1.8 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)