Motif ID: SRF

Z-value: 1.584


Transcription factors associated with SRF:

Gene SymbolEntrez IDGene Name
SRF ENSG00000112658.6 SRF

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRFhg19_v2_chr6_+_43139037_43139094-0.001.0e+00Click!


Activity profile for motif SRF.

activity profile for motif SRF


Sorted Z-values histogram for motif SRF

Sorted Z-values for motif SRF



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF

PNG image of the network

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Top targets:


Showing 1 to 20 of 157 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_151561506 10.036 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_137801160 7.495 ENST00000239938.4
 EGR1
early growth response 1
chr6_+_151561085 7.431 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr11_-_65667997 6.710 ENST00000312562.2
ENST00000534222.1
 FOSL1

FOS-like antigen 1

chr14_-_94443105 5.932 ENST00000555019.1
 ASB2
ankyrin repeat and SOCS box containing 2
chr11_-_65667884 5.729 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
 FOSL1


FOS-like antigen 1


chr14_+_75745477 5.073 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
 FOS




FBJ murine osteosarcoma viral oncogene homolog




chr12_+_4382917 4.787 ENST00000261254.3
 CCND2
cyclin D2
chr19_-_15344243 4.696 ENST00000602233.1
 EPHX3
epoxide hydrolase 3
chr2_-_161056762 4.436 ENST00000428609.2
ENST00000409967.2
 ITGB6

integrin, beta 6

chr2_+_74120094 4.301 ENST00000409731.3
ENST00000345517.3
ENST00000409918.1
ENST00000442912.1
ENST00000409624.1
 ACTG2




actin, gamma 2, smooth muscle, enteric




chr19_+_54372639 4.195 ENST00000391769.2
 MYADM
myeloid-associated differentiation marker
chr19_-_15343773 4.194 ENST00000435261.1
ENST00000594042.1
 EPHX3

epoxide hydrolase 3

chrX_-_153602991 4.171 ENST00000369850.3
ENST00000422373.1
 FLNA

filamin A, alpha

chr2_-_161056802 3.752 ENST00000283249.2
ENST00000409872.1
 ITGB6

integrin, beta 6

chr19_+_16178317 3.723 ENST00000344824.6
ENST00000538887.1
 TPM4

tropomyosin 4

chr10_+_112257596 3.367 ENST00000369583.3
 DUSP5
dual specificity phosphatase 5
chr5_+_150404904 3.154 ENST00000521632.1
 GPX3
glutathione peroxidase 3 (plasma)
chr10_-_90712520 2.998 ENST00000224784.6
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_167599330 2.956 ENST00000367854.3
ENST00000361496.3
 RCSD1

RCSD domain containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 17.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
2.1 12.4 GO:0007296 vitellogenesis(GO:0007296)
1.8 10.9 GO:0090131 mesenchyme migration(GO:0090131)
0.7 8.2 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
2.5 7.5 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.1 5.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.6 5.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 4.8 GO:0071481 cellular response to X-ray(GO:0071481)
0.9 4.4 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.6 4.3 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
1.0 4.2 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.7 4.2 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 4.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 3.5 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 3.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.5 3.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.2 3.0 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 3.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 2.8 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 2.8 GO:0048813 dendrite morphogenesis(GO:0048813)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.0 GO:0005938 cell cortex(GO:0005938)
0.2 17.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 12.4 GO:0042734 presynaptic membrane(GO:0042734)
2.7 8.2 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.7 5.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 5.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.6 5.1 GO:0035976 AP1 complex(GO:0035976)
0.3 5.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 5.0 GO:0031672 A band(GO:0031672)
0.8 4.8 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 4.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 4.3 GO:0031258 lamellipodium membrane(GO:0031258)
1.4 4.2 GO:0031523 Myb complex(GO:0031523)
0.4 3.6 GO:0032982 myosin filament(GO:0032982)
0.0 3.2 GO:0005884 actin filament(GO:0005884)
0.5 3.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 2.9 GO:0055037 recycling endosome(GO:0055037)
0.6 2.8 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 2.8 GO:0043197 dendritic spine(GO:0043197)
0.2 2.6 GO:0097433 dense body(GO:0097433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.0 17.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 8.2 GO:0001618 virus receptor activity(GO:0001618)
1.5 7.5 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 5.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 4.5 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 4.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.0 4.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 3.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 3.2 GO:0008430 selenium binding(GO:0008430)
0.0 3.0 GO:0017022 myosin binding(GO:0017022)
0.3 2.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 2.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 2.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 2.4 GO:0043495 protein anchor(GO:0043495)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.3 GO:0050681 androgen receptor binding(GO:0050681)
0.5 2.2 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 17.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.3 8.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 7.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 5.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 4.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 4.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 4.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 2.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.7 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.5 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 10.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 9.6 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 6.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 5.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 3.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.4 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 2.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.4 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.5 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.9 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 0.6 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors