Motif ID: STAT1_STAT3_BCL6

Z-value: 1.366

Transcription factors associated with STAT1_STAT3_BCL6:

Gene SymbolEntrez IDGene Name
BCL6 ENSG00000113916.13 BCL6
STAT1 ENSG00000115415.14 STAT1
STAT3 ENSG00000168610.10 STAT3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BCL6hg19_v2_chr3_-_187454281_187454357-0.321.3e-01Click!
STAT3hg19_v2_chr17_-_40540377_40540481-0.155.0e-01Click!
STAT1hg19_v2_chr2_-_191878874_1918789760.125.7e-01Click!


Activity profile for motif STAT1_STAT3_BCL6.

activity profile for motif STAT1_STAT3_BCL6


Sorted Z-values histogram for motif STAT1_STAT3_BCL6

Sorted Z-values for motif STAT1_STAT3_BCL6



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT1_STAT3_BCL6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102668879 5.311 ENST00000315274.6
 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr12_+_93964746 3.730 ENST00000536696.2
 SOCS2
suppressor of cytokine signaling 2
chr5_-_146781153 3.726 ENST00000520473.1
 DPYSL3
dihydropyrimidinase-like 3
chr7_+_134464414 3.658 ENST00000361901.2
 CALD1
caldesmon 1
chr5_-_140013275 3.627 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
 CD14


CD14 molecule


chr7_+_134464376 3.563 ENST00000454108.1
ENST00000361675.2
 CALD1

caldesmon 1

chr17_+_2699697 3.498 ENST00000254695.8
ENST00000366401.4
ENST00000542807.1
 RAP1GAP2


RAP1 GTPase activating protein 2


chr20_-_43280361 3.180 ENST00000372874.4
 ADA
adenosine deaminase
chr1_-_153521597 3.135 ENST00000368712.1
 S100A3
S100 calcium binding protein A3
chr17_+_6347729 3.100 ENST00000572447.1
 FAM64A
family with sequence similarity 64, member A
chr17_+_6347761 3.035 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
 FAM64A




family with sequence similarity 64, member A




chr17_-_76356148 3.031 ENST00000587578.1
ENST00000330871.2
 SOCS3

suppressor of cytokine signaling 3

chrX_-_48328551 2.875 ENST00000376876.3
 SLC38A5
solute carrier family 38, member 5
chrX_-_48328631 2.857 ENST00000429543.1
ENST00000317669.5
 SLC38A5

solute carrier family 38, member 5

chr3_+_50649302 2.744 ENST00000446044.1
 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr19_+_10381769 2.697 ENST00000423829.2
ENST00000588645.1
 ICAM1

intercellular adhesion molecule 1

chr8_-_91095099 2.665 ENST00000265431.3
 CALB1
calbindin 1, 28kDa
chr5_-_39274617 2.564 ENST00000510188.1
 FYB
FYN binding protein
chr12_+_53443963 2.471 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
 TENC1


tensin like C1 domain containing phosphatase (tensin 2)


chr1_-_153521714 2.468 ENST00000368713.3
 S100A3
S100 calcium binding protein A3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 258 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.7 GO:0015816 glycine transport(GO:0015816)
0.0 5.1 GO:0006936 muscle contraction(GO:0006936)
0.1 4.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.8 3.9 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.2 3.7 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.9 3.6 GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.2 3.6 GO:0051764 actin crosslink formation(GO:0051764)
0.1 3.6 GO:0007520 myoblast fusion(GO:0007520)
0.1 3.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
1.1 3.2 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.1 3.2 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.8 3.0 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.3 2.8 GO:0072144 glomerular mesangial cell development(GO:0072144)
0.7 2.7 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.3 2.7 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.2 2.7 GO:0044351 macropinocytosis(GO:0044351)
0.0 2.7 GO:0008361 regulation of cell size(GO:0008361)
0.4 2.5 GO:0051639 actin filament network formation(GO:0051639)
0.2 2.5 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.2 2.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.5 7.1 GO:0030478 actin cap(GO:0030478)
0.0 6.3 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 3.9 GO:0005884 actin filament(GO:0005884)
0.7 3.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 3.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 3.1 GO:0031941 filamentous actin(GO:0031941)
0.1 3.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 2.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 2.7 GO:0043195 terminal bouton(GO:0043195)
0.0 2.6 GO:0001772 immunological synapse(GO:0001772)
0.7 2.1 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.9 GO:0097443 sorting endosome(GO:0097443)
0.6 1.8 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.6 1.8 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.3 1.8 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 1.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.7 GO:0005614 interstitial matrix(GO:0005614)
0.4 1.6 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 1.6 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.3 GO:0005523 tropomyosin binding(GO:0005523)
0.1 7.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 5.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.8 4.1 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.4 3.9 GO:0051525 NFAT protein binding(GO:0051525)
0.1 3.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.6 3.7 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.3 3.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 3.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 3.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.5 2.7 GO:0005499 vitamin D binding(GO:0005499)
0.1 2.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 2.7 GO:0001618 virus receptor activity(GO:0001618)
0.0 2.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.6 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 2.4 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 2.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 2.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 2.3 GO:0005184 neuropeptide hormone activity(GO:0005184)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 6.8 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 6.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 4.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 4.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 3.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 2.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 2.3 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 2.1 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.2 1.9 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.1 1.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 7.6 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.3 7.4 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.2 7.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 6.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 5.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 4.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 4.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 3.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 3.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.8 REACTOME_KINESINS Genes involved in Kinesins
0.1 2.6 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 2.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 2.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 2.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.8 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.8 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.7 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis