Motif ID: STAT5A

Z-value: 0.851


Transcription factors associated with STAT5A:

Gene SymbolEntrez IDGene Name
STAT5A ENSG00000126561.12 STAT5A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT5Ahg19_v2_chr17_+_40440481_404405610.735.4e-05Click!


Activity profile for motif STAT5A.

activity profile for motif STAT5A


Sorted Z-values histogram for motif STAT5A

Sorted Z-values for motif STAT5A



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5A

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_142829162 7.266 ENST00000291009.3
 PIP
prolactin-induced protein
chr9_-_34397800 3.796 ENST00000297623.2
 C9orf24
chromosome 9 open reading frame 24
chr19_-_55672037 3.072 ENST00000588076.1
 DNAAF3
dynein, axonemal, assembly factor 3
chr17_+_9479944 2.454 ENST00000396219.3
ENST00000352665.5
 WDR16

WD repeat domain 16

chr6_+_32407619 2.380 ENST00000395388.2
ENST00000374982.5
 HLA-DRA

major histocompatibility complex, class II, DR alpha

chr11_+_73358594 2.309 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
 PLEKHB1


pleckstrin homology domain containing, family B (evectins) member 1


chr7_+_105603683 2.140 ENST00000317716.9
 CDHR3
cadherin-related family member 3
chr1_+_47264711 2.128 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr3_-_148939835 2.126 ENST00000264613.6
 CP
ceruloplasmin (ferroxidase)
chr9_+_124922171 2.114 ENST00000373764.3
ENST00000536616.1
 MORN5

MORN repeat containing 5

chr16_+_19421803 2.053 ENST00000541464.1
 TMC5
transmembrane channel-like 5
chr12_-_15082050 1.947 ENST00000540097.1
 ERP27
endoplasmic reticulum protein 27
chr14_+_96949319 1.853 ENST00000554706.1
 AK7
adenylate kinase 7
chr14_-_21270561 1.825 ENST00000412779.2
 RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr11_+_27062860 1.797 ENST00000528583.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr21_-_35883613 1.782 ENST00000337385.3
 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr11_+_111385497 1.679 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
 C11orf88


chromosome 11 open reading frame 88


chr15_-_56757329 1.657 ENST00000260453.3
 MNS1
meiosis-specific nuclear structural 1
chr1_+_78956651 1.645 ENST00000370757.3
ENST00000370756.3
 PTGFR

prostaglandin F receptor (FP)

chr2_-_28113217 1.637 ENST00000444339.2
 RBKS
ribokinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 268 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 6.9 GO:0044458 motile cilium assembly(GO:0044458)
0.0 5.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 3.1 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 3.1 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.2 2.9 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315) negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 2.9 GO:0060271 cilium morphogenesis(GO:0060271)
0.4 2.8 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 2.5 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.6 2.4 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.2 2.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 2.4 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.3 2.3 GO:0071461 cellular response to redox state(GO:0071461)
0.2 2.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 2.3 GO:0006825 copper ion transport(GO:0006825)
0.5 2.2 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.4 2.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.3 2.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 2.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 2.0 GO:0070986 left/right axis specification(GO:0070986)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 3.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 3.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.6 2.4 GO:0097224 sperm connecting piece(GO:0097224)
0.0 2.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.2 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 2.2 GO:0072562 blood microparticle(GO:0072562)
0.0 2.1 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.7 GO:0097418 neurofibrillary tangle(GO:0097418)
0.3 1.6 GO:0005879 axonemal microtubule(GO:0005879)
0.1 1.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 1.5 GO:0000145 exocyst(GO:0000145)
0.0 1.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.2 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.2 GO:0036038 MKS complex(GO:0036038)
0.0 1.2 GO:0097546 ciliary base(GO:0097546)
0.0 1.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.4 1.1 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 1.1 GO:0005579 membrane attack complex(GO:0005579)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.1 GO:0019864 IgG binding(GO:0019864)
0.4 5.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 3.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.8 3.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 3.1 GO:0019003 GDP binding(GO:0019003)
0.1 2.9 GO:0070330 aromatase activity(GO:0070330)
0.0 2.9 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.2 2.7 GO:0031433 telethonin binding(GO:0031433)
0.3 2.4 GO:0004522 ribonuclease A activity(GO:0004522)
0.2 2.4 GO:0032027 myosin light chain binding(GO:0032027)
0.6 2.3 GO:1904493 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)
0.2 2.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 2.2 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 2.0 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.3 1.9 GO:0004127 cytidylate kinase activity(GO:0004127)
0.2 1.9 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.7 GO:0051787 misfolded protein binding(GO:0051787)
0.5 1.6 GO:0004958 prostaglandin F receptor activity(GO:0004958)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.1 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.0 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.4 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 2.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 2.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 2.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.9 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 1.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.6 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 1.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.1 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.1 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.1 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.1 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 1.0 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.0 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins