Motif ID: STAT5B
Z-value: 1.118
Transcription factors associated with STAT5B:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| STAT5B | ENSG00000173757.5 | STAT5B |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT5B | hg19_v2_chr17_-_40428359_40428462 | -0.25 | 2.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process(GO:0042351) |
| 0.4 | 1.3 | GO:0090283 | regulation of protein glycosylation in Golgi(GO:0090283) |
| 0.4 | 4.6 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.2 | 0.6 | GO:1902824 | positive regulation of late endosome to lysosome transport(GO:1902824) |
| 0.2 | 0.6 | GO:0071418 | cellular response to amine stimulus(GO:0071418) |
| 0.2 | 5.2 | GO:0070233 | negative regulation of T cell apoptotic process(GO:0070233) |
| 0.2 | 0.7 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) |
| 0.2 | 0.5 | GO:0035552 | oxidative single-stranded DNA demethylation(GO:0035552) |
| 0.2 | 3.3 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.2 | 0.9 | GO:0032185 | regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185) glomerular visceral epithelial cell migration(GO:0090521) |
| 0.1 | 1.0 | GO:0042126 | nitrate metabolic process(GO:0042126) |
| 0.1 | 0.4 | GO:2000502 | negative regulation of natural killer cell chemotaxis(GO:2000502) |
| 0.1 | 2.3 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.1 | 1.0 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.1 | 0.4 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
| 0.1 | 1.0 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.1 | 1.3 | GO:0015747 | urate transport(GO:0015747) |
| 0.1 | 0.9 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.1 | 1.7 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.1 | 0.2 | GO:0003032 | detection of oxygen(GO:0003032) |
| 0.1 | 0.5 | GO:2000259 | positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) |
| 0.1 | 0.7 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.1 | 2.6 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 0.4 | GO:0002943 | tRNA dihydrouridine synthesis(GO:0002943) |
| 0.1 | 0.4 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.1 | 0.7 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 0.2 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.0 | 0.6 | GO:0032782 | bile acid secretion(GO:0032782) |
| 0.0 | 0.8 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.0 | 0.2 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.0 | 0.8 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 0.0 | 1.4 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.3 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) ribosomal small subunit export from nucleus(GO:0000056) |
| 0.0 | 0.3 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.0 | 0.2 | GO:0002035 | brain renin-angiotensin system(GO:0002035) angiotensin-mediated drinking behavior(GO:0003051) operant conditioning(GO:0035106) positive regulation of saliva secretion(GO:0046878) |
| 0.0 | 0.2 | GO:0032380 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 0.0 | 0.1 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.0 | 0.4 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.0 | 0.1 | GO:0019566 | arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373) |
| 0.0 | 0.3 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.0 | 0.2 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.0 | 0.3 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.0 | 0.1 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.0 | 3.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.4 | GO:0002031 | G-protein coupled receptor internalization(GO:0002031) |
| 0.0 | 0.7 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 2.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.1 | GO:0042938 | dipeptide transport(GO:0042938) |
| 0.0 | 1.0 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 0.2 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 0.8 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.2 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 0.2 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.0 | 0.1 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.0 | 0.2 | GO:0015781 | pyrimidine nucleotide-sugar transport(GO:0015781) |
| 0.0 | 0.4 | GO:0045638 | negative regulation of myeloid cell differentiation(GO:0045638) |
| 0.0 | 0.3 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) |
| 0.0 | 1.2 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.0 | 0.1 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 0.4 | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway(GO:0060071) |
| 0.0 | 0.7 | GO:0032479 | regulation of type I interferon production(GO:0032479) |
| 0.0 | 0.1 | GO:0019075 | virus maturation(GO:0019075) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.3 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.2 | 1.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.1 | 0.4 | GO:0000438 | core TFIIH complex portion of holo TFIIH complex(GO:0000438) |
| 0.1 | 0.7 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 0.3 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 0.2 | GO:0009330 | DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330) |
| 0.1 | 0.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 0.4 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 3.7 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 0.1 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 0.0 | 0.3 | GO:0000923 | equatorial microtubule organizing center(GO:0000923) |
| 0.0 | 0.9 | GO:0044447 | axoneme part(GO:0044447) |
| 0.0 | 0.7 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 2.3 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.0 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.5 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.8 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 1.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.6 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 1.1 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 1.7 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 0.4 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 1.0 | GO:0015030 | Cajal body(GO:0015030) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.6 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 1.1 | 3.3 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 0.5 | 7.8 | GO:0019864 | IgG binding(GO:0019864) |
| 0.4 | 2.6 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.2 | 0.6 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.2 | 0.6 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.2 | 1.0 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 0.2 | 0.7 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.2 | 0.5 | GO:0035514 | DNA demethylase activity(GO:0035514) |
| 0.1 | 0.7 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.1 | 1.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.8 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.1 | 0.4 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.1 | 1.3 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 0.5 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.1 | 0.2 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 0.1 | 0.8 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.1 | 0.2 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.1 | 0.4 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.0 | 0.3 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 0.0 | 3.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 0.7 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 1.2 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.2 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.0 | 0.4 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.0 | 0.8 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 0.1 | GO:0046556 | alpha-L-arabinofuranosidase activity(GO:0046556) |
| 0.0 | 0.9 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 0.2 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.0 | 0.3 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 1.7 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.3 | GO:0005402 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) |
| 0.0 | 0.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.2 | GO:0016174 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 2.2 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.0 | 0.1 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.0 | 0.2 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.0 | 0.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 2.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.4 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 20.6 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.1 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 0.9 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 2.6 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 1.0 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 3.6 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 20.6 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 1.0 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 1.5 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.3 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 4.6 | REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 1.2 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 0.4 | REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.3 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.4 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.5 | REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.0 | 0.6 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.2 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
