Motif ID: STAT5B

Z-value: 1.118


Transcription factors associated with STAT5B:

Gene SymbolEntrez IDGene Name
STAT5B ENSG00000173757.5 STAT5B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT5Bhg19_v2_chr17_-_40428359_40428462-0.252.5e-01Click!


Activity profile for motif STAT5B.

activity profile for motif STAT5B


Sorted Z-values histogram for motif STAT5B

Sorted Z-values for motif STAT5B



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5B

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_142829162 6.674 ENST00000291009.3
 PIP
prolactin-induced protein
chr19_-_44860820 3.495 ENST00000354340.4
ENST00000337401.4
ENST00000587909.1
 ZNF112


zinc finger protein 112


chr19_+_35168567 2.958 ENST00000457781.2
ENST00000505163.1
ENST00000505242.1
ENST00000423823.2
ENST00000507959.1
ENST00000446502.2
 ZNF302





zinc finger protein 302





chr19_+_44669280 2.774 ENST00000590089.1
ENST00000454662.2
 ZNF226

zinc finger protein 226

chr18_-_24765248 2.618 ENST00000580774.1
ENST00000284224.8
 CHST9

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9

chr19_+_35168633 2.510 ENST00000505365.2
 ZNF302
zinc finger protein 302
chr11_+_27062860 2.353 ENST00000528583.1
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr11_+_27062502 2.296 ENST00000263182.3
 BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chrY_+_2709906 1.862 ENST00000430575.1
 RPS4Y1
ribosomal protein S4, Y-linked 1
chrY_+_2709527 1.859 ENST00000250784.8
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr5_+_140248518 1.794 ENST00000398640.2
 PCDHA11
protocadherin alpha 11
chr19_+_44645700 1.776 ENST00000592437.1
 ZNF234
zinc finger protein 234
chrX_-_154250989 1.740 ENST00000360256.4
 F8
coagulation factor VIII, procoagulant component
chr19_+_54024251 1.719 ENST00000253144.9
 ZNF331
zinc finger protein 331
chr16_-_53737722 1.655 ENST00000569716.1
ENST00000562588.1
ENST00000562230.1
ENST00000379925.3
ENST00000563746.1
ENST00000568653.3
 RPGRIP1L





RPGRIP1-like





chr16_-_53737795 1.646 ENST00000262135.4
ENST00000564374.1
ENST00000566096.1
 RPGRIP1L


RPGRIP1-like


chr5_+_178450753 1.644 ENST00000444149.2
ENST00000519896.1
ENST00000522442.1
 ZNF879


zinc finger protein 879


chr18_-_53253323 1.460 ENST00000540999.1
ENST00000563888.2
 TCF4

transcription factor 4

chr3_+_130745769 1.427 ENST00000412440.2
 NEK11
NIMA-related kinase 11
chr19_+_58281014 1.377 ENST00000391702.3
ENST00000598885.1
ENST00000598183.1
ENST00000396154.2
ENST00000599802.1
ENST00000396150.4
 ZNF586





zinc finger protein 586






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.4 4.6 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 3.7 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 3.3 GO:0021670 lateral ventricle development(GO:0021670)
0.1 2.6 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 2.3 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 2.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.7 2.2 GO:0042351 'de novo' GDP-L-fucose biosynthetic process(GO:0042351)
0.1 1.7 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 1.4 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.4 1.3 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.1 1.3 GO:0015747 urate transport(GO:0015747)
0.0 1.2 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.1 1.0 GO:0042126 nitrate metabolic process(GO:0042126)
0.1 1.0 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 1.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 1.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.2 0.9 GO:0032185 regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185) glomerular visceral epithelial cell migration(GO:0090521)
0.1 0.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.8 GO:0001973 adenosine receptor signaling pathway(GO:0001973)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0005844 polysome(GO:0005844)
0.7 3.3 GO:0005879 axonemal microtubule(GO:0005879)
0.0 2.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.2 1.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 1.1 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 1.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.0 GO:0015030 Cajal body(GO:0015030)
0.0 0.9 GO:0044447 axoneme part(GO:0044447)
0.0 0.8 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.5 GO:0030914 STAGA complex(GO:0030914)
0.1 0.4 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.1 0.4 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.6 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.5 7.8 GO:0019864 IgG binding(GO:0019864)
1.2 4.6 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 3.7 GO:0019843 rRNA binding(GO:0019843)
1.1 3.3 GO:0031862 prostanoid receptor binding(GO:0031862)
0.4 2.6 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 2.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.2 GO:0009055 electron carrier activity(GO:0009055)
0.0 1.7 GO:0005507 copper ion binding(GO:0005507)
0.1 1.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 1.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 1.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.9 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.8 GO:0050733 RS domain binding(GO:0050733)
0.1 0.8 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.8 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 0.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 0.7 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.7 GO:0004887 thyroid hormone receptor activity(GO:0004887)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.6 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.0 4.6 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 3.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.6 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.2 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.0 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 0.9 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.4 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.4 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)